ID   UVSE_CLOPE              Reviewed;         412 AA.
AC   Q8XIP3;
DT   06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=UV DNA damage endonuclease {ECO:0000255|HAMAP-Rule:MF_00606};
DE            Short=UV-endonuclease {ECO:0000255|HAMAP-Rule:MF_00606};
DE            Short=UVED {ECO:0000255|HAMAP-Rule:MF_00606};
DE            EC=3.-.-.- {ECO:0000255|HAMAP-Rule:MF_00606};
GN   Name=uvsE {ECO:0000255|HAMAP-Rule:MF_00606}; OrderedLocusNames=CPE2072;
OS   Clostridium perfringens (strain 13 / Type A).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=195102;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=13 / Type A;
RX   PubMed=11792842; DOI=10.1073/pnas.022493799;
RA   Shimizu T., Ohtani K., Hirakawa H., Ohshima K., Yamashita A., Shiba T.,
RA   Ogasawara N., Hattori M., Kuhara S., Hayashi H.;
RT   "Complete genome sequence of Clostridium perfringens, an anaerobic flesh-
RT   eater.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:996-1001(2002).
CC   -!- FUNCTION: Component in a DNA repair pathway. Removal of UV LIGHT
CC       damaged nucleotides. Recognizes pyrimidine dimers and cleave a
CC       phosphodiester bond immediately 5' to the lesion (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the uve1/UvsE family. {ECO:0000255|HAMAP-
CC       Rule:MF_00606}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BA000016; BAB81778.1; -; Genomic_DNA.
DR   RefSeq; WP_011010747.1; NC_003366.1.
DR   AlphaFoldDB; Q8XIP3; -.
DR   SMR; Q8XIP3; -.
DR   STRING; 195102.gene:10491342; -.
DR   EnsemblBacteria; BAB81778; BAB81778; BAB81778.
DR   KEGG; cpe:CPE2072; -.
DR   HOGENOM; CLU_017168_0_0_9; -.
DR   OMA; MKIGYAC; -.
DR   Proteomes; UP000000818; Chromosome.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR   GO; GO:0006290; P:pyrimidine dimer repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009411; P:response to UV; IEA:InterPro.
DR   HAMAP; MF_00606; UV_endonuclease; 1.
DR   InterPro; IPR004601; UvdE.
DR   InterPro; IPR023520; UvdE_bac.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   PANTHER; PTHR31290; PTHR31290; 1.
DR   Pfam; PF03851; UvdE; 1.
DR   SUPFAM; SSF51658; SSF51658; 1.
DR   TIGRFAMs; TIGR00629; uvde; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA excision; DNA repair; Endonuclease; Hydrolase; Nuclease;
KW   Reference proteome.
FT   CHAIN           1..412
FT                   /note="UV DNA damage endonuclease"
FT                   /id="PRO_0000215035"
SQ   SEQUENCE   412 AA;  48463 MW;  FE9DE0BC20E42672 CRC64;
     MKIGYACTPI TTNARTNRRI LLKDFSKDKF LSITKQNLDD LQKILEWNIK NNIYLFRIGS
     DIIPLGSHEI NNISWQKEFK DKLETIGTFI KNNKIRVSMH PGQYTVINTP KEDVLYKSIK
     DIEYHCEFLD SLKVDYKNKI ILHIGGVYGD KKLAKENFLK GFKKLSDSSK KRLVIENDER
     NFSLDDVLDI SSKLNIPVIF DNLHNICYGD NSYSLKEIYS LVIKTWNKEL DGNMKVHYSE
     QDIFKKKGSH SPSISINSFL EYYEEIKEFS PDIMLEVKDK DISAIKCINS LKEINKTLNS
     KAYREEIENY KLLLLQHDKD FQKKLNSFSK DLIEFYNYLD KLLLSPKDII GFKYSLELAF
     NILKDRISNR ESLYFKKLIN EKEYEKAKVY LTKLVKKIEF PPKELSYYIS QS