ID   UVRC_UREU1              Reviewed;         584 AA.
AC   B5ZBM7;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=UUR10_0424;
OS   Ureaplasma urealyticum serovar 10 (strain ATCC 33699 / Western).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Ureaplasma.
OX   NCBI_TaxID=565575;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33699 / Western;
RA   Shrivastava S., Methe B.A., Glass J., White K., Duffy L.B.;
RT   "Genome sequence of Ureaplasma urealyticum serovar 10 ATCC-33699.";
RL   Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP001184; ACI60242.1; -; Genomic_DNA.
DR   RefSeq; WP_012560321.1; NC_011374.1.
DR   AlphaFoldDB; B5ZBM7; -.
DR   SMR; B5ZBM7; -.
DR   STRING; 565575.UUR10_0424; -.
DR   PRIDE; B5ZBM7; -.
DR   EnsemblBacteria; ACI60242; ACI60242; UUR10_0424.
DR   GeneID; 45015967; -.
DR   KEGG; uue:UUR10_0424; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_14; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   Proteomes; UP000002018; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..584
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_1000099533"
FT   DOMAIN          14..91
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          192..227
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   584 AA;  67934 MW;  C8F7A3773028F12E CRC64;
     MNDLLKTKLK LIPHKPGCYL WKDEFDQIIY IGKAKDLYNR THSYFNGPKD NKTSKLVSNI
     KDLEYIVVNN VNEALILENN LIKTHRPKYN ILLKDGSNYP YIMITNEQYP RLKYVRTYDK
     NKGIYFGPLA DSTNKYQLFN LLNSIFPFNK CNHQPHQKCI YYDLHRCINQ VQPQTYEKAI
     AEVKEIFKGN LDHILAILEN KEQHAVAKLD FENAQKYAEQ QKALTYIINS GLVQLDNNES
     FDVVGFYEKN NYLVIIIFNY VKGKLLNKSA DTFAIYDHEI NELITSFLMQ YYSQNRISTK
     IIVSLDDDNL LALSQRFKTK FINAQTKFHK QILKLAFDNA ILYFDSNIKS VINKQNELDE
     ALNQLKQILK LPDLSMIECF DNSNINLSLP IAGMIVYQNG KLNNKLNRKY NLMTTKNASD
     YHFMIEVITR RYQRLVSQHQ KLPNLIVVDG GKLQVNAALY ALEQLQISIP LIGLKKDQKH
     KTNAIVLANG DEIILDRKSV LYKFLANMQN DVHNYAISFL RNKHTKSIFN SLLNDVQGLG
     KKRLNELLNY YDSINDLKSA SDQELLQFLP KNVLVNLREK LNKI