ID   UVRD_RICPR              Reviewed;         658 AA.
AC   Q9ZD95;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Probable DNA helicase II homolog;
DE            EC=3.6.4.12;
GN   Name=uvrD; OrderedLocusNames=RP447;
OS   Rickettsia prowazekii (strain Madrid E).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX   NCBI_TaxID=272947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Madrid E;
RX   PubMed=9823893; DOI=10.1038/24094;
RA   Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T.,
RA   Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H.,
RA   Kurland C.G.;
RT   "The genome sequence of Rickettsia prowazekii and the origin of
RT   mitochondria.";
RL   Nature 396:133-140(1998).
CC   -!- FUNCTION: Has both ATPase and helicase activities. Unwinds DNA duplexes
CC       with 3' to 5' polarity with respect to the bound strand and initiates
CC       unwinding most effectively when a single-stranded region is present.
CC       Involved in the post-incision events of nucleotide excision repair and
CC       methyl-directed mismatch repair (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AJ235271; CAA14904.1; -; Genomic_DNA.
DR   PIR; F71703; F71703.
DR   RefSeq; NP_220828.1; NC_000963.1.
DR   RefSeq; WP_004599479.1; NC_000963.1.
DR   AlphaFoldDB; Q9ZD95; -.
DR   SMR; Q9ZD95; -.
DR   STRING; 272947.RP447; -.
DR   EnsemblBacteria; CAA14904; CAA14904; CAA14904.
DR   GeneID; 57569572; -.
DR   KEGG; rpr:RP447; -.
DR   PATRIC; fig|272947.5.peg.460; -.
DR   eggNOG; COG0210; Bacteria.
DR   HOGENOM; CLU_004585_5_2_5; -.
DR   OMA; YQDTNRT; -.
DR   Proteomes; UP000002480; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:InterPro.
DR   Gene3D; 1.10.10.160; -; 1.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR005751; ATP-dep_DNA_helicase_PcrA.
DR   InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070; PTHR11070; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR01073; pcrA; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA replication; DNA-binding;
KW   Helicase; Hydrolase; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..658
FT                   /note="Probable DNA helicase II homolog"
FT                   /id="PRO_0000102081"
FT   DOMAIN          12..293
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00560"
FT   DOMAIN          294..564
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00617"
FT   BINDING         36..41
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00560"
FT   BINDING         291
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   658 AA;  75389 MW;  CCFA97690F0E0BDC CRC64;
     MKDKIQNQNF MHTLNAEQKK AALHTEGPLL LLAGAGTGKT KVLTSRIANI IHQNLALPHN
     ILAVTFTNKA AKEMSERVHN LINCYGLNIG TFHSMAAKIL RDQIENLNLG FNNRFTIISH
     DDQLTLVKDI VKLKKDIDAK KYTPKLIHII ISRWKDQGLL PNKLSTSDTN LPLQKIAKLV
     YEEYQKNLLI SNVLDFGDLL LYNNELFIKN PAVLKYYQEK YRYILIDEYQ DTNIAQYLWA
     RMLASLYRNI CCVGDDDQSI YGWRGAEVGN ILRFEKDFAG ATIIKLEQNY RSTLPILAAA
     SNVINNNKNR HSKTLWTDSS SGEKIKIISC LSDKEEARYI ACEIDKLVKE ERYNAGNIAI
     LVRAGFQTRS FEEAFINSAI PYKIIGGLRF YERMEIRDVL AYIRISLNQN DNLALERIIN
     VPKRAIGAAS LNKIRSYALE RNISNFAAIK EILEIGNIKA KSYESLKDLL TKIDNWYEQF
     IIDTPINVVK AILDDSGYLA MLKEEKTEEA FGRIENINEM LRAIAEFNDI HDFIEYSSLV
     MENEVLETNY GGSVTIMTLH AAKGLEFDVV FLPGWEEGVF PSQRSLDEDG EKGLEEERRI
     AYVGITRAKK DLYITHAESR KIFYEIVRSC PSRFINEIPD EITIRTSSMK QYNSFYKF