ID   UVRD_RICTY              Reviewed;         658 AA.
AC   Q68WT1;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=DNA helicase II;
DE            EC=3.6.4.12;
GN   Name=uvrD; OrderedLocusNames=RT0434;
OS   Rickettsia typhi (strain ATCC VR-144 / Wilmington).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX   NCBI_TaxID=257363;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-144 / Wilmington;
RX   PubMed=15317790; DOI=10.1128/jb.186.17.5842-5855.2004;
RA   McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E.,
RA   McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E.,
RA   Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A., Hong C.,
RA   Yu X.-J., Walker D.H., Weinstock G.M.;
RT   "Complete genome sequence of Rickettsia typhi and comparison with sequences
RT   of other Rickettsiae.";
RL   J. Bacteriol. 186:5842-5855(2004).
CC   -!- FUNCTION: Has both ATPase and helicase activities. Unwinds DNA duplexes
CC       with 3' to 5' polarity with respect to the bound strand and initiates
CC       unwinding most effectively when a single-stranded region is present.
CC       Involved in the post-incision events of nucleotide excision repair and
CC       methyl-directed mismatch repair (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE017197; AAU03911.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q68WT1; -.
DR   SMR; Q68WT1; -.
DR   STRING; 257363.RT0434; -.
DR   EnsemblBacteria; AAU03911; AAU03911; RT0434.
DR   KEGG; rty:RT0434; -.
DR   eggNOG; COG0210; Bacteria.
DR   HOGENOM; CLU_004585_5_2_5; -.
DR   OMA; YQDTNRT; -.
DR   Proteomes; UP000000604; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:InterPro.
DR   Gene3D; 1.10.10.160; -; 1.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR005751; ATP-dep_DNA_helicase_PcrA.
DR   InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070; PTHR11070; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR01073; pcrA; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA replication; DNA-binding;
KW   Helicase; Hydrolase; Nucleotide-binding.
FT   CHAIN           1..658
FT                   /note="DNA helicase II"
FT                   /id="PRO_0000286461"
FT   DOMAIN          12..293
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00560"
FT   DOMAIN          294..564
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00617"
FT   BINDING         36..41
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00560"
FT   BINDING         291
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   658 AA;  75502 MW;  165BD9DA57F15914 CRC64;
     MKDKMQNQNF MHTLNSEQKK AALHTEGPLL LLAGAGTGKT KVLTSRIANI IQQNLALPHN
     ILAVTFTNKA AKEMSERVHN LINCYGVNIG TFHSMAAKIL RDQIENLNLG LNNKFTIISH
     DDQLTLVKDI VKLKKDIDTK KYTPKLIHII ISRWKDQGLL PSKLSASDTN LPLQRVAKLI
     YEEYQKNLLI SNVLDFGDLL LYNNELFIKN PEILKYYQEK YRYILIDEYQ DTNIAQYLWA
     RMLASLYRNI CCVGDDDQSI YGWRGAEVGN ILRFEKDFAG ATIIKLEQNY RSTLPILAAA
     SNVINNNKNR HSKTLWTDSA SGEKIKIISC LSDKEEARYI ACEIDKLVRE ERYHAGNIAI
     LVRAGFQTRS FEEAFINSAM PYKIIGGLRF YERMEIRDVL AYIRISLNQN DNLALERIIN
     VPKRAIGAAS LNKIRSYALE RNISNFVAIK EILETGIFKA KSYESLKDLL TKIDNWYEKF
     ITDTPINVVK TILDDSGYLS MLQEEKTEEA FGRIENINEM LRAIAEFNDI HDFIEHSSLV
     MENEVLETNY GGSVTIMTLH AAKGLEFDVV FLPGWEEGVF PSQRSLDEDG EKGLEEERRI
     AYVGITRAKK DLYITHAESR KIFYEIVHSC PSRFINEIPD EITIRTSSMK KYNSFYKF