ID   UVSE_ALKHC              Reviewed;         322 AA.
AC   Q9K9P8;
DT   06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=UV DNA damage endonuclease {ECO:0000255|HAMAP-Rule:MF_00606};
DE            Short=UV-endonuclease {ECO:0000255|HAMAP-Rule:MF_00606};
DE            Short=UVED {ECO:0000255|HAMAP-Rule:MF_00606};
DE            EC=3.-.-.- {ECO:0000255|HAMAP-Rule:MF_00606};
GN   Name=uvsE {ECO:0000255|HAMAP-Rule:MF_00606}; OrderedLocusNames=BH2597;
OS   Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344
OS   / JCM 9153 / C-125) (Bacillus halodurans).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX   NCBI_TaxID=272558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX   PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA   Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F.,
RA   Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
RT   "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans
RT   and genomic sequence comparison with Bacillus subtilis.";
RL   Nucleic Acids Res. 28:4317-4331(2000).
CC   -!- FUNCTION: Component in a DNA repair pathway. Removal of UV LIGHT
CC       damaged nucleotides. Recognizes pyrimidine dimers and cleave a
CC       phosphodiester bond immediately 5' to the lesion (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the uve1/UvsE family. {ECO:0000255|HAMAP-
CC       Rule:MF_00606}.
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DR   EMBL; BA000004; BAB06316.1; -; Genomic_DNA.
DR   PIR; E83974; E83974.
DR   RefSeq; WP_010898748.1; NC_002570.2.
DR   AlphaFoldDB; Q9K9P8; -.
DR   SMR; Q9K9P8; -.
DR   STRING; 272558.10175218; -.
DR   EnsemblBacteria; BAB06316; BAB06316; BAB06316.
DR   KEGG; bha:BH2597; -.
DR   eggNOG; COG4294; Bacteria.
DR   HOGENOM; CLU_017168_0_1_9; -.
DR   OMA; NIRFMRI; -.
DR   OrthoDB; 1036440at2; -.
DR   Proteomes; UP000001258; Chromosome.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR   GO; GO:0006290; P:pyrimidine dimer repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009411; P:response to UV; IEA:InterPro.
DR   HAMAP; MF_00606; UV_endonuclease; 1.
DR   InterPro; IPR004601; UvdE.
DR   InterPro; IPR023520; UvdE_bac.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   PANTHER; PTHR31290; PTHR31290; 1.
DR   Pfam; PF03851; UvdE; 1.
DR   SUPFAM; SSF51658; SSF51658; 1.
DR   TIGRFAMs; TIGR00629; uvde; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA excision; DNA repair; Endonuclease; Hydrolase; Nuclease;
KW   Reference proteome.
FT   CHAIN           1..322
FT                   /note="UV DNA damage endonuclease"
FT                   /id="PRO_0000215033"
SQ   SEQUENCE   322 AA;  36900 MW;  4B0DC9291CD1E7B4 CRC64;
     MRIQFGYVAM SMELANASPS KTMTATQFEK IEDHEAGLRK LERIAKTNLH NCLRLLKHNL
     AYQISFFRLS SKLVPLVNHP LTEGWKYELA IAEELQAVGE FASEHQMRID FHPDHFVVLN
     SEAKEITRRS LQTLLYHYKL LKGMEIDPRH RCVLHVGGKK KGVEAGLEQF IENTASIPKS
     LLSMIMLEND DKSYTIDDVL YLGEKLAIPV VLDIHHHDVL HRSKSLQETW QRIVATWEDS
     PLPVKIHLSS PLSGEDDPRH HDYINADRFI AFLHEIGADA VDHLHVMIEA KKKDLALFQL
     MKDLAEYDEI TVVSKSAVEF NP