UVRD_RICBR
ID UVRD_RICBR Reviewed; 653 AA.
AC Q1RIP8;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Probable DNA helicase II homolog;
DE EC=3.6.4.12;
GN Name=uvrD; OrderedLocusNames=RBE_0685;
OS Rickettsia bellii (strain RML369-C).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC Rickettsiaceae; Rickettsieae; Rickettsia; belli group.
OX NCBI_TaxID=336407;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RML369-C;
RX PubMed=16703114; DOI=10.1371/journal.pgen.0020076;
RA Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C.,
RA Fournier P.-E., Claverie J.-M., Raoult D.;
RT "Genome sequence of Rickettsia bellii illuminates the role of amoebae in
RT gene exchanges between intracellular pathogens.";
RL PLoS Genet. 2:733-744(2006).
CC -!- FUNCTION: Has both ATPase and helicase activities. Unwinds DNA duplexes
CC with 3' to 5' polarity with respect to the bound strand and initiates
CC unwinding most effectively when a single-stranded region is present.
CC Involved in the post-incision events of nucleotide excision repair and
CC methyl-directed mismatch repair (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000305}.
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DR EMBL; CP000087; ABE04766.1; -; Genomic_DNA.
DR RefSeq; WP_011477354.1; NC_007940.1.
DR AlphaFoldDB; Q1RIP8; -.
DR SMR; Q1RIP8; -.
DR STRING; 336407.RBE_0685; -.
DR EnsemblBacteria; ABE04766; ABE04766; RBE_0685.
DR KEGG; rbe:RBE_0685; -.
DR eggNOG; COG0210; Bacteria.
DR HOGENOM; CLU_004585_5_10_5; -.
DR OMA; YQDTNRT; -.
DR OrthoDB; 137860at2; -.
DR Proteomes; UP000001951; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:InterPro.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR005751; ATP-dep_DNA_helicase_PcrA.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070; PTHR11070; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR01073; pcrA; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA replication; DNA-binding;
KW Helicase; Hydrolase; Nucleotide-binding.
FT CHAIN 1..653
FT /note="Probable DNA helicase II homolog"
FT /id="PRO_0000286458"
FT DOMAIN 8..288
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00560"
FT DOMAIN 289..559
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00617"
FT BINDING 32..37
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00560"
FT BINDING 286
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
SQ SEQUENCE 653 AA; 74913 MW; F9E664370E021754 CRC64;
MPNHDFLHSL NEQQQKAVLH TEGPLLLLAG AGTGKTKVLT SRIANIIHQN LASPQNILAV
TFTNKAAKEM QERVHNLVSS YGLNIGTFHS MAARILRDQI EHLNLGLNSR FTIISQDDQL
RLIKDIVKLK NIDTKKYAPK LIHIVISRWK DQGLLPNKLS SSDTNLPLQR VAKLVYEEYQ
QNLLISNVVD FGDLLLYNNE LFIKNPDILK HYQERYRYIL IDEYQDTNVV QYLWARMLAS
LSKNICCVGD DDQSIYGWRG AEVGNILRFE KDFLNATIIK LEQNYRSTLP ILAAASNVIN
NNKNRHGKTL WTDKESGEKI KIISCWNDKE EARYIAAEIA RLVREGRYSA GNIAILVRAG
FQTRSFEEAF INSAMPYKII GGLRFYERME IRDVLAYIRI ALNQNDNLAL ERIINVPKRA
IGAVTLNKIK LYAIEKNISN FAAIKEMLED GEIKTKSYET LKDLVTKISN WHERFSFDAP
INVTKAILDD SGYLEMLQEE KTEEALGRIE NINEMLRAIA EFNDIHDFIE HSSLVMENES
LETSYGGSVT IMTLHGAKGL EFDVVFLPGW EEGVFPSQRS LDEEGEKGLE EERRIAYVGI
TRAKKELYIT HAESRKIFYE IVRSYPSRFL AEIPEEIIIR TSSIKKYDSF YKF