ID   UVSE_BACMK              Reviewed;         317 AA.
AC   A9VSE5;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=UV DNA damage endonuclease {ECO:0000255|HAMAP-Rule:MF_00606};
DE            Short=UV-endonuclease {ECO:0000255|HAMAP-Rule:MF_00606};
DE            Short=UVED {ECO:0000255|HAMAP-Rule:MF_00606};
DE            EC=3.-.-.- {ECO:0000255|HAMAP-Rule:MF_00606};
GN   Name=uvsE {ECO:0000255|HAMAP-Rule:MF_00606};
GN   OrderedLocusNames=BcerKBAB4_5145;
OS   Bacillus mycoides (strain KBAB4) (Bacillus weihenstephanensis).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=315730;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KBAB4;
RX   PubMed=17434157; DOI=10.1016/j.cbi.2007.03.003;
RA   Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C.,
RA   Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V.,
RA   Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J.,
RA   Ehrlich S.D., Sorokin A.;
RT   "Extending the Bacillus cereus group genomics to putative food-borne
RT   pathogens of different toxicity.";
RL   Chem. Biol. Interact. 171:236-249(2008).
CC   -!- FUNCTION: Component in a DNA repair pathway. Removal of UV LIGHT
CC       damaged nucleotides. Recognizes pyrimidine dimers and cleave a
CC       phosphodiester bond immediately 5' to the lesion (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the uve1/UvsE family. {ECO:0000255|HAMAP-
CC       Rule:MF_00606}.
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DR   EMBL; CP000903; ABY46291.1; -; Genomic_DNA.
DR   RefSeq; WP_002143890.1; NC_010184.1.
DR   AlphaFoldDB; A9VSE5; -.
DR   SMR; A9VSE5; -.
DR   STRING; 315730.BcerKBAB4_5145; -.
DR   EnsemblBacteria; ABY46291; ABY46291; BcerKBAB4_5145.
DR   KEGG; bwe:BcerKBAB4_5145; -.
DR   eggNOG; COG4294; Bacteria.
DR   HOGENOM; CLU_017168_0_1_9; -.
DR   OMA; VFDAHHH; -.
DR   Proteomes; UP000002154; Chromosome.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR   GO; GO:0006290; P:pyrimidine dimer repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009411; P:response to UV; IEA:InterPro.
DR   HAMAP; MF_00606; UV_endonuclease; 1.
DR   InterPro; IPR004601; UvdE.
DR   InterPro; IPR023520; UvdE_bac.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   PANTHER; PTHR31290; PTHR31290; 1.
DR   Pfam; PF03851; UvdE; 1.
DR   SUPFAM; SSF51658; SSF51658; 1.
DR   TIGRFAMs; TIGR00629; uvde; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA excision; DNA repair; Endonuclease; Hydrolase; Nuclease.
FT   CHAIN           1..317
FT                   /note="UV DNA damage endonuclease"
FT                   /id="PRO_1000130232"
SQ   SEQUENCE   317 AA;  37142 MW;  C17FF0CF21D90CAF CRC64;
     MIIRFGYVSH ATALWDCSPA KTMTFTSWKK LKKQEREDKL YNVTLQNLEH TIRILHYNIA
     HEIPLYRLSS SIVPLATHPE VEFDYIQIFA PLWRKIGALI QEHNLRVSFH PNQFTLFTSD
     KPHITTNAIT DMTYHYNVLN AMGIADSSYI NIHVGGAYGN KEKAIERFHE NIQKLPYHIK
     RQMTLENDDK TYTTSETLAI CQKEKIPFVF DYHHHIANLC NEPLEELLPM IFKTWSHTNV
     LPKVHISSPR SEKEFRAHAD YIDLEFIKPF LHITKKINHN FDIMIESKQK DLAMLQLICE
     LSSIRGIKRI NSATLQW