UVSE_BACSU
ID UVSE_BACSU Reviewed; 320 AA.
AC P45864;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=UV DNA damage endonuclease {ECO:0000255|HAMAP-Rule:MF_00606};
DE Short=UV-endonuclease {ECO:0000255|HAMAP-Rule:MF_00606};
DE Short=UVED {ECO:0000255|HAMAP-Rule:MF_00606};
DE EC=3.-.-.- {ECO:0000255|HAMAP-Rule:MF_00606};
GN Name=uvsE {ECO:0000255|HAMAP-Rule:MF_00606}; Synonyms=ywjD;
GN OrderedLocusNames=BSU37200;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9353933; DOI=10.1099/00221287-143-10-3313;
RA Presecan E., Moszer I., Boursier L., Cruz Ramos H., De La Fuente V.,
RA Hullo M.-F., Lelong C., Schleich S., Sekowska A., Song B.H., Villani G.,
RA Kunst F., Danchin A., Glaser P.;
RT "The Bacillus subtilis genome from gerBC (311 degrees) to licR (334
RT degrees).";
RL Microbiology 143:3313-3328(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP FUNCTION.
RC STRAIN=972;
RX PubMed=8614629; DOI=10.1093/nar/24.7.1267;
RA Takao M., Yonemasu R., Yamamoto K., Yasui A.;
RT "Characterization of a UV endonuclease gene from the fission yeast
RT Schizosaccharomyces pombe and its bacterial homolog.";
RL Nucleic Acids Res. 24:1267-1271(1996).
CC -!- FUNCTION: Component in a DNA repair pathway. Removal of UV LIGHT
CC damaged nucleotides. Recognizes pyrimidine dimers and cleave a
CC phosphodiester bond immediately 5' to the lesion (By similarity).
CC {ECO:0000250, ECO:0000269|PubMed:8614629}.
CC -!- SIMILARITY: Belongs to the uve1/UvsE family. {ECO:0000255|HAMAP-
CC Rule:MF_00606}.
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DR EMBL; Z49782; CAA89865.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB15748.1; -; Genomic_DNA.
DR PIR; S55418; S55418.
DR RefSeq; NP_391601.1; NC_000964.3.
DR RefSeq; WP_003227599.1; NZ_JNCM01000034.1.
DR AlphaFoldDB; P45864; -.
DR SMR; P45864; -.
DR STRING; 224308.BSU37200; -.
DR PaxDb; P45864; -.
DR PRIDE; P45864; -.
DR EnsemblBacteria; CAB15748; CAB15748; BSU_37200.
DR GeneID; 938195; -.
DR KEGG; bsu:BSU37200; -.
DR PATRIC; fig|224308.179.peg.4030; -.
DR eggNOG; COG4294; Bacteria.
DR InParanoid; P45864; -.
DR OMA; VFDAHHH; -.
DR BioCyc; BSUB:BSU37200-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR GO; GO:0006290; P:pyrimidine dimer repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009411; P:response to UV; IEA:InterPro.
DR HAMAP; MF_00606; UV_endonuclease; 1.
DR InterPro; IPR004601; UvdE.
DR InterPro; IPR023520; UvdE_bac.
DR InterPro; IPR036237; Xyl_isomerase-like_sf.
DR PANTHER; PTHR31290; PTHR31290; 1.
DR Pfam; PF03851; UvdE; 1.
DR SUPFAM; SSF51658; SSF51658; 1.
DR TIGRFAMs; TIGR00629; uvde; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA excision; DNA repair; Endonuclease; Hydrolase; Nuclease;
KW Reference proteome.
FT CHAIN 1..320
FT /note="UV DNA damage endonuclease"
FT /id="PRO_0000215034"
SQ SEQUENCE 320 AA; 36896 MW; 2FD35A710648E002 CRC64;
MIFRFGFVSN AMSLWDASPA KTLTFARYSK LSKTERKEAL LTVTKANLRN TMRTLHYIIG
HGIPLYRFSS SIVPLATHPD VMWDFVTPFQ KEFREIGELV KTHQLRTSFH PNQFTLFTSP
KESVTKNAVT DMAYHYRMLE AMGIADRSVI NIHIGGAYGN KDTATAQFHQ NIKQLPQEIK
ERMTLENDDK TYTTEETLQV CEQEDVPFVF DFHHFYANPD DHADLNVALP RMIKTWERIG
LQPKVHLSSP KSEQAIRSHA DYVDANFLLP LLERFRQWGT NIDFMIEAKQ KDKALLRLMD
ELSSIRGVKR IGGGALQWKS
