ID   CAF20_VANPO             Reviewed;         152 AA.
AC   A7TRH1;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=Cap-associated protein CAF20;
GN   Name=CAF20; ORFNames=Kpol_413p6;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Acts as an inhibitor of cap-dependent translation. Competes
CC       with eIF4G1 and EAP1 for binding to eIF4E and interferes with the
CC       formation of the eIF4F complex, inhibiting translation and stabilizing
CC       mRNA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CAF20 family. {ECO:0000305}.
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DR   EMBL; DS480479; EDO15131.1; -; Genomic_DNA.
DR   RefSeq; XP_001642989.1; XM_001642939.1.
DR   AlphaFoldDB; A7TRH1; -.
DR   SMR; A7TRH1; -.
DR   STRING; 436907.A7TRH1; -.
DR   EnsemblFungi; EDO15131; EDO15131; Kpol_413p6.
DR   GeneID; 5543191; -.
DR   KEGG; vpo:Kpol_413p6; -.
DR   eggNOG; ENOG502S2E7; Eukaryota.
DR   HOGENOM; CLU_128343_0_0_1; -.
DR   InParanoid; A7TRH1; -.
DR   OMA; GHFNRRR; -.
DR   OrthoDB; 1474950at2759; -.
DR   PhylomeDB; A7TRH1; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005845; C:mRNA cap binding complex; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0017148; P:negative regulation of translation; IEA:UniProtKB-KW.
DR   InterPro; IPR031456; Caf20.
DR   Pfam; PF17052; CAF20; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Phosphoprotein; Protein biosynthesis;
KW   Protein synthesis inhibitor; Reference proteome; Translation regulation.
FT   CHAIN           1..152
FT                   /note="Cap-associated protein CAF20"
FT                   /id="PRO_0000330091"
FT   REGION          46..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        52..69
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   152 AA;  17304 MW;  2B453B2CC71A660E CRC64;
     MVRYTVDELF HLKPTESLPV QFDAEEFKAI IEKVKQIQAL KEEEFNAHGG HFNRRRSSHH
     HHGRPKVKHT KPKVTTDSDG WSTFEAANKK VNEDEESENV SVAVVPETLK VKPNNKNISS
     SRPADNKDII ADKQTHSFNA FAALESDEEE ET