ID   UVRC_THEVB              Reviewed;         626 AA.
AC   Q8DI39;
DT   16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=tlr1753;
OS   Thermosynechococcus vestitus (strain NIES-2133 / IAM M-273 / BP-1).
OC   Bacteria; Cyanobacteria; Pseudanabaenales; Thermosynechococcaceae;
OC   Thermosynechococcus.
OX   NCBI_TaxID=197221;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIES-2133 / IAM M-273 / BP-1;
RX   PubMed=12240834; DOI=10.1093/dnares/9.4.123;
RA   Nakamura Y., Kaneko T., Sato S., Ikeuchi M., Katoh H., Sasamoto S.,
RA   Watanabe A., Iriguchi M., Kawashima K., Kimura T., Kishida Y., Kiyokawa C.,
RA   Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Sugimoto M.,
RA   Takeuchi C., Yamada M., Tabata S.;
RT   "Complete genome structure of the thermophilic cyanobacterium
RT   Thermosynechococcus elongatus BP-1.";
RL   DNA Res. 9:123-130(2002).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; BA000039; BAC09305.1; -; Genomic_DNA.
DR   RefSeq; NP_682543.1; NC_004113.1.
DR   RefSeq; WP_011057590.1; NC_004113.1.
DR   AlphaFoldDB; Q8DI39; -.
DR   SMR; Q8DI39; -.
DR   STRING; 197221.22295479; -.
DR   EnsemblBacteria; BAC09305; BAC09305; BAC09305.
DR   KEGG; tel:tlr1753; -.
DR   PATRIC; fig|197221.4.peg.1834; -.
DR   eggNOG; COG0322; Bacteria.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   Proteomes; UP000000440; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR041663; DisA/LigA_HHH.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF12826; HHH_2; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..626
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000138352"
FT   DOMAIN          21..100
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          218..253
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   626 AA;  71615 MW;  4888D63D86B1AE6D CRC64;
     MLQPLIQDRD RLEQVLRQLP LAPGVYFLKD KTDQILYIGK SKRLRSRVRS YFREPAQLGP
     RLERMVYQVA EIEFIVTDTE AEALALEANL IKQHQPHFNV LLKDDKKYPY VCITWSEPYP
     RIFITRKRQF GNGGDPRSDS AKDRYYGPYV DSFRLRQTLA LVKRLFPLRQ RPRPLFRDRP
     CLNYDIGRCP GVCQGLISPQ EYRQTLQRVA MIFQGRTGEL VAQLQAQMAQ AAADLNFELA
     ARLRDQIRGL EHLGVDQKVS LPDDTVSRDA IALAVGDRHA AIQLFQIRAG RLVGRLAFVA
     DAQSGSAGTI LQRVLEEHYA QVEDVEIPSE ILLQHPLPEP DFLRTYLSEK KGRAVTLTVP
     QRQAKAELIA MVQRNAELEL ARLQQASDRT QTALEDLAQL LGLDTLPHRI EGYDISHIQG
     SDAVASRVVF IDGLPAQQHY RHYNIRNPEV KLGHSDDFAS LAEILRRRFA PYLEGQGETP
     DDWPDIILID GGKGQLSAVV QVLEPLLEEL TLVSLAKQRE DIFLPHQRQP LPADPEQPGV
     QLLRRVRDEA HRFALNFHRQ KRAQRQRRSH LDQIPGLGYQ RQKELLATFR SIDYIRMATP
     EQLAQVNGVG PRLAARIYRY FHPDAD