ID   UVRX_BACSU              Reviewed;         416 AA.
AC   O31990; O30670;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 2.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Putative UV-damage repair protein UvrX;
GN   Name=uvrX; OrderedLocusNames=BSU21500;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9722542; DOI=10.1074/jbc.273.36.23134;
RA   Paik S.H., Chakicherla A., Hansen J.N.;
RT   "Identification and characterization of the structural and transporter
RT   genes for, and the chemical and biological properties of, sublancin 168, a
RT   novel lantibiotic produced by Bacillus subtilis 168.";
RL   J. Biol. Chem. 273:23134-23142(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   SEQUENCE REVISION TO 45.
RX   PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA   Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA   Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT   "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT   168 reference genome a decade later.";
RL   Microbiology 155:1758-1775(2009).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC       Note=Binds 2 magnesium ions per subunit. {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-Y family. {ECO:0000305}.
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DR   EMBL; AF014938; AAC63530.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB14068.2; -; Genomic_DNA.
DR   RefSeq; NP_390033.2; NC_000964.3.
DR   RefSeq; WP_010886549.1; NC_000964.3.
DR   AlphaFoldDB; O31990; -.
DR   SMR; O31990; -.
DR   STRING; 224308.BSU21500; -.
DR   PaxDb; O31990; -.
DR   PRIDE; O31990; -.
DR   EnsemblBacteria; CAB14068; CAB14068; BSU_21500.
DR   GeneID; 939122; -.
DR   KEGG; bsu:BSU21500; -.
DR   PATRIC; fig|224308.43.peg.2242; -.
DR   eggNOG; COG0389; Bacteria.
DR   InParanoid; O31990; -.
DR   OMA; YRYEPHR; -.
DR   PhylomeDB; O31990; -.
DR   BioCyc; BSUB:BSU21500-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0042276; P:error-prone translesion synthesis; IBA:GO_Central.
DR   GO; GO:0009432; P:SOS response; IBA:GO_Central.
DR   Gene3D; 3.30.1490.100; -; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR036775; DNA_pol_Y-fam_lit_finger_sf.
DR   InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR   InterPro; IPR024728; PolY_HhH_motif.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR001126; UmuC.
DR   Pfam; PF00817; IMS; 1.
DR   Pfam; PF11799; IMS_C; 1.
DR   Pfam; PF11798; IMS_HHH; 1.
DR   SUPFAM; SSF100879; SSF100879; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS50173; UMUC; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; DNA-binding; Magnesium; Metal-binding;
KW   Nucleotidyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..416
FT                   /note="Putative UV-damage repair protein UvrX"
FT                   /id="PRO_0000382682"
FT   DOMAIN          12..196
FT                   /note="UmuC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00216"
FT   ACT_SITE        116
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00216"
FT   BINDING         16
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00216"
FT   BINDING         115
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00216"
SQ   SEQUENCE   416 AA;  46715 MW;  DD7E6FA85690EFC6 CRC64;
     MIDYSQFPRK NILCVDMKSF YASVSAVTMG LNPLTCYLAV VGNTDRQGSV VLAASPALKK
     DFGIKTGSRL FEIPEDPRIH IVNPQMKLFI RVSTEITKLF YRFVPEKCVH TYSIDESFLD
     AGKEDPEEMA KAIQSSMWRE FGLMCTVGIG DNMLLSKLAL DLESKKTKSG IARWRYEDVP
     NKLWKVRPLS KMWGIGGRME RNLNRMGIST IGQLAKFPLE LLEKKFGIMG NQLYYHAHGI
     DLSEIGAPLM QGQISFGKSQ ILLRDYTRSE EIKAVLLEIC EEVARRARTH NKVGRTISLG
     IGYSKDELGG GFHRSKTIDL PTSITMDIYR CCLMLFNKFY SGKTVRSVSV TLSNIEDDVN
     QQLSLFEVDN EKRRKLGFVM DGIRSKYGSK AILRAVSYTP AGTALQRAGL TGGHKS