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UVRC_THEMA
ID   UVRC_THEMA              Reviewed;         557 AA.
AC   Q9WYA3;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 141.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=TM_0265;
OS   Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS   / MSB8).
OC   Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX   NCBI_TaxID=243274;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX   PubMed=10360571; DOI=10.1038/20601;
RA   Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA   Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA   Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA   Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA   Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA   Smith H.O., Venter J.C., Fraser C.M.;
RT   "Evidence for lateral gene transfer between Archaea and Bacteria from
RT   genome sequence of Thermotoga maritima.";
RL   Nature 399:323-329(1999).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; AE000512; AAD35353.1; -; Genomic_DNA.
DR   PIR; H72400; H72400.
DR   RefSeq; NP_228078.1; NC_000853.1.
DR   RefSeq; WP_004082969.1; NZ_CP011107.1.
DR   PDB; 1YCZ; X-ray; 1.80 A; A=1-96.
DR   PDB; 1YD0; X-ray; 1.50 A; A=1-96.
DR   PDB; 1YD1; X-ray; 1.80 A; A=1-96.
DR   PDB; 1YD2; X-ray; 1.60 A; A=1-96.
DR   PDB; 1YD3; X-ray; 1.60 A; A=1-96.
DR   PDB; 1YD4; X-ray; 1.90 A; A=1-96.
DR   PDB; 1YD5; X-ray; 1.80 A; A=1-96.
DR   PDB; 2NRR; X-ray; 1.20 A; A=345-502.
DR   PDB; 2NRT; X-ray; 1.50 A; A=339-557.
DR   PDB; 2NRV; X-ray; 1.80 A; A/B=339-557.
DR   PDB; 2NRW; X-ray; 2.30 A; A=339-557.
DR   PDB; 2NRX; X-ray; 1.90 A; A/B=339-557.
DR   PDB; 2NRZ; X-ray; 2.00 A; A/B=339-557.
DR   PDBsum; 1YCZ; -.
DR   PDBsum; 1YD0; -.
DR   PDBsum; 1YD1; -.
DR   PDBsum; 1YD2; -.
DR   PDBsum; 1YD3; -.
DR   PDBsum; 1YD4; -.
DR   PDBsum; 1YD5; -.
DR   PDBsum; 2NRR; -.
DR   PDBsum; 2NRT; -.
DR   PDBsum; 2NRV; -.
DR   PDBsum; 2NRW; -.
DR   PDBsum; 2NRX; -.
DR   PDBsum; 2NRZ; -.
DR   AlphaFoldDB; Q9WYA3; -.
DR   SMR; Q9WYA3; -.
DR   STRING; 243274.THEMA_03400; -.
DR   EnsemblBacteria; AAD35353; AAD35353; TM_0265.
DR   KEGG; tma:TM0265; -.
DR   eggNOG; COG0322; Bacteria.
DR   InParanoid; Q9WYA3; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   EvolutionaryTrace; Q9WYA3; -.
DR   Proteomes; UP000008183; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IBA:GO_Central.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; DNA damage; DNA excision; DNA repair;
KW   Excision nuclease; Reference proteome; SOS response.
FT   CHAIN           1..557
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000138354"
FT   DOMAIN          14..89
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          194..229
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   HELIX           3..11
FT                   /evidence="ECO:0007829|PDB:1YD0"
FT   STRAND          17..23
FT                   /evidence="ECO:0007829|PDB:1YD0"
FT   STRAND          26..35
FT                   /evidence="ECO:0007829|PDB:1YD0"
FT   HELIX           36..41
FT                   /evidence="ECO:0007829|PDB:1YD0"
FT   HELIX           42..44
FT                   /evidence="ECO:0007829|PDB:1YD0"
FT   HELIX           49..57
FT                   /evidence="ECO:0007829|PDB:1YD0"
FT   STRAND          59..65
FT                   /evidence="ECO:0007829|PDB:1YD0"
FT   HELIX           69..83
FT                   /evidence="ECO:0007829|PDB:1YD0"
FT   HELIX           346..353
FT                   /evidence="ECO:0007829|PDB:2NRR"
FT   STRAND          362..369
FT                   /evidence="ECO:0007829|PDB:2NRR"
FT   TURN            372..374
FT                   /evidence="ECO:0007829|PDB:2NRT"
FT   STRAND          376..384
FT                   /evidence="ECO:0007829|PDB:2NRR"
FT   HELIX           390..392
FT                   /evidence="ECO:0007829|PDB:2NRR"
FT   STRAND          394..398
FT                   /evidence="ECO:0007829|PDB:2NRR"
FT   HELIX           405..417
FT                   /evidence="ECO:0007829|PDB:2NRR"
FT   STRAND          424..430
FT                   /evidence="ECO:0007829|PDB:2NRR"
FT   HELIX           432..444
FT                   /evidence="ECO:0007829|PDB:2NRR"
FT   STRAND          451..454
FT                   /evidence="ECO:0007829|PDB:2NRR"
FT   TURN            456..458
FT                   /evidence="ECO:0007829|PDB:2NRT"
FT   STRAND          461..463
FT                   /evidence="ECO:0007829|PDB:2NRR"
FT   STRAND          466..468
FT                   /evidence="ECO:0007829|PDB:2NRR"
FT   HELIX           475..492
FT                   /evidence="ECO:0007829|PDB:2NRR"
FT   HELIX           493..495
FT                   /evidence="ECO:0007829|PDB:2NRT"
FT   HELIX           496..508
FT                   /evidence="ECO:0007829|PDB:2NRT"
FT   STRAND          511..513
FT                   /evidence="ECO:0007829|PDB:2NRW"
FT   HELIX           516..526
FT                   /evidence="ECO:0007829|PDB:2NRT"
FT   HELIX           529..533
FT                   /evidence="ECO:0007829|PDB:2NRT"
FT   HELIX           537..544
FT                   /evidence="ECO:0007829|PDB:2NRT"
FT   HELIX           547..556
FT                   /evidence="ECO:0007829|PDB:2NRT"
SQ   SEQUENCE   557 AA;  64821 MW;  16B7F10C99212892 CRC64;
     MKEKIRKKIL LAPEEPGVYI FKNKGVPIYI GKAKRLSNRL RSYLNPQTEK VFRIGEEADE
     LETIVVMNER EAFILEANLI KKYRPKYNVR LKDTDFYPYI RISDDEIPYV EIVKRKLWDG
     TYFGPYTSVQ FVRNLLEILQ KIMGFRTCKS DLKRIKRPCF LYHLGRCIGP CIGNIESHEE
     AIRKLREFLS GNMEEVFDYL KEKMETHSKM LDFENAAKYR DLLLNLSNVL ESQGVVFEEN
     INCDVLVHAH DLFVVLRVRN GYLVGKISFE MEGGNVEDFI REYYISGRGD IPKTLILESD
     LDEMDYSSLG FEYVGPPRST TEEDLLEKAK KNLENELKMR GLRKEALEEL MKLLNMKDFP
     YRIEGIDISH LQGKYTVASL VVFEDGFPKK GDYRRYKIEQ DHPDDYESIR TVVKRRYSKH
     PLPNLLFVDG GIGQVNAAIE ALKEIGKDCP VVGLAKKEET VVFENREIHL PHDHPVLRLL
     VQIRDETHRF AVSYHRKRRE KESLRSVLDN VPGIGPIRKK KLIEHFGSLE NIRSASLEEI
     ARVIGSTEIA RRVLDIL
 
 
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