ID   UVRC_STRPN              Reviewed;         614 AA.
AC   Q97S07;
DT   19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=SP_0618;
OS   Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=170187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-334 / TIGR4;
RX   PubMed=11463916; DOI=10.1126/science.1061217;
RA   Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA   Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA   Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA   Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA   McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA   Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA   Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT   "Complete genome sequence of a virulent isolate of Streptococcus
RT   pneumoniae.";
RL   Science 293:498-506(2001).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; AE005672; AAK74770.1; -; Genomic_DNA.
DR   PIR; A95072; A95072.
DR   RefSeq; WP_001061130.1; NZ_AKVY01000001.1.
DR   AlphaFoldDB; Q97S07; -.
DR   SMR; Q97S07; -.
DR   STRING; 170187.SP_0618; -.
DR   EnsemblBacteria; AAK74770; AAK74770; SP_0618.
DR   KEGG; spn:SP_0618; -.
DR   eggNOG; COG0322; Bacteria.
DR   OMA; HIECFDN; -.
DR   PhylomeDB; Q97S07; -.
DR   BioCyc; SPNE170187:G1FZB-634-MON; -.
DR   Proteomes; UP000000585; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..614
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000138346"
FT   DOMAIN          14..91
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          196..231
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   REGION          595..614
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   614 AA;  70409 MW;  E2EACE1B256D5B76 CRC64;
     MNNLIKSKLE LLPTSPGCYI HKDKNGTIIY VGKAKNLRNR VRSYFRGSHD TKTEALVSEI
     VDFEFIVTES NIEALLLEIN LIKENKPKYN IMLKDDKSYP FIKITNERYP RLIITRQVKK
     DGGLYFGPYP DVGAANEIKR LLDRIFPFRK CTNPPSKVCF YYHIGQCMAH TICKKDEAYF
     KSMAQEVSDF LKGQDDKIID DLKSKMAVAA QSMEFERAAE YRDLIQAIGT LRTKQRVMAK
     DLQNRDVFGY YVDKGWMCVQ VFFVRQGKLI ERDVNLFPYF NDPDEDFLTY VGQFYQEKSH
     LVPNEVLIPQ DIDEEAVKAL VDSKILKPQR GEKKQLVNLA IKNARVSLEQ KFNLLEKSVE
     KTQGAIENLG RLLQIPTPVR IESFDNSNIM GTSPVSAMVV FVNGKPSKKD YRKYKIKTVV
     GPDDYASMRE VIRRRYGRVQ REALTPPDLI VIDGGQGQVN IAKQVIQEEL GLDIPIAGLQ
     KNDKHQTHEL LFGDPLEVVD LSRNSQEFFL LQRIQDEVHR FAITFHRQLR SKNSFSSQLD
     GIDGLGPKRK QNLMKHFKSL TKIKEASVDE IVEVGVPRVV AEAVQRKLNP QGEALPQVAE
     ERVDYQTEGN HNEP