UVSE_BACHK
ID UVSE_BACHK Reviewed; 317 AA.
AC Q6HAT6;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=UV DNA damage endonuclease {ECO:0000255|HAMAP-Rule:MF_00606};
DE Short=UV-endonuclease {ECO:0000255|HAMAP-Rule:MF_00606};
DE Short=UVED {ECO:0000255|HAMAP-Rule:MF_00606};
DE EC=3.-.-.- {ECO:0000255|HAMAP-Rule:MF_00606};
GN Name=uvsE {ECO:0000255|HAMAP-Rule:MF_00606}; OrderedLocusNames=BT9727_5031;
OS Bacillus thuringiensis subsp. konkukian (strain 97-27).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=281309;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=97-27;
RX PubMed=16621833; DOI=10.1128/jb.188.9.3382-3390.2006;
RA Han C.S., Xie G., Challacombe J.F., Altherr M.R., Bhotika S.S., Bruce D.,
RA Campbell C.S., Campbell M.L., Chen J., Chertkov O., Cleland C.,
RA Dimitrijevic M., Doggett N.A., Fawcett J.J., Glavina T., Goodwin L.A.,
RA Hill K.K., Hitchcock P., Jackson P.J., Keim P., Kewalramani A.R.,
RA Longmire J., Lucas S., Malfatti S., McMurry K., Meincke L.J., Misra M.,
RA Moseman B.L., Mundt M., Munk A.C., Okinaka R.T., Parson-Quintana B.,
RA Reilly L.P., Richardson P., Robinson D.L., Rubin E., Saunders E., Tapia R.,
RA Tesmer J.G., Thayer N., Thompson L.S., Tice H., Ticknor L.O., Wills P.L.,
RA Brettin T.S., Gilna P.;
RT "Pathogenomic sequence analysis of Bacillus cereus and Bacillus
RT thuringiensis isolates closely related to Bacillus anthracis.";
RL J. Bacteriol. 188:3382-3390(2006).
CC -!- FUNCTION: Component in a DNA repair pathway. Removal of UV LIGHT
CC damaged nucleotides. Recognizes pyrimidine dimers and cleave a
CC phosphodiester bond immediately 5' to the lesion (By similarity).
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the uve1/UvsE family. {ECO:0000255|HAMAP-
CC Rule:MF_00606}.
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DR EMBL; AE017355; AAT63971.1; -; Genomic_DNA.
DR RefSeq; WP_000605880.1; NC_005957.1.
DR RefSeq; YP_039340.1; NC_005957.1.
DR AlphaFoldDB; Q6HAT6; -.
DR SMR; Q6HAT6; -.
DR EnsemblBacteria; AAT63971; AAT63971; BT9727_5031.
DR KEGG; btk:BT9727_5031; -.
DR PATRIC; fig|281309.8.peg.5351; -.
DR HOGENOM; CLU_017168_0_1_9; -.
DR OMA; VFDAHHH; -.
DR Proteomes; UP000001301; Chromosome.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR GO; GO:0006290; P:pyrimidine dimer repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009411; P:response to UV; IEA:InterPro.
DR HAMAP; MF_00606; UV_endonuclease; 1.
DR InterPro; IPR004601; UvdE.
DR InterPro; IPR023520; UvdE_bac.
DR InterPro; IPR036237; Xyl_isomerase-like_sf.
DR PANTHER; PTHR31290; PTHR31290; 1.
DR Pfam; PF03851; UvdE; 1.
DR SUPFAM; SSF51658; SSF51658; 1.
DR TIGRFAMs; TIGR00629; uvde; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA excision; DNA repair; Endonuclease; Hydrolase; Nuclease.
FT CHAIN 1..317
FT /note="UV DNA damage endonuclease"
FT /id="PRO_1000025882"
SQ SEQUENCE 317 AA; 36879 MW; 1870FDD0DCE14FF0 CRC64;
MIMRFGYVSH AMALWDCSPA KTITFTSFQK LSKQEREDKL YDVTKQNLEH TLRILHYNIA
HEIPLYRLSS SIVPLATHPE VEFDYIGAFT PLWRKIGALI KEHNLRISFH PNQFTLFTSD
KPHITTNAIT DMTYHYKVLD AIGIADSSYI NIHVGGAYGN KEKAIERFHE NIKKLPAHIK
KQMTLENDDK TYTTAETLSI CQKEKIPFVF DYHHHMANLC EEPLEELLPA IFETWSHTNI
VPKVHISSPK SKKEFRAHAE YIDLEFIKPF LHVAKKINHN FDIMIESKQK DLAMLQFIQE
LSSIRGIKRI SSSTLQW