UVSE_NOSS1
ID UVSE_NOSS1 Reviewed; 322 AA.
AC Q8YXF0;
DT 06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=UV DNA damage endonuclease {ECO:0000255|HAMAP-Rule:MF_00606};
DE Short=UV-endonuclease {ECO:0000255|HAMAP-Rule:MF_00606};
DE Short=UVED {ECO:0000255|HAMAP-Rule:MF_00606};
DE EC=3.-.-.- {ECO:0000255|HAMAP-Rule:MF_00606};
GN Name=uvsE {ECO:0000255|HAMAP-Rule:MF_00606}; OrderedLocusNames=alr1263;
OS Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576).
OC Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
OX NCBI_TaxID=103690;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 7120 / SAG 25.82 / UTEX 2576;
RX PubMed=11759840; DOI=10.1093/dnares/8.5.205;
RA Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A.,
RA Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M.,
RA Takazawa M., Yamada M., Yasuda M., Tabata S.;
RT "Complete genomic sequence of the filamentous nitrogen-fixing
RT cyanobacterium Anabaena sp. strain PCC 7120.";
RL DNA Res. 8:205-213(2001).
CC -!- FUNCTION: Component in a DNA repair pathway. Removal of UV LIGHT
CC damaged nucleotides. Recognizes pyrimidine dimers and cleave a
CC phosphodiester bond immediately 5' to the lesion (By similarity).
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the uve1/UvsE family. {ECO:0000255|HAMAP-
CC Rule:MF_00606}.
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DR EMBL; BA000019; BAB73220.1; -; Genomic_DNA.
DR PIR; AD1964; AD1964.
DR AlphaFoldDB; Q8YXF0; -.
DR SMR; Q8YXF0; -.
DR STRING; 103690.17130610; -.
DR EnsemblBacteria; BAB73220; BAB73220; BAB73220.
DR KEGG; ana:alr1263; -.
DR eggNOG; COG4294; Bacteria.
DR OMA; VFDAHHH; -.
DR Proteomes; UP000002483; Chromosome.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR GO; GO:0006290; P:pyrimidine dimer repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009411; P:response to UV; IEA:InterPro.
DR HAMAP; MF_00606; UV_endonuclease; 1.
DR InterPro; IPR004601; UvdE.
DR InterPro; IPR023520; UvdE_bac.
DR InterPro; IPR036237; Xyl_isomerase-like_sf.
DR PANTHER; PTHR31290; PTHR31290; 1.
DR Pfam; PF03851; UvdE; 1.
DR SUPFAM; SSF51658; SSF51658; 1.
DR TIGRFAMs; TIGR00629; uvde; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA excision; DNA repair; Endonuclease; Hydrolase; Nuclease;
KW Reference proteome.
FT CHAIN 1..322
FT /note="UV DNA damage endonuclease"
FT /id="PRO_0000215030"
SQ SEQUENCE 322 AA; 37227 MW; D6BD6B78D5541B32 CRC64;
MVTIDNSMTA TQLNDLPQTA QLRKNAQPEL GLVCITFDKK VRFRTMTRTR YLKLSLAQRE
SSLREIYLHN LQCLHDALTF CQENNLRLYR ISSALFPLSD MEDQIGSNIL EEISTDLGKI
GERSQALNIR MVLHPDQYVV LSSDSPEIVQ TSIKILERHA RTFDLLGLPR SPWSLMNIHG
GKSQRSEQLI KVISNLPENI KSRLTLENDE YAYSTEEIFN VCQKAQIPMV FDAHHQICHE
NLDSYDHPSV AAMFYAARET WTNPEWQLVH ISNGEQAFND RKHSNLITNM PNIYRQAPWI
EVEAKHKEVA IAHLRSWWLM GQ