ID   UVSE_DEIRA              Reviewed;         305 AA.
AC   Q9RTE6; Q9S0M9;
DT   06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2002, sequence version 2.
DT   25-MAY-2022, entry version 112.
DE   RecName: Full=UV DNA damage endonuclease;
DE            Short=UV-endonuclease;
DE            Short=UVED;
DE            EC=3.-.-.-;
DE   AltName: Full=Endonuclease beta;
GN   Name=uvsE; OrderedLocusNames=DR_1819;
OS   Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG
OS   4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422).
OC   Bacteria; Deinococcus-Thermus; Deinococci; Deinococcales; Deinococcaceae;
OC   Deinococcus.
OX   NCBI_TaxID=243230;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=KR1;
RA   Kitayama S., Kikuchi M., Funayama T., Narumi I., Watanabe H.;
RT   "Cloning of structural gene of an alternative incision enzyme for DNA
RT   damage in Deinococcus radiodurans.";
RL   Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC   9279 / R1 / VKM B-1422;
RX   PubMed=10567266; DOI=10.1126/science.286.5444.1571;
RA   White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D.,
RA   Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L.,
RA   Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M.,
RA   Vamathevan J.J., Lam P., McDonald L.A., Utterback T.R., Zalewski C.,
RA   Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D.,
RA   Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C.,
RA   Fraser C.M.;
RT   "Genome sequence of the radioresistant bacterium Deinococcus radiodurans
RT   R1.";
RL   Science 286:1571-1577(1999).
RN   [3]
RP   FUNCTION.
RC   STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC   9279 / R1 / VKM B-1422;
RX   PubMed=11807060; DOI=10.1128/jb.184.4.1003-1009.2002;
RA   Earl A.M., Rankin S.K., Kim K.-P., Lamendola O.N., Battista J.R.;
RT   "Genetic evidence that the uvsE gene product of Deinococcus radiodurans R1
RT   is a UV damage endonuclease.";
RL   J. Bacteriol. 184:1003-1009(2002).
RN   [4]
RP   CHARACTERIZATION.
RX   PubMed=3838572; DOI=10.1016/0167-8817(85)90018-5;
RA   Evans D.M., Moseley B.E.;
RT   "Identification and initial characterisation of a pyrimidine dimer UV
RT   endonuclease (UV endonuclease beta) from Deinococcus radiodurans; a DNA-
RT   repair enzyme that requires manganese ions.";
RL   Mutat. Res. 145:119-128(1985).
CC   -!- FUNCTION: Component in a DNA repair pathway. Removal of UV LIGHT
CC       damaged nucleotides. Recognizes pyrimidine dimers and cleave a
CC       phosphodiester bond immediately 5' to the lesion.
CC       {ECO:0000269|PubMed:11807060}.
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC   -!- SIMILARITY: Belongs to the uve1/UvsE family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF11370.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AB033747; BAA85759.1; -; Genomic_DNA.
DR   EMBL; AE000513; AAF11370.1; ALT_INIT; Genomic_DNA.
DR   PIR; C75350; C75350.
DR   RefSeq; NP_295542.1; NC_001263.1.
DR   RefSeq; WP_034350019.1; NC_001263.1.
DR   AlphaFoldDB; Q9RTE6; -.
DR   SMR; Q9RTE6; -.
DR   STRING; 243230.DR_1819; -.
DR   EnsemblBacteria; AAF11370; AAF11370; DR_1819.
DR   KEGG; dra:DR_1819; -.
DR   PATRIC; fig|243230.17.peg.2031; -.
DR   eggNOG; COG4294; Bacteria.
DR   HOGENOM; CLU_017168_0_2_0; -.
DR   InParanoid; Q9RTE6; -.
DR   OMA; VFDAHHH; -.
DR   OrthoDB; 1036440at2; -.
DR   Proteomes; UP000002524; Chromosome I.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR   GO; GO:0006290; P:pyrimidine dimer repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009411; P:response to UV; IEA:InterPro.
DR   HAMAP; MF_00606; UV_endonuclease; 1.
DR   InterPro; IPR004601; UvdE.
DR   InterPro; IPR023520; UvdE_bac.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   PANTHER; PTHR31290; PTHR31290; 1.
DR   Pfam; PF03851; UvdE; 1.
DR   SUPFAM; SSF51658; SSF51658; 1.
PE   1: Evidence at protein level;
KW   DNA damage; DNA excision; DNA repair; Endonuclease; Hydrolase; Manganese;
KW   Nuclease; Reference proteome.
FT   CHAIN           1..305
FT                   /note="UV DNA damage endonuclease"
FT                   /id="PRO_0000215036"
SQ   SEQUENCE   305 AA;  33592 MW;  B94D333243E2FEA4 CRC64;
     MTSACEAVPQ LGLVCLTVGP EVRFRTVTLS RYRALSPAER EAKLLDLYSS NIKTLRGAAD
     YCAAHDIRLY RLSSSLFPML DLAGDDTGAA VLTHLAPQLL EAGHAFTDAG VRLLMHPEQF
     IVLNSDRPEV RESSVRAMSA HARVMDGLGL ARTPWNLLLL HGGKGGRGAE LAALIPDLPD
     PVRLRLGLEN DERAYSPAEL LPICEATGTP LVFDAHHHVV HDKLPDQEDP SVREWVLRAR
     ATWQPPEWQV VHLSNGIEGP QDRRHSHLIA DFPSAYADVP WIEVEAKGKE EAIAALRLMA
     PFKKD