ID   UVRD_RICFE              Reviewed;         654 AA.
AC   Q4ULN5;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Probable DNA helicase II homolog;
DE            EC=3.6.4.12;
GN   Name=uvrD; OrderedLocusNames=RF_0687;
OS   Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=315456;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-1525 / URRWXCal2;
RX   PubMed=15984913; DOI=10.1371/journal.pbio.0030248;
RA   Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E.,
RA   Parinello H., Claverie J.-M., Raoult D.;
RT   "The genome sequence of Rickettsia felis identifies the first putative
RT   conjugative plasmid in an obligate intracellular parasite.";
RL   PLoS Biol. 3:1-12(2005).
CC   -!- FUNCTION: Has both ATPase and helicase activities. Unwinds DNA duplexes
CC       with 3' to 5' polarity with respect to the bound strand and initiates
CC       unwinding most effectively when a single-stranded region is present.
CC       Involved in the post-incision events of nucleotide excision repair and
CC       methyl-directed mismatch repair (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CP000053; AAY61538.1; -; Genomic_DNA.
DR   RefSeq; WP_011271017.1; NC_007109.1.
DR   AlphaFoldDB; Q4ULN5; -.
DR   SMR; Q4ULN5; -.
DR   STRING; 315456.RF_0687; -.
DR   PRIDE; Q4ULN5; -.
DR   EnsemblBacteria; AAY61538; AAY61538; RF_0687.
DR   KEGG; rfe:RF_0687; -.
DR   eggNOG; COG0210; Bacteria.
DR   HOGENOM; CLU_004585_5_10_5; -.
DR   OMA; YQDTNRT; -.
DR   OrthoDB; 137860at2; -.
DR   Proteomes; UP000008548; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:InterPro.
DR   Gene3D; 1.10.10.160; -; 1.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR005751; ATP-dep_DNA_helicase_PcrA.
DR   InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070; PTHR11070; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR01073; pcrA; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA replication; DNA-binding;
KW   Helicase; Hydrolase; Nucleotide-binding.
FT   CHAIN           1..654
FT                   /note="Probable DNA helicase II homolog"
FT                   /id="PRO_0000286460"
FT   DOMAIN          9..289
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00560"
FT   DOMAIN          290..560
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00617"
FT   BINDING         33..38
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00560"
FT   BINDING         287
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   654 AA;  75134 MW;  D89AE60D88A8E520 CRC64;
     MLNNQDFIHT LNPQQQKAVL HTKGPLLLLA GAGTGKTKVL TSRIANIVHQ NLASPQNILA
     VTFTNKAAKE MAERVNSLIN CYGLNIGTFH SMAARILRDQ IEHLNLGLNN RFTIISHDDQ
     LKLVKDIVKL KDIDTKKYAP KLIHIIISRW KDQGLLPSKL SASDTNLPLQ RVAKLVYEEY
     QKNLLISNVL DFGDLLLYNN ELFIKNPEIL RYYQEKYRYI LIDEYQDTNV VQYLWARMLA
     SLYKNICCVG DDDQSIYGWR GAEVGNILRF EKDFAGATII KLEQNYRSTL PILAAASNVI
     NNNKNRHGKT LWTDRESGEK IKIISCWSDK EEARYIAGEI DKLVREDRYN AGNIAILVRA
     GFQTRSFEEA FINSAMPYKI IGGLRFYERM EIRDVLAYIR ISLNQNDNLA LERIINVPKR
     AIGAASLNKI RVYALERNIS NFAAIKEMLE MGEIKAKPYE TLKDLVTKID NWHERFSIDA
     PINVVKAILD DSGYLEMLQE EKTEEAFGRI ENINEMLRAI AEFNDIHDFI EHSSLVMENE
     VLETNYGGSV TIMTLHAAKG LEFDVVFLPG WEEGVFPSQR SLDEEGEKGL EEERRIAYVG
     ITRAKKDLYI THAESRKIFY EIVRSYPSRF ITEIPDEITI RTSSMKKYNS FYKF