ID   UVRC_VEREI              Reviewed;         685 AA.
AC   A1WLD5;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=Veis_2700;
OS   Verminephrobacter eiseniae (strain EF01-2).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Verminephrobacter.
OX   NCBI_TaxID=391735;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EF01-2;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T.,
RA   Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.;
RT   "Complete sequence of chromosome 1 of Verminephrobacter eiseniae EF01-2.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000542; ABM58442.1; -; Genomic_DNA.
DR   RefSeq; WP_011810440.1; NC_008786.1.
DR   AlphaFoldDB; A1WLD5; -.
DR   SMR; A1WLD5; -.
DR   STRING; 391735.Veis_2700; -.
DR   PRIDE; A1WLD5; -.
DR   EnsemblBacteria; ABM58442; ABM58442; Veis_2700.
DR   KEGG; vei:Veis_2700; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_0_4; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   Proteomes; UP000000374; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..685
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_1000077857"
FT   DOMAIN          15..93
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          214..249
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   REGION          365..391
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   685 AA;  74644 MW;  111560ACB6FDD4F9 CRC64;
     MHSEELLAQV AALPALPGVY RYFDSQGLLL YVGKARHLKR RVASYFTKNH GGTRIGHMVC
     KIARLETTVV RSEAEALLLE NNLIKTQNPR FNILFRDDKS YPYLKITGAP ASSAGRDAPG
     QRFPRIAYYR GAVDKQHRYF GPYPSAWAVK ESIELLQKVF RLRTCEDTVF ANRTRPCLLY
     QIKRCSGPCV NLIAPEAYAV DVQHAQALLS GQTQELLQAM EARMMAYSGQ LAFEQAAEVR
     NQMQALSRVL HQQSIESAHD KDVDILAVRV QGGRACVNLA MVRGGRHLGD RPYFPTHLED
     AALFEQETRD AEEAPATPPR PVEALVLEAF VAQHYMVVAP PPVLVTSTPL DKALLEALSG
     HLTAAQGGDH APAAQGGDPP PAASSGGHPL RGTVHITAVH QPREQRRAWL EMAQKNADLQ
     LARLLAQEGS QQARTRALAE ALDLPLADLD PLTIECFDIS HTAGEATQAS CVVFHHHKMQ
     SSEYRRYKID GITGGDDYAA MRQVLTRRYG KLAEAAHEAG GVDCAARPAA PAQGQARLPD
     LVLIDGGKGQ VGVAREVFTA LGLDLTRIVG VEKGEGRKVG LEELVFADGR EKASLGKDSA
     ALMLVAQIRD EAHRFAITGM RAARARVRTG GGQLQEIAGV GPKKRARLLQ RFGGVRGVAS
     ASVEDLITVD GISRALAEEI YRALR