ID   UVRC_XYLF2              Reviewed;         621 AA.
AC   B2I637;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203};
GN   OrderedLocusNames=XfasM23_1410;
OS   Xylella fastidiosa (strain M23).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Xylella.
OX   NCBI_TaxID=405441;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M23;
RX   PubMed=20601474; DOI=10.1128/jb.00651-10;
RA   Chen J., Xie G., Han S., Chertkov O., Sims D., Civerolo E.L.;
RT   "Whole genome sequences of two Xylella fastidiosa strains (M12 and M23)
RT   causing almond leaf scorch disease in California.";
RL   J. Bacteriol. 192:4534-4534(2010).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP001011; ACB92825.1; -; Genomic_DNA.
DR   RefSeq; WP_004089558.1; NC_010577.1.
DR   AlphaFoldDB; B2I637; -.
DR   SMR; B2I637; -.
DR   PRIDE; B2I637; -.
DR   EnsemblBacteria; ACB92825; ACB92825; XfasM23_1410.
DR   KEGG; xfn:XfasM23_1410; -.
DR   HOGENOM; CLU_014841_3_0_6; -.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000001698; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..621
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_1000099537"
FT   DOMAIN          20..98
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          207..242
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   621 AA;  68897 MW;  FC676FD376C363F4 CRC64;
     MTDNAPITFD GKRFAAHLST APGVYRMYAA DDTLLYVGKA GALRKRVASY FNGTPKNTRL
     TAMLAQVVRM DVTITRNEAE ALLLENQLIK SLTPRYNVLL RDDKSYPYVL LTREAWPRIA
     LHRGPQIVPG RYFGPYPGVT AVRDMLNLIH KLFKLRSCED SVFRNRSRPC LQYQIGRCSA
     PCVNVVTHDN YTEAVHRVTL FLEGKSDLLA EELIQAMQVA SEHLEFEQAA RLRDLLTSLR
     SMQNRQYVDG RAADLDVLAC AALSGHACVL LLSFRDGRNL GTRMFFPKTN GEERTAEILS
     AFVSQYYAEY PPPPEILLDQ EIPDHTLLEA AFSRSSAHKI SLRWNVRGER AGYVELAVRN
     AQVALSTELT SQRAQRVRSE AVRQLLGLEG PIKRVECFDI SHTMGEATVA SCVVFDAVGP
     VRSQYRRYNI TGITPGDDYA AMRQAIERRF RRAVEEDKQG ERPDVLFIDG GAGQLAQAKM
     ALNAVGVESV LLVGVSKGEE RRAGHETLIM LDGQELHPGA ASPALQFIQQ VRDEAHRFAI
     TGHRARRQKT RMTSKLEDIP GIGSRRRANL LKHFGGLAGV KAAGQTEIAR VEGISTALAA
     KIYASLHGLS KNDAANASRV S