ID   UVRC_STRSV              Reviewed;         611 AA.
AC   A3CNE1;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=SSA_1297;
OS   Streptococcus sanguinis (strain SK36).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=388919;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SK36;
RX   PubMed=17277061; DOI=10.1128/jb.01808-06;
RA   Xu P., Alves J.M., Kitten T., Brown A., Chen Z., Ozaki L.S., Manque P.,
RA   Ge X., Serrano M.G., Puiu D., Hendricks S., Wang Y., Chaplin M.D., Akan D.,
RA   Paik S., Peterson D.L., Macrina F.L., Buck G.A.;
RT   "Genome of the opportunistic pathogen Streptococcus sanguinis.";
RL   J. Bacteriol. 189:3166-3175(2007).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000387; ABN44696.1; -; Genomic_DNA.
DR   RefSeq; WP_011837033.1; NC_009009.1.
DR   RefSeq; YP_001035246.1; NC_009009.1.
DR   AlphaFoldDB; A3CNE1; -.
DR   SMR; A3CNE1; -.
DR   STRING; 388919.SSA_1297; -.
DR   EnsemblBacteria; ABN44696; ABN44696; SSA_1297.
DR   KEGG; ssa:SSA_1297; -.
DR   PATRIC; fig|388919.9.peg.1234; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_9; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   Proteomes; UP000002148; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..611
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_1000077853"
FT   DOMAIN          14..91
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          196..231
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   REGION          587..611
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   611 AA;  70135 MW;  0CFA61DBF7073E9D CRC64;
     MNKLIQSKLE LLPTSPGCYI HKDKNDTIIY VGKAKNLRNR VRSYFRGSHD TKTEALVSEI
     EDFEFIVTES NIEALLLEIN LIKENQPKYN IMLKDDKSYP FIKITNETYP RLIITRQVKK
     DVGLYFGPYP DVGAANEIKR LLDRLFPFRK CTNPPEKVCF YYHLGQCKAH TICKVDSQYF
     KELAQEVAAF LKGQDDQIIE DLRGKMAGAA QAMEFEKAAE YRDLIQSIGT LRTKQRVMAK
     DLQNRDVFGY YVDKGWMCVQ VFFVRQGKLI ERDVNLFPYY NDPDEDFLTY IGQFYQEKSH
     LKPNEILIPA DIDEEAVRAM VDTKVLKPQR GEKKQLVNLA IKNARVSLQQ KFDLLEKSIE
     KTQGAIENLG QLLNIPTPVR IESFDNSNIM GTSPVSAMVV FVNGKPSKKD YRKYKIKTVV
     GPDDYASMRE VIKRRYSRVI RDGLTPPDLI VIDGGQGQVN IAKEVIQEQL GLDIPIAGLQ
     KNDKHQTHEL LFGDPLQVVE LSRNSQEFFL LQRIQDEVHR FAITFHRQLR SKNSFSSQLD
     GIEGLGPKRK QNLMKHFKSL TKIKEASVDQ IVEVGVPRAV AEAVREKLNP KTQEQEQAQL
     REVAEPQIGL E