CAF5_SCHPO
ID CAF5_SCHPO Reviewed; 531 AA.
AC O94528;
DT 05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 124.
DE RecName: Full=Caffeine resistance protein 5;
GN Name=caf5; ORFNames=SPBC609.04;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=14758541; DOI=10.1007/s00438-003-0967-3;
RA Benko Z., Fenyvesvolgyi C., Pesti M., Sipiczki M.;
RT "The transcription factor Pap1/Caf3 plays a central role in the
RT determination of caffeine resistance in Schizosaccharomyces pombe.";
RL Mol. Genet. Genomics 271:161-170(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. CAR1 family.
CC {ECO:0000305}.
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DR EMBL; CU329671; CAA22833.1; -; Genomic_DNA.
DR PIR; T40575; T40575.
DR RefSeq; NP_596314.1; NM_001022236.2.
DR AlphaFoldDB; O94528; -.
DR BioGRID; 277631; 11.
DR STRING; 4896.SPBC609.04.1; -.
DR TCDB; 2.A.1.2.35; the major facilitator superfamily (mfs).
DR iPTMnet; O94528; -.
DR PaxDb; O94528; -.
DR PRIDE; O94528; -.
DR EnsemblFungi; SPBC609.04.1; SPBC609.04.1:pep; SPBC609.04.
DR GeneID; 2541116; -.
DR KEGG; spo:SPBC609.04; -.
DR PomBase; SPBC609.04; caf5.
DR VEuPathDB; FungiDB:SPBC609.04; -.
DR eggNOG; KOG0255; Eukaryota.
DR HOGENOM; CLU_008455_11_1_1; -.
DR InParanoid; O94528; -.
DR OMA; WFESFAI; -.
DR PhylomeDB; O94528; -.
DR PRO; PR:O94528; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005794; C:Golgi apparatus; HDA:PomBase.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISO:PomBase.
DR GO; GO:0015244; F:fluconazole transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0000297; F:spermine transmembrane transporter activity; ISO:PomBase.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:1903710; P:spermine transmembrane transport; ISO:PomBase.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..531
FT /note="Caffeine resistance protein 5"
FT /id="PRO_0000173432"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 158..178
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 325..345
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 358..378
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 398..418
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 424..444
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 495..515
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 531 AA; 59141 MW; 68208F47603206C7 CRC64;
MGFLRETVFG ELVEYVSHNS NDNDLEKLRV WKDISKVDSN DSCSSESGDL KIHEVNSEGH
IIVRWDDAND PENPLNWPLW AKLVVTFDIC FLTFAVYVGS AIFTPGISEM QETMHVGTVP
VVLGLTLFVL GYAIGPLILS PLSEIPQVGR QKIYVLSLLV FVCLQIPTAL GSSLGVLLPM
RFLAGFFGSP ALATGGATLA DIWQPWLLPY FMCFWAIGAI GGPVLGPLLG GAMVVAESWR
WQFWLLMMIS GFALIVIFFF MPETSEWHIL YKRAKRFRKI TGNENYRTEA ELASSHLSVA
QLAKETIIRP IILSISEPIV LSLNIYIGLI YSILYLWFEA FPILFTSVYH FTIIENGLVY
LGILVGALIT LACYFVFLYK VMIPAFMASG GDFAPEGVLV ISFPATFFIP ICLFWFGWSG
RESVHWIVPI VSTLFYASGA FLMFQSMFQY LAASYPKYVA SVFAGNDLFR SAMAASFPLF
ARAMFNNTGP SYAPVAWGST ILGIVACLMI PIPFVLHKWG LKLRSRSKYA S
