ID   UVRC_WOLWR              Reviewed;         605 AA.
AC   C0R5B1;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=WRi_000980;
OS   Wolbachia sp. subsp. Drosophila simulans (strain wRi).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Anaplasmataceae; Wolbachieae; Wolbachia; unclassified Wolbachia.
OX   NCBI_TaxID=66084;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=wRi;
RX   PubMed=19307581; DOI=10.1073/pnas.0810753106;
RA   Klasson L., Westberg J., Sapountzis P., Naeslund K., Lutnaes Y.,
RA   Darby A.C., Veneti Z., Chen L., Braig H.R., Garrett R., Bourtzis K.,
RA   Andersson S.G.;
RT   "The mosaic genome structure of the Wolbachia wRi strain infecting
RT   Drosophila simulans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:5725-5730(2009).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP001391; ACN94953.1; -; Genomic_DNA.
DR   RefSeq; WP_006280147.1; NZ_MKIF01000046.1.
DR   AlphaFoldDB; C0R5B1; -.
DR   SMR; C0R5B1; -.
DR   STRING; 66084.WRi_000980; -.
DR   EnsemblBacteria; ACN94953; ACN94953; WRi_000980.
DR   KEGG; wri:WRi_000980; -.
DR   HOGENOM; CLU_014841_3_0_5; -.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000001293; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..605
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_1000200610"
FT   DOMAIN          14..92
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          202..237
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   605 AA;  69861 MW;  5A72983E10A34DFC CRC64;
     MLRQYKEQIK SSPQSCGVYK MVGDKNKVLY VGKAKNLKSR LSDYLQFENL SERIRVMLSQ
     VIKVEIFITE NEIEALLLEA QLIKSLKPLY NIVLKDGKFY PYITISKHDY PRIAKYRGKF
     KKNEFHYYGP FTSAAAVKQT ILSLQKAFLL RVCSDQYFSS TKRPCIEYQI KRCSAPCVDK
     ITKDDYCQSV KQARNTLLGR NKEVKEQLLF TMRKCSSEEN YELAAIYRDR VKFLEQIQIQ
     HTDFSFEKDA DFFSIVREED LACISVLSFR NKDNYGSTPY FAENCGDHSN DEILSTFLVN
     FYNSANIPPI QIYVPDSIVD KEIIEQALYK VAQKPVKVLH AKNKKERDLL KFVYDNSQHS
     LEQKLIDYRN NLEKLEELSK IFLLPNIPKR IEVYDNSHIF GNQQIGVMVV AGQEGFLKSE
     YRKFTIKEKF SGDDYKMMRE VLTRRFSGNI KGIIPDFLLI DGGPGHVSIV QNVLEVLNIN
     VPFACMAKGP DRNAGNERFY MLGREEFSLA NDSKVMLYLQ SLRNEAHRFA ITSHRKKRDK
     QFIVSQLSKI PGIGNKRKKA LMSYFGSVKN ISKASLAEIQ NIPGISKGLA EVILKHVNYK
     RGVLE