ID   UVRC_THET8              Reviewed;         590 AA.
AC   Q5SI32;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=TTHA1548;
OS   Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8).
OC   Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.
OX   NCBI_TaxID=300852;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27634 / DSM 579 / HB8;
RA   Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T.,
RA   Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.;
RT   "Complete genome sequence of Thermus thermophilus HB8.";
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; AP008226; BAD71371.1; -; Genomic_DNA.
DR   RefSeq; WP_011228755.1; NC_006461.1.
DR   RefSeq; YP_144814.1; NC_006461.1.
DR   AlphaFoldDB; Q5SI32; -.
DR   SMR; Q5SI32; -.
DR   STRING; 300852.55772930; -.
DR   EnsemblBacteria; BAD71371; BAD71371; BAD71371.
DR   GeneID; 3168906; -.
DR   KEGG; ttj:TTHA1548; -.
DR   PATRIC; fig|300852.9.peg.1519; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_0; -.
DR   OMA; HIECFDN; -.
DR   PhylomeDB; Q5SI32; -.
DR   Proteomes; UP000000532; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..590
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000227487"
FT   DOMAIN          11..85
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          194..229
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   590 AA;  67104 MW;  76E944A41BE2E2CC CRC64;
     MRAQDLPPLP ETPGVYLWKR GEEVLYVGKA KSLRARVKSY FHAEGKARRI AEEATGLDFI
     ATRDEVEALL LEANLIKAHR PLYNVLLKDD KHYPFLKLTN EPFPTLLVVR RVEEDGAKYY
     GPFPEAGALR RIKTLIDRLF PLRKNSGYPM KRRRYPCLNY SMGRCLAPCV GKADPEAYQE
     VVRQVEAVLE GRVDGLLQEL EAKMREAARR LEFERAAEIR DQMEALRAFF STDQQAFDPE
     MGDLDFLGMA RSGALAVVQL YQVRSGRILG RISRVVEKEE ATDEEILWAF LRDHYLEASP
     LPPLVLLPFP LEDLESLAEL LKRRAGRKVE LRVPKKGEKA RLLELAERNA RLALETELKL
     RERRGEHPAL KALQDLLGLP ARPWRLEGYD ISHLQGQARV FSIAVFEGGR PKRQEYRRMR
     LKAGNDDYAA MEEGVFRRYT GSLKDLPLPD LLLIDGGVGQ VRAAARALER AGLRLPLVGL
     AKGEEVLVTP EGRELRLPLT HPALQLLIHL RDEAHQNGLR YHRKRRSEEL FRVLQGIPGI
     GEKRRRLLLE RYGGLRALKE APLEELARLP GMSLEAARAL KAALAEEEPA