ID   UVSE_BACCR              Reviewed;         317 AA.
AC   Q9L4F0; Q9L4E9;
DT   06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=UV DNA damage endonuclease {ECO:0000255|HAMAP-Rule:MF_00606};
DE            Short=UV-endonuclease {ECO:0000255|HAMAP-Rule:MF_00606};
DE            Short=UVED {ECO:0000255|HAMAP-Rule:MF_00606};
DE            EC=3.-.-.- {ECO:0000255|HAMAP-Rule:MF_00606};
GN   Name=uvsE {ECO:0000255|HAMAP-Rule:MF_00606}; OrderedLocusNames=BC_5347;
OS   Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC
OS   15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=226900;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10589720; DOI=10.1099/00221287-145-11-3129;
RA   Oekstad O.A., Gominet M., Purnelle B., Rose M., Lereclus D., Kolstoe A.-B.;
RT   "Sequence analysis of three Bacillus cereus loci carrying PIcR-regulated
RT   genes encoding degradative enzymes and enterotoxin.";
RL   Microbiology 145:3129-3138(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373
RC   / NCTC 2599 / NRRL B-3711;
RX   PubMed=12721630; DOI=10.1038/nature01582;
RA   Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V.,
RA   Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M.,
RA   Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G.,
RA   Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., Kyrpides N.C.;
RT   "Genome sequence of Bacillus cereus and comparative analysis with Bacillus
RT   anthracis.";
RL   Nature 423:87-91(2003).
CC   -!- FUNCTION: Component in a DNA repair pathway. Removal of UV LIGHT
CC       damaged nucleotides. Recognizes pyrimidine dimers and cleave a
CC       phosphodiester bond immediately 5' to the lesion (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the uve1/UvsE family. {ECO:0000255|HAMAP-
CC       Rule:MF_00606}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAB69814.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AJ243712; CAB69813.1; -; Genomic_DNA.
DR   EMBL; AJ243712; CAB69814.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE016877; AAP12210.1; -; Genomic_DNA.
DR   RefSeq; NP_835009.1; NC_004722.1.
DR   RefSeq; WP_011110499.1; NZ_CP034551.1.
DR   AlphaFoldDB; Q9L4F0; -.
DR   SMR; Q9L4F0; -.
DR   STRING; 226900.BC_5347; -.
DR   EnsemblBacteria; AAP12210; AAP12210; BC_5347.
DR   KEGG; bce:BC5347; -.
DR   PATRIC; fig|226900.8.peg.5521; -.
DR   HOGENOM; CLU_017168_0_1_9; -.
DR   OMA; VFDAHHH; -.
DR   Proteomes; UP000001417; Chromosome.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR   GO; GO:0006290; P:pyrimidine dimer repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009411; P:response to UV; IEA:InterPro.
DR   HAMAP; MF_00606; UV_endonuclease; 1.
DR   InterPro; IPR004601; UvdE.
DR   InterPro; IPR023520; UvdE_bac.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   PANTHER; PTHR31290; PTHR31290; 1.
DR   Pfam; PF03851; UvdE; 1.
DR   SUPFAM; SSF51658; SSF51658; 1.
DR   TIGRFAMs; TIGR00629; uvde; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA excision; DNA repair; Endonuclease; Hydrolase; Nuclease;
KW   Reference proteome.
FT   CHAIN           1..317
FT                   /note="UV DNA damage endonuclease"
FT                   /id="PRO_0000215032"
SQ   SEQUENCE   317 AA;  36991 MW;  A6AC35F5800A22C3 CRC64;
     MLIRFGYVSH AMALWDCSPA KTMTFTSFKK LSKQEREDKL YHVIRQNLEH TIRILHYNIA
     HEIPLYRLSS SIVPLATHPE VEFDYIGVFT PLWRKIGALI KEHNLRISFH PNQFTLFTSD
     KPHITTNAIT DMTYHYKILD AIGIADSSYI NIHVGGAYGN KEKAIERFHE NIKKLPTHIK
     KQMTLENDDK TYTTAETLSI CQKENIPFVF DYHHHMANLC EEPLEELLPA IFETWSHTNI
     SPKVHISSPR SEKEFRAHAE YIDLEFIKPF LHIAKKHNHN FDIMIESKQK DLALFQLIDE
     LSAIRGIKRI SGAMLQW