ID   UVRC_STRMU              Reviewed;         595 AA.
AC   Q8CWX4;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=SMU_1241;
OS   Streptococcus mutans serotype c (strain ATCC 700610 / UA159).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=210007;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700610 / UA159;
RX   PubMed=12397186; DOI=10.1073/pnas.172501299;
RA   Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B.,
RA   Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S.,
RA   Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J.;
RT   "Genome sequence of Streptococcus mutans UA159, a cariogenic dental
RT   pathogen.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; AE014133; AAN58926.1; -; Genomic_DNA.
DR   RefSeq; NP_721620.1; NC_004350.2.
DR   RefSeq; WP_002263201.1; NC_004350.2.
DR   AlphaFoldDB; Q8CWX4; -.
DR   SMR; Q8CWX4; -.
DR   STRING; 210007.SMU_1241; -.
DR   PRIDE; Q8CWX4; -.
DR   EnsemblBacteria; AAN58926; AAN58926; SMU_1241.
DR   GeneID; 66817372; -.
DR   KEGG; smu:SMU_1241; -.
DR   PATRIC; fig|210007.7.peg.1113; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_9; -.
DR   OMA; HIECFDN; -.
DR   PhylomeDB; Q8CWX4; -.
DR   Proteomes; UP000002512; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..595
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000264957"
FT   DOMAIN          14..91
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          196..231
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   595 AA;  68892 MW;  FFC128B30BE52428 CRC64;
     MNELIKHKLE LLPDSPGCYI HKDKNGTIIY VGKAKNLKNR VRSYFHGSHN TKTELLVSEI
     EDFEYIVTGS NTEALLLEIN LIQENKPKYN IRLKDDKSYP FIKITNEPYP RLLITRQVKK
     DGGLYFGPYP DSGAATEIKR LLDRLFPFKK CTNPANKVCF YYHLGQCKAH TICQTDQTYW
     DSLKEDVKNF LNGRDDKIVN ELRDKMTKAS ELMEFERAAE YRDLIEGIGL LRTKQRVMNQ
     DMQDRDIFGY YVDKGWMCVQ VFFIRQGKLI QRDVNMFPYY NESEEDFLTY VGQFYQDNRH
     FIPKEIFIPR NIDETLVKAV VNTKIIKPQR GEKKQLVNLA TKNARVSLQQ KFDLLEKDIR
     KTHGAIENIG DLLNIPKPVR IEAFDNSNIQ GTSPVAAMVV FVDGKPSKKD YRKFKIKTVI
     GPDDYASMRE VIYRRYSRVM RDGLTPPDLI IIDGGQGQVN VARDVIENKL GLDIPIAGLQ
     KNDKHQTHEL LFGDPLEVIP LPRNSEEFFL LQRIQDEVHR FAITFHRQLR GKNTFSSKLN
     GIAGLGPKRK QLLMKHFKNL PNIQKASLDD IINCGIPKNV AENIQESLRE EREKG