UVRC_SYNJB
ID UVRC_SYNJB Reviewed; 623 AA.
AC Q2JM21;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=CYB_1251;
OS Synechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium
OS Yellowstone B-Prime).
OC Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus;
OC unclassified Synechococcus.
OX NCBI_TaxID=321332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JA-2-3B'a(2-13);
RX PubMed=18059494; DOI=10.1038/ismej.2007.46;
RA Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N.,
RA Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F.;
RT "Population level functional diversity in a microbial community revealed by
RT comparative genomic and metagenomic analyses.";
RL ISME J. 1:703-713(2007).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC lesion. The N-terminal half is responsible for the 3' incision and the
CC C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC Rule:MF_00203}.
CC -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC {ECO:0000255|HAMAP-Rule:MF_00203}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC Rule:MF_00203}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000240; ABD02226.1; -; Genomic_DNA.
DR RefSeq; WP_011432878.1; NC_007776.1.
DR AlphaFoldDB; Q2JM21; -.
DR SMR; Q2JM21; -.
DR STRING; 321332.CYB_1251; -.
DR KEGG; cyb:CYB_1251; -.
DR eggNOG; COG0322; Bacteria.
DR HOGENOM; CLU_014841_3_2_3; -.
DR OMA; HIECFDN; -.
DR OrthoDB; 1036075at2; -.
DR Proteomes; UP000001938; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.420.340; -; 1.
DR Gene3D; 3.40.1440.10; -; 1.
DR HAMAP; MF_00203; UvrC; 1.
DR InterPro; IPR041663; DisA/LigA_HHH.
DR InterPro; IPR000305; GIY-YIG_endonuc.
DR InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR001943; UVR_dom.
DR InterPro; IPR036876; UVR_dom_sf.
DR InterPro; IPR004791; UvrC.
DR InterPro; IPR001162; UvrC_RNase_H_dom.
DR InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR Pfam; PF01541; GIY-YIG; 1.
DR Pfam; PF12826; HHH_2; 1.
DR Pfam; PF02151; UVR; 1.
DR Pfam; PF08459; UvrC_HhH_N; 1.
DR SMART; SM00465; GIYc; 1.
DR SMART; SM00278; HhH1; 2.
DR SUPFAM; SSF46600; SSF46600; 1.
DR SUPFAM; SSF47781; SSF47781; 1.
DR SUPFAM; SSF82771; SSF82771; 1.
DR TIGRFAMs; TIGR00194; uvrC; 1.
DR PROSITE; PS50164; GIY_YIG; 1.
DR PROSITE; PS50151; UVR; 1.
DR PROSITE; PS50165; UVRC; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW Reference proteome; SOS response.
FT CHAIN 1..623
FT /note="UvrABC system protein C"
FT /id="PRO_0000264965"
FT DOMAIN 21..100
FT /note="GIY-YIG"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT DOMAIN 210..245
FT /note="UVR"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ SEQUENCE 623 AA; 71459 MW; C6C39EAE5527494B CRC64;
MTVPLIHSRD VLESRLKEIP AEPGVYLMRD ATDQILYVGK SKKLRSRVRS YFRFTSDLSP
RIQRMVAQVC EIEFIVTDNE SEALALEDNL IKTHQPPYNV LLKDDKKYPY LCITWSEPYP
QLYITRHRRL DRNQDKYYGP YTDVGLLRHT LGLVKRIFPL RQRPKPLYKD RTCLNYDIGR
CPGVCQGLIS PEEYRKTLTQ VAMIFQGQTD ELIRELQEKM IQAAEQENYE AAARYRDQIR
GLEQLGESQK VSLPNSTVSR DALALAMNDS RACIQLFQVR AGKLVGRLGF VAENRGDDPG
LILQRALQEH YQYCDPVEIP SEILTQYELP DHDFLESWLS QKKGRKVSLV APQRQSKAEL
IELVERNAQL ELTRTQRLAD RDAAALERLA EVLDLPDVPR RLEAYDISHI QGSDAVASQV
VFIDGLPAKQ HYRRYKIRNP EVRPGHSDDF ASHAEVARRR FSKMTPEDQP DLVLIDGGKG
QLSAVMAVLA DLGLDHLPVI ALAKREEEIF LPGNPVPLRL PAQDPARLLL QRLRDEAHRF
ALAFHRQQRK ARQHASTLDE IPGLGKYRQK LLMEEFRSIA RIQVASEDQL AQVPGIGPKI
ARQIYRYFHP ETQAESPETA QVE