ID   UVRD_MYCGE              Reviewed;         703 AA.
AC   P47486;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Probable DNA helicase II homolog;
DE            EC=3.6.4.12;
GN   Name=uvrD; OrderedLocusNames=MG244;
OS   Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)
OS   (Mycoplasmoides genitalium).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=243273;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX   PubMed=7569993; DOI=10.1126/science.270.5235.397;
RA   Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A.,
RA   Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M.,
RA   Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L.,
RA   Nguyen D.T., Utterback T.R., Saudek D.M., Phillips C.A., Merrick J.M.,
RA   Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S.,
RA   Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C.;
RT   "The minimal gene complement of Mycoplasma genitalium.";
RL   Science 270:397-403(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 277-345.
RC   STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX   PubMed=1945886; DOI=10.1093/nar/19.21.6027;
RA   Peterson S.N., Schramm N., Hu P.-C., Bott K.F., Hutchison C.A. III;
RT   "A random sequencing approach for placing markers on the physical map of
RT   Mycoplasma genitalium.";
RL   Nucleic Acids Res. 19:6027-6031(1991).
CC   -!- FUNCTION: Has both ATPase and helicase activities. Unwinds DNA duplexes
CC       with 3' to 5' polarity with respect to the bound strand and initiates
CC       unwinding most effectively when a single-stranded region is present.
CC       Involved in the post-incision events of nucleotide excision repair and
CC       methyl-directed mismatch repair (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000305}.
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DR   EMBL; L43967; AAC71464.1; -; Genomic_DNA.
DR   EMBL; X61517; CAA43729.1; -; Genomic_DNA.
DR   PIR; I64226; I64226.
DR   RefSeq; WP_010869390.1; NC_000908.2.
DR   AlphaFoldDB; P47486; -.
DR   SMR; P47486; -.
DR   STRING; 243273.MG_244; -.
DR   EnsemblBacteria; AAC71464; AAC71464; MG_244.
DR   KEGG; mge:MG_244; -.
DR   eggNOG; COG0210; Bacteria.
DR   HOGENOM; CLU_004585_6_1_14; -.
DR   OMA; RLEYIMI; -.
DR   OrthoDB; 137860at2; -.
DR   BioCyc; MGEN243273:G1GJ2-291-MON; -.
DR   Proteomes; UP000000807; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0033202; C:DNA helicase complex; IBA:GO_Central.
DR   GO; GO:0043138; F:3'-5' DNA helicase activity; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0000725; P:recombinational repair; IBA:GO_Central.
DR   Gene3D; 1.10.10.160; -; 1.
DR   Gene3D; 3.40.50.300; -; 3.
DR   InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070; PTHR11070; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA replication; DNA-binding;
KW   Helicase; Hydrolase; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..703
FT                   /note="Probable DNA helicase II homolog"
FT                   /id="PRO_0000102076"
FT   DOMAIN          1..287
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00560"
FT   DOMAIN          294..542
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00617"
FT   BINDING         23..28
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00560"
FT   BINDING         285
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   703 AA;  81959 MW;  14D925E1F7C6525B CRC64;
     MNEQQKQAIS CGKGVNVVYS GAGTGKTTII TNRFAYLVNK EKVDPSRILA ITFTKKAAKE
     MQFRILKLID SSLAEKTNIY TFHSFCNKFL IQTLKKRFII DDDISYFLKE FLADSKLDIN
     LAKQIIDNFK NTFADFEINK LDQDERLISL CEHSLLNKDE EYSTLKTQLI NAFISYEKNK
     ILNNKLDFHD LLIKTCNLLS NDNDLLNQWS EQFQHILVDE FQDTNQIQYE LIKMLVTKNK
     NLFLVGDNNQ MIYRWRGAVN GIITALKHDF NVPKSNEFFI NQNYRCDQNI LAVANQILLK
     IMAYEKQVKT EKNLLFSTLN SDKKPVYFQA ESVENQANWI FNKIKALNQT EKINFKDMAI
     LFRKNRDITT MVELIEADGT IPLPKQKSYF NQLVKLQRVL IAISTRTNLD IKRALQALKI
     WSNDLKELWK QSDKTNLFDF LKWSELNQKN HSSKLKATGY FNLLIKLAED QQINLLFTEL
     FKKLKVDQTI ENLLWKKLTE FQKDKTEFSL SEFITSLALE FDSIIENSSD TINLLTVHAA
     KGLEFEAVFI YGMNQGDFPL FLSQNQNDEQ HLIDELKLFY VAITRAKRFL FITAVLQINN
     NSIKPSSFLN YINKSEYLDI ATINYVLEQD DDFFDSTKKT DYTKKLRKES LDIIVGDLVT
     SRYFGKGVVV EVRDKEVLVA FKDTRYGMKW ILKNHKSLTK ALY