ID   CAF4_CANGA              Reviewed;         579 AA.
AC   Q6FLI3;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=CCR4-associated factor 4 homolog;
GN   Name=CAF4; OrderedLocusNames=CAGL0L03201g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in mitochondrial fission. Has a partially redundant
CC       function to MDV1 in acting as an adapter protein required to form
CC       mitochondrial fission complexes. Formation of these complexes is
CC       required to promote constriction and fission of the mitochondrial
CC       compartment at a late step in mitochondrial division (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat MDV1/CAF4 family. {ECO:0000305}.
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DR   EMBL; CR380958; CAG61881.1; -; Genomic_DNA.
DR   RefSeq; XP_448911.1; XM_448911.1.
DR   AlphaFoldDB; Q6FLI3; -.
DR   SMR; Q6FLI3; -.
DR   STRING; 5478.XP_448911.1; -.
DR   EnsemblFungi; CAG61881; CAG61881; CAGL0L03201g.
DR   GeneID; 2890850; -.
DR   KEGG; cgr:CAGL0L03201g; -.
DR   CGD; CAL0135204; CAGL0L03201g.
DR   VEuPathDB; FungiDB:CAGL0L03201g; -.
DR   eggNOG; KOG4155; Eukaryota.
DR   HOGENOM; CLU_470885_0_0_1; -.
DR   InParanoid; Q6FLI3; -.
DR   Proteomes; UP000002428; Chromosome L.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 3.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 4.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..579
FT                   /note="CCR4-associated factor 4 homolog"
FT                   /id="PRO_0000330610"
FT   REPEAT          278..320
FT                   /note="WD 1"
FT   REPEAT          321..360
FT                   /note="WD 2"
FT   REPEAT          373..412
FT                   /note="WD 3"
FT   REPEAT          419..472
FT                   /note="WD 4"
FT   REPEAT          473..510
FT                   /note="WD 5"
FT   REPEAT          512..539
FT                   /note="WD 6"
FT   REPEAT          540..578
FT                   /note="WD 7"
FT   COILED          137..167
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   579 AA;  64608 MW;  0F66FA05A02128F0 CRC64;
     MVNIVEKQNR LSLISLSLVS IRYKSWDFLY RILHGSIFDY IIGPRKELLL YFKCVYDSTF
     FNGKNYFSNL FTDTATSFRL LTFLNEHDLK SIPPLPLDKC QGLDSYSTLY DGYIVQSSHE
     SQGLYDGSGK DGNDYTMKMQ IMKNVLEMQI NEMDDEIKRI KLRRNVVAKK LDVIISRIVD
     HKENKSKTDG STEDEVHIGN TSSVLKQTNH EHTIITSENN TDDKVSLLTL EPDNAQIGNK
     LQRYFEAMKL KKKSSGFDIE DFENIIGTKG QLGKTLKCHD DYINSLAINA QLGVLSSTAN
     LDNEIKLWDI STTQCLGVLS GHRATVNTTR FIDDTRLLAS AGKDASVKVW DVDNIVDKDG
     NANDNLCLAT FDGHKDSVTA LATTGNAIVS GSNDKTLRHW DLGSGKCIQS IDLTIALKMV
     PQSVSKLDIT PSFNTPLIGG ADCIDNALVT GTKDGIVYLW DLRIGRVVGS LEGHRGPITS
     LKYMGSELIT GSMDKSTRIW DLRMGSVAEL LSFEKEVVSV EESQTQLINA LEGEPVKIYD
     RGERQYNSLP DSFNTTTLVV YESLLALGND HGDITWWSL