ID   UVSE_BACP2              Reviewed;         320 AA.
AC   A8FIG1;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=UV DNA damage endonuclease {ECO:0000255|HAMAP-Rule:MF_00606};
DE            Short=UV-endonuclease {ECO:0000255|HAMAP-Rule:MF_00606};
DE            Short=UVED {ECO:0000255|HAMAP-Rule:MF_00606};
DE            EC=3.-.-.- {ECO:0000255|HAMAP-Rule:MF_00606};
GN   Name=uvsE {ECO:0000255|HAMAP-Rule:MF_00606}; OrderedLocusNames=BPUM_3376;
OS   Bacillus pumilus (strain SAFR-032).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=315750;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SAFR-032;
RX   PubMed=17895969; DOI=10.1371/journal.pone.0000928;
RA   Gioia J., Yerrapragada S., Qin X., Jiang H., Igboeli O.C., Muzny D.,
RA   Dugan-Rocha S., Ding Y., Hawes A., Liu W., Perez L., Kovar C., Dinh H.,
RA   Lee S., Nazareth L., Blyth P., Holder M., Buhay C., Tirumalai M.R., Liu Y.,
RA   Dasgupta I., Bokhetache L., Fujita M., Karouia F., Eswara Moorthy P.,
RA   Siefert J., Uzman A., Buzumbo P., Verma A., Zwiya H., McWilliams B.D.,
RA   Olowu A., Clinkenbeard K.D., Newcombe D., Golebiewski L., Petrosino J.F.,
RA   Nicholson W.L., Fox G.E., Venkateswaran K., Highlander S.K.,
RA   Weinstock G.M.;
RT   "Paradoxical DNA repair and peroxide resistance gene conservation in
RT   Bacillus pumilus SAFR-032.";
RL   PLoS ONE 2:E928-E928(2007).
CC   -!- FUNCTION: Component in a DNA repair pathway. Removal of UV LIGHT
CC       damaged nucleotides. Recognizes pyrimidine dimers and cleave a
CC       phosphodiester bond immediately 5' to the lesion (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the uve1/UvsE family. {ECO:0000255|HAMAP-
CC       Rule:MF_00606}.
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DR   EMBL; CP000813; ABV64028.1; -; Genomic_DNA.
DR   RefSeq; WP_012011587.1; NZ_VEIA01000001.1.
DR   AlphaFoldDB; A8FIG1; -.
DR   SMR; A8FIG1; -.
DR   STRING; 315750.BPUM_3376; -.
DR   EnsemblBacteria; ABV64028; ABV64028; BPUM_3376.
DR   KEGG; bpu:BPUM_3376; -.
DR   eggNOG; COG4294; Bacteria.
DR   HOGENOM; CLU_017168_0_1_9; -.
DR   OMA; VFDAHHH; -.
DR   OrthoDB; 1036440at2; -.
DR   Proteomes; UP000001355; Chromosome.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR   GO; GO:0006290; P:pyrimidine dimer repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009411; P:response to UV; IEA:InterPro.
DR   HAMAP; MF_00606; UV_endonuclease; 1.
DR   InterPro; IPR004601; UvdE.
DR   InterPro; IPR023520; UvdE_bac.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   PANTHER; PTHR31290; PTHR31290; 1.
DR   Pfam; PF03851; UvdE; 1.
DR   SUPFAM; SSF51658; SSF51658; 1.
DR   TIGRFAMs; TIGR00629; uvde; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA excision; DNA repair; Endonuclease; Hydrolase; Nuclease;
KW   Reference proteome.
FT   CHAIN           1..320
FT                   /note="UV DNA damage endonuclease"
FT                   /id="PRO_1000061276"
SQ   SEQUENCE   320 AA;  36456 MW;  F59E7CE104B9EB54 CRC64;
     MRYRFGYVSN AVTLWEASPA KSLTFARYSK LSKEEGKEAL LRTTKANLVN TLRTLYFAIS
     HDIPLYRFSS SIVPLATHPE VRWDFVTPFQ KEFLEIGDLV KRHGLRVSFH PNQFTLFTSP
     KPSITENAVI DMTYHYQMLE AMKLEKEGYM NIHVGGAYGD KDSALQRFDE NIKQLPAHIK
     ARMTLENDDK TYTSLETLGV CEKHGIPFVF DYHHHVANKD DNAALEDILP RMFDTWTSTG
     IPPKIHLSSP KSEKAIRSHA DGVDMSFVLP LFHALKPCGR DVDFMIEAKL KDQALLRLVE
     ELSAIRGNKR VGGGTIEWKP