ID   CAF4_VANPO              Reviewed;         669 AA.
AC   A7TNS8;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=CCR4-associated factor 4 homolog;
GN   Name=CAF4; ORFNames=Kpol_1016p11;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Involved in mitochondrial fission. Has a partially redundant
CC       function to MDV1 in acting as an adapter protein required to form
CC       mitochondrial fission complexes. Formation of these complexes is
CC       required to promote constriction and fission of the mitochondrial
CC       compartment at a late step in mitochondrial division (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat MDV1/CAF4 family. {ECO:0000305}.
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DR   EMBL; DS480434; EDO16071.1; -; Genomic_DNA.
DR   RefSeq; XP_001643929.1; XM_001643879.1.
DR   AlphaFoldDB; A7TNS8; -.
DR   SMR; A7TNS8; -.
DR   STRING; 436907.A7TNS8; -.
DR   EnsemblFungi; EDO16071; EDO16071; Kpol_1016p11.
DR   GeneID; 5544194; -.
DR   KEGG; vpo:Kpol_1016p11; -.
DR   eggNOG; KOG4155; Eukaryota.
DR   HOGENOM; CLU_012350_1_0_1; -.
DR   InParanoid; A7TNS8; -.
DR   OrthoDB; 927943at2759; -.
DR   PhylomeDB; A7TNS8; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..669
FT                   /note="CCR4-associated factor 4 homolog"
FT                   /id="PRO_0000330611"
FT   REPEAT          351..391
FT                   /note="WD 1"
FT   REPEAT          394..433
FT                   /note="WD 2"
FT   REPEAT          453..492
FT                   /note="WD 3"
FT   REPEAT          516..557
FT                   /note="WD 4"
FT   REPEAT          558..595
FT                   /note="WD 5"
FT   REPEAT          597..634
FT                   /note="WD 6"
FT   REPEAT          640..669
FT                   /note="WD 7"
FT   COILED          189..222
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   669 AA;  76622 MW;  A143EF72A249428D CRC64;
     MVGLHFDRGP VKHVDIGWRV PNLLRELLDG IGKEYSLQKC IPITVLEKVL WKYQSIDNVA
     ALSGKEYSRV QLCGPKCAFR ILCNIPSDQL VIPDIEKYNE FNVNKTLYEG FLLALDTIQH
     TFNSQLFNDS PPHELNSKAE SSVSHTAEDY FDSYISNFSR ISETNLEKLH SRRELKNIEC
     DAKKSLKILN AYDKLYDDQL DELEKKLEDI QYKQHALRQK KGTILSTSEK LNNMIYISKQ
     SRKNIEEVSL LLKYDMNKKS SSVYSGWETT NLLSKSELAF GFNENNNNYN DDSLGEEDAN
     DESENYDTFN LEGKNSRYSG SSVDYISEDT RQQKAKNKHE IGTVLSALKN AHENNITCLD
     FDEPFGTLYS AGQLDNTIKV WDLSSSKFIG SFNAHLSTIN CMQLDTQQQI IISGGRDSLV
     RLWDIKKFQD YSTNYNDIEN YYEETNCIFE CDSHSDEISS ISYDNFNLLT GSQDKTIKHW
     DLITGKCVQT FDVSFYLNNS PPFENKFSPT KKNYFAHSEA PTIGSLQCFE SALASGTKDG
     LIRLWDLRSG KVIRILEGHT DAITSLKFDM TNLITGSLDK NIRIWDMRNW SLVNSYGYQS
     PVWSLDFNSA NVVSATGGKT SEIFRRKENN HCIPNENYSF IKSEVQFVKY KEDWLIEGRS
     NGDIEILTI