ID   UVSSA_CAEBR             Reviewed;         565 AA.
AC   A8XY47;
DT   13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=UV-stimulated scaffold protein A homolog;
GN   Name=uvs-1 {ECO:0000312|WormBase:CBG20579};
GN   ORFNames=CBG20579 {ECO:0000312|WormBase:CBG20579};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Factor involved in transcription-coupled nucleotide excision
CC       repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase
CC       II-blocking lesions to be rapidly removed from the transcribed strand
CC       of active genes. {ECO:0000250|UniProtKB:Q23088,
CC       ECO:0000250|UniProtKB:Q2YD98}.
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q2YD98}.
CC       Note=Accumulates at UV DNA damage sites.
CC       {ECO:0000250|UniProtKB:Q2YD98}.
CC   -!- SIMILARITY: Belongs to the UVSSA family. {ECO:0000305}.
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DR   EMBL; HE601305; CAP37564.1; -; Genomic_DNA.
DR   RefSeq; XP_002635591.1; XM_002635545.1.
DR   AlphaFoldDB; A8XY47; -.
DR   SMR; A8XY47; -.
DR   STRING; 6238.CBG20579; -.
DR   EnsemblMetazoa; CBG20579.1; CBG20579.1; WBGene00039535.
DR   GeneID; 8577586; -.
DR   KEGG; cbr:CBG_20579; -.
DR   CTD; 8577586; -.
DR   WormBase; CBG20579; CBP19902; WBGene00039535; Cbr-uvs-1.
DR   eggNOG; KOG2374; Eukaryota.
DR   HOGENOM; CLU_023577_0_0_1; -.
DR   InParanoid; A8XY47; -.
DR   OMA; KNNADCH; -.
DR   OrthoDB; 996127at2759; -.
DR   Proteomes; UP000008549; Chromosome V.
DR   GO; GO:0005694; C:chromosome; IBA:GO_Central.
DR   GO; GO:0000993; F:RNA polymerase II complex binding; IBA:GO_Central.
DR   GO; GO:0009411; P:response to UV; IBA:GO_Central.
DR   GO; GO:0006283; P:transcription-coupled nucleotide-excision repair; IBA:GO_Central.
DR   InterPro; IPR018610; UVSSA.
DR   PANTHER; PTHR28670; PTHR28670; 1.
DR   Pfam; PF09740; DUF2043; 1.
PE   3: Inferred from homology;
KW   Chromosome; Coiled coil; DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..565
FT                   /note="UV-stimulated scaffold protein A homolog"
FT                   /id="PRO_0000417998"
FT   REGION          11..156
FT                   /note="VHS-like"
FT   REGION          510..530
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          542..565
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          155..215
FT                   /evidence="ECO:0000255"
FT   COILED          480..510
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   565 AA;  65841 MW;  19861ED3F709F201 CRC64;
     MQEDVYRSGI RKNLNRILQE LTDDGKLDFE SVPYQNLKAE IEKRDEECTE VLCKVLLETA
     SRSGCADRQF VLQLFNEYFC NSSLFRDQIL NDPKEFIEIM LETDPIRNPL PGSKSEGNEL
     KSKSLAFIKN WEKMYAKNDA RMKCLAVTLR KTKFVDYENG EKKIEEERKR REFLDERRRM
     IVERTLSLYK SKFEEIKEDV ERLKMELETT MEMLVPSFTN SDDVDIPMDI PSTSSKSFEL
     VIEDLSPLIK VNADNDAIVE AFLGAKTVLI HRVQTMRKLA KGLLPLKGAG ESLAQSIIDY
     RDVIKKLVLK ADEIRIKTKK KPVQKAKKFD DDFIDVEISI DDILMVQYAN EASEDVKEDV
     KEPEKKLANP KKEEPKVKFV SFGLDLKYWG EERKDVEVPK NNADCHRFWR SADESTVAGT
     VHDTVYTQRQ FTFVGEAPKI DRECLAKLPS GALCKRKDMF KCPLHGPLVD RDANGKPVKD
     EDRLKEIDRK ERKRLKEAEE FSRKIVKEYE SKTKRKRKHE EETSVRSRLQ KKLFDPKTIQ
     RVSADITSQQ RSRLEKNFSH QFSHL