ID   UVRD_MYCCT              Reviewed;         722 AA.
AC   P45612; Q2SRD6;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 2.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Probable DNA helicase II homolog;
DE            EC=3.6.4.12;
GN   Name=uvrD; Synonyms=pcrA; OrderedLocusNames=MCAP_0717;
OS   Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343
OS   / NCTC 10154).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=340047;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=California kid / ATCC 27343 / NCTC 10154;
RA   Glass J.I., Lartigue C., Pfannkoch C., Baden-Tillson H., Smith H.O.,
RA   Venter J.C., Roske K., Wise K.S., Calcutt M.J., Nelson W.C., Nierman W.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 541-722.
RX   PubMed=8253782; DOI=10.1016/s0021-9258(19)74345-2;
RA   Zhu P.-P., Reizer J., Reizer A., Peterkofsky A.;
RT   "Unique monocistronic operon (ptsH) in Mycoplasma capricolum encoding the
RT   phosphocarrier protein, HPr, of the phosphoenolpyruvate:sugar
RT   phosphotransferase system. Cloning, sequencing, and characterization of
RT   ptsH.";
RL   J. Biol. Chem. 268:26531-26540(1993).
CC   -!- FUNCTION: Has both ATPase and helicase activities. Unwinds DNA duplexes
CC       with 3' to 5' polarity with respect to the bound strand and initiates
CC       unwinding most effectively when a single-stranded region is present.
CC       Involved in the post-incision events of nucleotide excision repair and
CC       methyl-directed mismatch repair (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CP000123; ABC01643.1; -; Genomic_DNA.
DR   EMBL; L22432; AAA16212.1; -; Unassigned_DNA.
DR   PIR; D49683; D49683.
DR   RefSeq; WP_011387561.1; NC_007633.1.
DR   AlphaFoldDB; P45612; -.
DR   SMR; P45612; -.
DR   EnsemblBacteria; ABC01643; ABC01643; MCAP_0717.
DR   GeneID; 23778329; -.
DR   KEGG; mcp:MCAP_0717; -.
DR   HOGENOM; CLU_004585_5_2_14; -.
DR   OMA; YQDTNRT; -.
DR   OrthoDB; 137860at2; -.
DR   PhylomeDB; P45612; -.
DR   Proteomes; UP000001928; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.160; -; 1.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070; PTHR11070; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA replication; DNA-binding;
KW   Helicase; Hydrolase; Nucleotide-binding.
FT   CHAIN           1..722
FT                   /note="Probable DNA helicase II homolog"
FT                   /id="PRO_0000102075"
FT   DOMAIN          8..291
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00560"
FT   DOMAIN          292..565
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00617"
FT   BINDING         32..37
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00560"
FT   BINDING         289
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   722 AA;  83641 MW;  64492D9FF891D2E5 CRC64;
     MSVDNLLDLL NDQQLAAVLN IDKPVRIIAG AGSGKTRVIT TKIAYLIEKQ NIDPSRILAV
     TFTNKAAKEM KERVLQITNN SFKSPFISTF HSWCSKVLRI DGKHIGLEDK FLIIDSDDQK
     RIIKSALKES NIELSENDKK TFDKKILYKI KEWKEELVDP SEAILNATST LEKNFAVIYR
     LYQNTLLKNN SLDFDDLQIY VYRLFKQNNE ILNKWRNAYD YVLVDEFQDT NELQFSLIKF
     LTINTNHLTV VGDPDQTIYS WRGAKLDIIL NFNKTYSNAI SIVLNQNYRS TKQILDISNS
     FIKNNKFREH KEIFTNNKSG KKVVLKECNS KTSEASYVSS KIKELVKQGY HYKDIFILYR
     MNAWSQEFEK ELANKKIPFQ LIGGIKFRER KVIKDAMAFL KMISIKDNLS SQRVLGLIPK
     IGNITIEKII NTANLNHLNI FDLITNEDKT LLHSITKNLD ELIEVFKTAH QLYLDNTNIE
     EILKYLLIQS GYENKLKIRK EQDDLENINA LYDQLKRFDE DFDPKYYSEE NKLIAFLQEE
     ALTSDIDEAE QIDKVSLLTV HAAKGLENKV VFITGLNQGI FPSRISETSI NELEEERRAL
     YVALTRAKDE LFLTYVKGDY SHIMQSELKP SKFIHELDKD LYEFETQFLN TLLYDSNDYK
     QSSFYVSPKQ HNLYNVGDHV EHKLFGKGVV VKIINDQLQI SFTNSSYGIM MIATNNSALS
     KV