ID   UVRD_MYCPN              Reviewed;         715 AA.
AC   P75437;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Probable DNA helicase II homolog;
DE            EC=3.6.4.12;
GN   Name=uvrD; OrderedLocusNames=MPN_341; ORFNames=MP495;
OS   Mycoplasma pneumoniae (strain ATCC 29342 / M129) (Mycoplasmoides
OS   pneumoniae).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=272634;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29342 / M129;
RX   PubMed=8948633; DOI=10.1093/nar/24.22.4420;
RA   Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.;
RT   "Complete sequence analysis of the genome of the bacterium Mycoplasma
RT   pneumoniae.";
RL   Nucleic Acids Res. 24:4420-4449(1996).
CC   -!- FUNCTION: Has both ATPase and helicase activities. Unwinds DNA duplexes
CC       with 3' to 5' polarity with respect to the bound strand and initiates
CC       unwinding most effectively when a single-stranded region is present.
CC       Involved in the post-incision events of nucleotide excision repair and
CC       methyl-directed mismatch repair (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U00089; AAB96143.1; -; Genomic_DNA.
DR   PIR; S73821; S73821.
DR   RefSeq; NP_110029.1; NC_000912.1.
DR   RefSeq; WP_010874697.1; NC_000912.1.
DR   AlphaFoldDB; P75437; -.
DR   SMR; P75437; -.
DR   IntAct; P75437; 2.
DR   STRING; 272634.MPN_341; -.
DR   EnsemblBacteria; AAB96143; AAB96143; MPN_341.
DR   GeneID; 66609003; -.
DR   KEGG; mpn:MPN_341; -.
DR   PATRIC; fig|272634.6.peg.365; -.
DR   HOGENOM; CLU_004585_6_1_14; -.
DR   OMA; HCANILI; -.
DR   BioCyc; MPNE272634:G1GJ3-538-MON; -.
DR   Proteomes; UP000000808; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.160; -; 1.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070; PTHR11070; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA replication; DNA-binding;
KW   Helicase; Hydrolase; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..715
FT                   /note="Probable DNA helicase II homolog"
FT                   /id="PRO_0000102077"
FT   DOMAIN          7..295
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00560"
FT   DOMAIN          296..554
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00617"
FT   BINDING         31..36
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00560"
FT   BINDING         293
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   715 AA;  83497 MW;  D68896507E933181 CRC64;
     MAFNISTQLN KEQRAAVTCG KGVNIVYSGA GTGKTTIISQ RFAYLFNQKR INPSNILALT
     YTRKAASEMK QRILELLPEK YHKDVNIYTF HSFCSRFLRE EGQKNFVIDD DLSNFLKDFL
     KESELKSQKV LQIIDGFKNA YFDFDTNSLK DDERLVELCE FHLDPQERNF QLFKETAIAA
     FVEYEKGKQQ NNKIDFADLL IKTCTLLSKD HKLLRKWSKK FQYILGDEFQ DTNQIQYELI
     KMLASHHQNL FLVGDNNQMI YRWRGAVSDI IDSLKSDFKV RPENEFYITQ NYRCDQNILT
     VANSILGTIY AKENQPDSTK GFLFSAIKSN RLPVYFQASS VEGQHSWIIN KIKNLHKNHG
     IQYKDMAILF RTNRNMDSMT EALEADGSIP LKQNKGFFKQ LETFKKVLVA LITRSNYDIK
     LALKSLRVWP NVLNKSLTVN EQVNLDKILQ NLEQAIFLDE HTRGELTEAA KVFTRLIKFV
     EEQQFEALLA FTFEALNTDQ FVCNFIFRTL QKLQTENKNF TITDFINELR FQQDELKQSK
     DNVINLITVH SAKGLEFEAV FIYGINQDNF PLKSKNQIID LQRELDELRL FYVALTRAKK
     YLFLLSVYQM SGEIIYPSKF IRFINKEDRL EIATINHKVH QDDEFFDSSK TEDYQKKYLT
     ENTDFVNGDS VSHRTYGKGV VVEVREDAVC VAFKNSKYGQ RWIVKNHRDL VKAVY