ID   UVRC_SYNP6              Reviewed;         643 AA.
AC   Q5N031;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=syc2149_d;
OS   Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis
OS   nidulans).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus.
OX   NCBI_TaxID=269084;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27144 / PCC 6301 / SAUG 1402/1;
RX   PubMed=17211581; DOI=10.1007/s11120-006-9122-4;
RA   Sugita C., Ogata K., Shikata M., Jikuya H., Takano J., Furumichi M.,
RA   Kanehisa M., Omata T., Sugiura M., Sugita M.;
RT   "Complete nucleotide sequence of the freshwater unicellular cyanobacterium
RT   Synechococcus elongatus PCC 6301 chromosome: gene content and
RT   organization.";
RL   Photosyn. Res. 93:55-67(2007).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; AP008231; BAD80339.1; -; Genomic_DNA.
DR   RefSeq; WP_011244459.1; NC_006576.1.
DR   AlphaFoldDB; Q5N031; -.
DR   SMR; Q5N031; -.
DR   STRING; 269084.syc2149_d; -.
DR   EnsemblBacteria; BAD80339; BAD80339; syc2149_d.
DR   KEGG; syc:syc2149_d; -.
DR   eggNOG; COG0322; Bacteria.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000001175; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR041663; DisA/LigA_HHH.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF12826; HHH_2; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..643
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000227484"
FT   DOMAIN          25..104
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          214..249
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   643 AA;  73659 MW;  2A0F33B785790985 CRC64;
     MIAATPMPLL KQPDRLEARL RELPAEPGVY FMRDASDRIL YIGKSKKLRS RVRSYFRDLE
     RLNPRINLMV RQVCEIEIIV TDTEAEALAL EANLIKQHQP HFNVLLKDDK KYPYLCITWS
     DDYPRIFITR KRRLGNSRDR YYGPYVDTRL LRHTLFLVKR LFPLRQRPQP LFKDRTCLNY
     DIGRCPGVCQ SLIRPDDYRK TLQKVAMIFQ GRSSELVELL EAQMLQAAEN LEFEKAAKIR
     DQIRGLEGLG AEQKVQLPDD RISRDAIALA MDEQHACIQL FQIRAGKLVG RLGFVADAQS
     GSAAAIAQRV LEEHYASVDS VEIPQEVLVQ HDLPEAELLE VWLSERRGRK VEILSPQRQI
     KADLIAMVER NAEYELARTQ QSAERHTASL IDLADLLDLP ELPRRIEGYD ISHIQGSDAV
     ASQVVFIDGL PAKQHYRRYK IRNPEVRAGH SDDFASLAEV LHRRFRKFAE AKARGESLAP
     SEQRQGSLLR PDDLADFPDL VMIDGGKGQL SAVVEVLRNL NLLEDVKLCS LAKKREEIFL
     PGASDPLPTD AEQPGVQLLR RLRDEAHRFA VSFHRQKRTE RMRRSRLDDI PGLGHKRQKE
     LLAHFRSIDY LRLATPEQIA EVPGIGAVLA QQIWGYFHPS ETA