ID   UVRC_YERPA              Reviewed;         610 AA.
AC   Q1C8L1;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 2.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=YPA_1244;
OS   Yersinia pestis bv. Antiqua (strain Antiqua).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=360102;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Antiqua;
RX   PubMed=16740952; DOI=10.1128/jb.00124-06;
RA   Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M.,
RA   Worsham P., Chu M.C., Andersen G.L.;
RT   "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516:
RT   evidence of gene reduction in an emerging pathogen.";
RL   J. Bacteriol. 188:4453-4463(2006).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABG13211.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000308; ABG13211.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_002220477.1; NZ_CP009906.1.
DR   AlphaFoldDB; Q1C8L1; -.
DR   SMR; Q1C8L1; -.
DR   PRIDE; Q1C8L1; -.
DR   EnsemblBacteria; ABG13211; ABG13211; YPA_1244.
DR   GeneID; 57976715; -.
DR   KEGG; ypa:YPA_1244; -.
DR   Proteomes; UP000001971; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..610
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000264980"
FT   DOMAIN          16..94
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          204..239
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   610 AA;  68693 MW;  F293BCE633F76E7B CRC64;
     MTDLFDYKEF LKTVTSQPGV YRMYDTAGTV IYVGKAKDLK KRLTSYFRAQ VANRKTETLV
     KNIAQIDVTV THTETEALLL EHNYIKLYQP RYNVLLRDDK SYPLIFLSAD EHPRLAVHRG
     AKHEKGEYFG PFPNSYAVRE TLALLQKLFP VRQCENSVYR NRSRPCLQYQ IGRCSGPCVE
     GLVSEEEYQR QVDYVRLFLS GKDQQVLTQL ITRMEEASQQ LHFEDAARIR DQIQAVRRVT
     EQQFVSGDSE DLDVIGVAFD AGLACVHVLF IRLGKVLGSR SYFPKVPAGT ELSEVVQTFV
     GQFYLQGSQG RTLPGEILLD FTLTEKDLLA SSLSELAGRK IQIQSRPRGD RARYLKLART
     NASTALITRL SQQSTIHQRM KELAKVLKLD EINRMECFDI SHTMGEQTVA SCVVFDANGP
     VRSEYRRYNI SGITPGDDYA AMAQVLKRRY GKALDDQKIP DVIFIDGGKG QLSQAFDVFA
     SLNVPWDKQK PLLVGVAKGS DRKAGLETLF LASEGEGFSL PPDSPALHLI QHIRDDSHNH
     AITGHRQRRS KVKNTSALEM IEGVGPKRRQ VLLKYMGGLQ PLFNASVEEI AKVPGISQAL
     AEKIHNALKH