ID   UVRC_UREP2              Reviewed;         584 AA.
AC   B1AJ20;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=UPA3_0397;
OS   Ureaplasma parvum serovar 3 (strain ATCC 27815 / 27 / NCTC 11736).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Ureaplasma.
OX   NCBI_TaxID=505682;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27815 / 27 / NCTC 11736;
RA   Methe B.A., Glass J., Waites K., Shrivastava S.;
RT   "Genome sequence of Ureaplasma parvum serovar 3.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000942; ACA33057.1; -; Genomic_DNA.
DR   RefSeq; WP_010891756.1; NC_010503.1.
DR   AlphaFoldDB; B1AJ20; -.
DR   SMR; B1AJ20; -.
DR   EnsemblBacteria; ACA33057; ACA33057; UPA3_0397.
DR   GeneID; 29672651; -.
DR   KEGG; upa:UPA3_0397; -.
DR   HOGENOM; CLU_014841_3_2_14; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   Proteomes; UP000002162; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..584
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_1000077856"
FT   DOMAIN          14..91
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          192..227
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   584 AA;  68026 MW;  2FEBF45ED778E163 CRC64;
     MNDLLKNKLK LIPHKPGCYL WKDQFNQIIY IGKAKDLYNR THSYFNGCKD NKTSKLVNNI
     NDLEYIVVNN VNEALILENN LIKTHLPKYN ILLKDGSNYP YIMITNEQYP RLKYVRTYDK
     NKGIYFGPLA DSTNKYQLFN LLNSIFPFNK CNHQPYKKCI YYDLHQCINQ VQQSTYQEAI
     SEVKEIFKGN LDHILMILQT KEQHAVTKLD FENAQKYAEQ QKALTSIINS GLVQLDNNES
     FDIIGFYEKN NYLVIIIFNY VKGKLLNKSA DTFAIYDYEI NELITSFLMQ YYSQNKISSK
     IIVSLDDDNL LALSQRFHTK FINAQTKFHK RILKLALDNA ILYFESNIKN VINKQNELDD
     ALNQLKQILK LPDLNIIECF DNSNINLSLP IAGMIVYQNG KLNNKLNRKY NLMTTKNASD
     YHFMIEVITR RYQRLVSQHQ KLPNLIVVDG GKLQVNAALY ALAQLQINIP LIGLKKDQKH
     KTDAIVLTNG DEIVLDRKSI LYKFLANMQN DVHNYAISFL RDKHTKSIFN SLLDNVQGLG
     KKRFNELLKY YDSINDLKSA SDQELLQFLP KNVLVNLREK LNKI