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UVSE_BACAN
ID   UVSE_BACAN              Reviewed;         317 AA.
AC   Q81JV2; Q6HQF3; Q6KJS8;
DT   25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2003, sequence version 2.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=UV DNA damage endonuclease {ECO:0000255|HAMAP-Rule:MF_00606};
DE            Short=UV-endonuclease {ECO:0000255|HAMAP-Rule:MF_00606};
DE            Short=UVED {ECO:0000255|HAMAP-Rule:MF_00606};
DE            EC=3.-.-.- {ECO:0000255|HAMAP-Rule:MF_00606};
GN   Name=uvsE {ECO:0000255|HAMAP-Rule:MF_00606};
GN   OrderedLocusNames=BA_5592, GBAA_5592, BAS5196;
OS   Bacillus anthracis.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=1392;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ames / isolate Porton;
RX   PubMed=12721629; DOI=10.1038/nature01586;
RA   Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T.,
RA   Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R.,
RA   Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M.,
RA   Kolonay J.F., Beanan M.J., Dodson R.J., Brinkac L.M., Gwinn M.L.,
RA   DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C.,
RA   Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y.,
RA   Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M.,
RA   Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E.,
RA   White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M.,
RA   Hanna P.C., Kolstoe A.-B., Fraser C.M.;
RT   "The genome sequence of Bacillus anthracis Ames and comparison to closely
RT   related bacteria.";
RL   Nature 423:81-86(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ames ancestor;
RX   PubMed=18952800; DOI=10.1128/jb.01347-08;
RA   Ravel J., Jiang L., Stanley S.T., Wilson M.R., Decker R.S., Read T.D.,
RA   Worsham P., Keim P.S., Salzberg S.L., Fraser-Liggett C.M., Rasko D.A.;
RT   "The complete genome sequence of Bacillus anthracis Ames 'Ancestor'.";
RL   J. Bacteriol. 191:445-446(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Sterne;
RA   Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K.,
RA   Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R.,
RA   Richardson P., Rubin E., Tice H.;
RT   "Complete genome sequence of Bacillus anthracis Sterne.";
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component in a DNA repair pathway. Removal of UV LIGHT
CC       damaged nucleotides. Recognizes pyrimidine dimers and cleave a
CC       phosphodiester bond immediately 5' to the lesion (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the uve1/UvsE family. {ECO:0000255|HAMAP-
CC       Rule:MF_00606}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAP29234.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAT34738.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAT57485.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE016879; AAP29234.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE017334; AAT34738.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE017225; AAT57485.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_847748.1; NC_003997.3.
DR   RefSeq; WP_000605872.1; NZ_WXXJ01000038.1.
DR   AlphaFoldDB; Q81JV2; -.
DR   SMR; Q81JV2; -.
DR   STRING; 260799.BAS5196; -.
DR   DNASU; 1085290; -.
DR   EnsemblBacteria; AAP29234; AAP29234; BA_5592.
DR   EnsemblBacteria; AAT34738; AAT34738; GBAA_5592.
DR   GeneID; 45025177; -.
DR   KEGG; ban:BA_5592; -.
DR   KEGG; bar:GBAA_5592; -.
DR   KEGG; bat:BAS5196; -.
DR   PATRIC; fig|198094.11.peg.5550; -.
DR   eggNOG; COG4294; Bacteria.
DR   HOGENOM; CLU_017168_0_1_9; -.
DR   OMA; VFDAHHH; -.
DR   Proteomes; UP000000427; Chromosome.
DR   Proteomes; UP000000594; Chromosome.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR   GO; GO:0006290; P:pyrimidine dimer repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009411; P:response to UV; IEA:InterPro.
DR   HAMAP; MF_00606; UV_endonuclease; 1.
DR   InterPro; IPR004601; UvdE.
DR   InterPro; IPR023520; UvdE_bac.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   PANTHER; PTHR31290; PTHR31290; 1.
DR   Pfam; PF03851; UvdE; 1.
DR   SUPFAM; SSF51658; SSF51658; 1.
DR   TIGRFAMs; TIGR00629; uvde; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA excision; DNA repair; Endonuclease; Hydrolase; Nuclease;
KW   Reference proteome.
FT   CHAIN           1..317
FT                   /note="UV DNA damage endonuclease"
FT                   /id="PRO_0000215031"
FT   CONFLICT        192
FT                   /note="C -> Y (in Ref. 3; AAT57485)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   317 AA;  36818 MW;  1871FC903CEC485A CRC64;
     MIMRFGYVSH AMALWDCSPA KTITFTSFQK LSKQEREDKL YDVTKQNLEH TIRILHYNIA
     HEIPLYRLSS SIVPLATHPE VEFDYIGAFT PLWRKIGALI KEHNLRISFH PNQFTLFTSD
     KPHITTNAIT DMTYHYKVLD AIGIADSSYI NIHVGGAYGN KEKAIERFHE NIKKLPAHIK
     KQMTLENDDK TCTTAETLSI CQKEKIPFVF DYHHHMANLC EEPLEELLPA IFETWSHTNI
     VPKVHISSPK SKKEFRAHAE YIDLEFIKPF LHVAKKINHN FDIMIESKQK DLAMLQFIQE
     LSSIRGIKRI SSSTLQW
 
 
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