ID   UVRC_SYNS9              Reviewed;         661 AA.
AC   Q3AXU8;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 2.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203};
GN   OrderedLocusNames=Syncc9902_1115;
OS   Synechococcus sp. (strain CC9902).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus;
OC   unclassified Synechococcus.
OX   NCBI_TaxID=316279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CC9902;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Martinez M., Schmutz J., Larimer F.,
RA   Land M., Kyrpides N., Ivanova N., Richardson P.;
RT   "Complete sequence of Synechococcus sp. CC9902.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABB26079.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000097; ABB26079.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_041424984.1; NC_007513.1.
DR   AlphaFoldDB; Q3AXU8; -.
DR   SMR; Q3AXU8; -.
DR   STRING; 316279.Syncc9902_1115; -.
DR   EnsemblBacteria; ABB26079; ABB26079; Syncc9902_1115.
DR   KEGG; sye:Syncc9902_1115; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_3; -.
DR   OrthoDB; 1036075at2; -.
DR   Proteomes; UP000002712; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..661
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000264964"
FT   DOMAIN          26..105
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          215..250
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   661 AA;  75497 MW;  2116FC2AC37C89B7 CRC64;
     MADSISGTPL LTQPERLERR LKDIPAEPGC YLMRDGDDRI LYVGKSKTLR SRVRSYFRSR
     HDLSPRIRLM TRQVCEIEFI VTDSEAEALA LESNLIKNHQ PHFNVLLKDD KKYPYLCITW
     SESYPRIFIT RRRRFRSPLD RFYGPYVDVG LLRRTLFLVK RVFPLRQRPR PLHQDRTCLN
     YSIGRCPGVC QEKISSDDYH QTLRKVAMVF QGRSDELQNL LQEQMHKYAD RTDYESAARV
     RDQLQGLDQL TADQKMSLPD SSVSRDVLAL ACDERLAAVQ LFQMRAGKLV GRLGYTADAA
     GLSPGLILQR VIEEHYSQVD AVEVPPQLLV QHPLPQQSLL EEWLTEQRER KVQIHCPQRR
     QKADLIELVQ RNAEFELLRA KQGQEQQALS TEDLAQLLDL PLPPRRIEGY DISHIQGSDA
     VASQVVFIDG LPAKQHYRKY KIQSSSIRAG HSDDFMAMAE IMRRRFRRWA RAKADGLDLG
     ALRQKGGSAL QTDGLNDWPD LVMIDGGKGQ LSAVMEALRE LNLHDDLNVC SLAKQREEVF
     LPGESQPLES EADQLGVALL RRLRDEAHRF AVSFHRQQRG ERMKRSRLSD IPGLGAKRVR
     DLLSHFHSID AIQLASVDTL SKAPGVGPVL AQDIFNFFHP TDENDGLPSS QLEGEQLEHS
     A