UVRC_VIBPA
ID UVRC_VIBPA Reviewed; 610 AA.
AC Q87NC4;
DT 16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT 16-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=VP1944;
OS Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=223926;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RIMD 2210633;
RX PubMed=12620739; DOI=10.1016/s0140-6736(03)12659-1;
RA Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K.,
RA Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S.,
RA Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.;
RT "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism
RT distinct from that of V. cholerae.";
RL Lancet 361:743-749(2003).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC lesion. The N-terminal half is responsible for the 3' incision and the
CC C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC Rule:MF_00203}.
CC -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC {ECO:0000255|HAMAP-Rule:MF_00203}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC Rule:MF_00203}.
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DR EMBL; BA000031; BAC60207.1; -; Genomic_DNA.
DR RefSeq; NP_798323.1; NC_004603.1.
DR RefSeq; WP_011105992.1; NC_004603.1.
DR AlphaFoldDB; Q87NC4; -.
DR SMR; Q87NC4; -.
DR STRING; 223926.28806936; -.
DR EnsemblBacteria; BAC60207; BAC60207; BAC60207.
DR GeneID; 1189455; -.
DR KEGG; vpa:VP1944; -.
DR PATRIC; fig|223926.6.peg.1860; -.
DR eggNOG; COG0322; Bacteria.
DR HOGENOM; CLU_014841_3_0_6; -.
DR OMA; HIECFDN; -.
DR Proteomes; UP000002493; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.420.340; -; 1.
DR Gene3D; 3.40.1440.10; -; 1.
DR HAMAP; MF_00203; UvrC; 1.
DR InterPro; IPR000305; GIY-YIG_endonuc.
DR InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR001943; UVR_dom.
DR InterPro; IPR036876; UVR_dom_sf.
DR InterPro; IPR004791; UvrC.
DR InterPro; IPR001162; UvrC_RNase_H_dom.
DR InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR Pfam; PF01541; GIY-YIG; 1.
DR Pfam; PF02151; UVR; 1.
DR Pfam; PF08459; UvrC_HhH_N; 1.
DR SMART; SM00465; GIYc; 1.
DR SMART; SM00278; HhH1; 2.
DR SUPFAM; SSF46600; SSF46600; 1.
DR SUPFAM; SSF47781; SSF47781; 1.
DR SUPFAM; SSF82771; SSF82771; 1.
DR TIGRFAMs; TIGR00194; uvrC; 1.
DR PROSITE; PS50164; GIY_YIG; 1.
DR PROSITE; PS50151; UVR; 1.
DR PROSITE; PS50165; UVRC; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW Reference proteome; SOS response.
FT CHAIN 1..610
FT /note="UvrABC system protein C"
FT /id="PRO_0000138359"
FT DOMAIN 16..94
FT /note="GIY-YIG"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT DOMAIN 204..239
FT /note="UVR"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ SEQUENCE 610 AA; 69214 MW; C9649786D243AFE1 CRC64;
MNPPFDSASF LKTVTHQPGV YRMYNADAVV IYVGKAKDLQ KRLSSYFRKK VDSEKTRALV
SNIAKIDVTV THTETEALIL EHNYIKQYLP KYNVLLRDDK SYPYILISGH KHPRLSMHRG
AKKRKGEYFG PYPDSGAVRE TLHLLQKIFP VRQCEDTVYS NRTRPCLMYQ IGRCAGPCVS
SIISDEEYAE LVGFVRLFLQ GKDQQVLKQL IEKMEVASQQ LRFEDAAKFR DQIQAIRRVQ
EQQYVSEDSM DDMDVLGFAQ ENGIACIHIL MIRQGKVLGS RSHFPKIPQN TSQQEVFDSF
LTQYYLSHNE ARTIPSRIIL NQELADDLEP IQKALSEVAG RKVHFHTSPT GARGRYLKLS
NTNALTAITT KINHKMTINQ RFKALRETLG MESIMRMECF DISHTMGEST IASCVVFNNE
GPVKQEYRRY NITGITGGDD YAAMGQALER RYSKQLDVEK IPDIIFIDGG KGQLNRAHEI
IAQYWGDWPK RPIMIGIAKG VTRKPGLETL ITVDGEEFNL PSDAPALHLI QHIRDESHNH
AIAGHRAKRG KTRRTSALEG IEGVGPKRRQ ALLKYMGGLQ ELKRASVEEI AKVPGISHSL
AEIIFQALKQ