ID   UVRC_THEFY              Reviewed;         656 AA.
AC   Q47NB5;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=Tfu_2021;
OS   Thermobifida fusca (strain YX).
OC   Bacteria; Actinobacteria; Streptosporangiales; Nocardiopsaceae;
OC   Thermobifida.
OX   NCBI_TaxID=269800;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YX;
RX   PubMed=17209016; DOI=10.1128/jb.01899-06;
RA   Lykidis A., Mavromatis K., Ivanova N., Anderson I., Land M., DiBartolo G.,
RA   Martinez M., Lapidus A., Lucas S., Copeland A., Richardson P., Wilson D.B.,
RA   Kyrpides N.;
RT   "Genome sequence and analysis of the soil cellulolytic actinomycete
RT   Thermobifida fusca YX.";
RL   J. Bacteriol. 189:2477-2486(2007).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000088; AAZ56054.1; -; Genomic_DNA.
DR   RefSeq; WP_011292444.1; NC_007333.1.
DR   AlphaFoldDB; Q47NB5; -.
DR   SMR; Q47NB5; -.
DR   STRING; 269800.Tfu_2021; -.
DR   EnsemblBacteria; AAZ56054; AAZ56054; Tfu_2021.
DR   KEGG; tfu:Tfu_2021; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_1_1_11; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..656
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000227486"
FT   DOMAIN          16..95
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          208..243
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   656 AA;  73112 MW;  38F294172382556D CRC64;
     MTVRPTLRPK PGSIPTDPGV YRFRDEHGRV IYVGKAKNLR ARLSSYFQDF SALHPRTQTM
     ISTAADVDWT VVNTEVEALQ LEYSWIKEYS PRFNVRYRDD KSYPYLAVTL NEEFPRVQVM
     RGARRRGVRY FGPYSYAWAI RDTVDLLLRV FPVRTCSAGV FKRARSSGRP CLLGYIDKCS
     APCVGRIGVE EYRALAEDFC AFMAGETGRF LRQLEAEMKQ AAAAQEYERA ARIRDDIQAL
     RTVMEKQAVV LGDSTDCDVI AIAEDQLEAA VQVFYVRGGR IRGERGWVVD KVEDVSTGKL
     VEQFLAQTYG GADDEESTTA IPREVLVSAE PADRDAVVAW LSKRRGAAVD VRVPQRGDKR
     ALMETVLKNA EQTLARHKSQ RASDLTTRSK ALAEIAEALG LAEAPLRIEC FDISTLQGEH
     TVASMVVFED GLARKSEYRR FSIRGAEGAD SDVAAMYEVI SRRFTRYLEE SQRVGELDTL
     GESGAPQGAE RKAPRFAYPP NLVVVDGGRP QVAAAQRALD DLGIEDVAVC GLAKRLEEVW
     LPGEEDPIIL PRTSEGLYLL QRVRDEAHRF AISYHRRKRA KALTASVLDD IPGLGPVRRA
     ALLKHFGSVR RLAQATAAEI AEVPGIGERT AQTIYERLTS VEGGQRTQPE NSKADE