ID   UVSSA_CAEEL             Reviewed;         594 AA.
AC   Q23088;
DT   13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=UV-stimulated scaffold protein A homolog;
GN   Name=uvs-1 {ECO:0000303|PubMed:27043179, ECO:0000312|WormBase:ZK742.2};
GN   ORFNames=ZK742.2 {ECO:0000312|WormBase:ZK742.2};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   FUNCTION.
RX   PubMed=27043179; DOI=10.1016/j.dnarep.2016.03.008;
RA   Babu V., Schumacher B.;
RT   "A C. elegans homolog for the UV-hypersensitivity syndrome disease gene
RT   UVSSA.";
RL   DNA Repair 41:8-15(2016).
CC   -!- FUNCTION: Factor involved in transcription-coupled nucleotide excision
CC       repair (TC-NER) in response to UV damage (PubMed:27043179). TC-NER
CC       allows RNA polymerase II-blocking lesions to be rapidly removed from
CC       the transcribed strand of active genes (By similarity).
CC       {ECO:0000250|UniProtKB:Q2YD98, ECO:0000305|PubMed:27043179}.
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q2YD98}.
CC       Note=Accumulates at UV DNA damage sites.
CC       {ECO:0000250|UniProtKB:Q2YD98}.
CC   -!- SIMILARITY: Belongs to the UVSSA family. {ECO:0000305}.
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DR   EMBL; FO080684; CCD65778.1; -; Genomic_DNA.
DR   PIR; F89113; F89113.
DR   RefSeq; NP_505012.2; NM_072611.5.
DR   AlphaFoldDB; Q23088; -.
DR   SMR; Q23088; -.
DR   STRING; 6239.ZK742.2; -.
DR   EPD; Q23088; -.
DR   PaxDb; Q23088; -.
DR   EnsemblMetazoa; ZK742.2.1; ZK742.2.1; WBGene00022812.
DR   GeneID; 179158; -.
DR   KEGG; cel:CELE_ZK742.2; -.
DR   UCSC; ZK742.2; c. elegans.
DR   CTD; 179158; -.
DR   WormBase; ZK742.2; CE51871; WBGene00022812; uvs-1.
DR   eggNOG; KOG2374; Eukaryota.
DR   HOGENOM; CLU_023577_0_0_1; -.
DR   InParanoid; Q23088; -.
DR   OMA; KNNADCH; -.
DR   OrthoDB; 996127at2759; -.
DR   PhylomeDB; Q23088; -.
DR   Reactome; R-CEL-6781823; Formation of TC-NER Pre-Incision Complex.
DR   Reactome; R-CEL-6782135; Dual incision in TC-NER.
DR   Reactome; R-CEL-6782210; Gap-filling DNA repair synthesis and ligation in TC-NER.
DR   PRO; PR:Q23088; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00022812; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005694; C:chromosome; IBA:GO_Central.
DR   GO; GO:0000993; F:RNA polymerase II complex binding; IBA:GO_Central.
DR   GO; GO:0009411; P:response to UV; IMP:UniProtKB.
DR   GO; GO:0006283; P:transcription-coupled nucleotide-excision repair; IMP:UniProtKB.
DR   InterPro; IPR018610; UVSSA.
DR   PANTHER; PTHR28670; PTHR28670; 1.
DR   Pfam; PF09740; DUF2043; 1.
PE   3: Inferred from homology;
KW   Chromosome; Coiled coil; DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..594
FT                   /note="UV-stimulated scaffold protein A homolog"
FT                   /id="PRO_0000417999"
FT   REGION          24..170
FT                   /note="VHS-like"
FT   REGION          533..558
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          170..198
FT                   /evidence="ECO:0000255"
FT   COILED          503..540
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   594 AA;  69037 MW;  42F86B1261B1DDF0 CRC64;
     MLKRRQPKYC SFMDSIDNST TIIRKNLNRF IRELTDDGKL DFESIPYQNL QKEVANQDEE
     GCENVIEVLL DTTSRSGCPD RKLILQLFNS FFLQFPIFRE NLLNDPSEFL ELMFETNPIR
     NPLPGSKKHG NELKVEAITV IKSWEKEKCV KNDARMKCLV VTLKKTKFVD YENGAKKIEA
     ERKRKKILEE RKMKMIENSV NVYSSKYHEI KNDAETLSME LTTTMQMLVP SFTTADPEVP
     STSTSTPSAI SDSKSFEIFI PDLTPEISVS SENDAIVEAF LGAKLSLIHR VQTLRKLVKR
     LQLLKQPGEK LAQEIIDYRD GIKNLVLKAD ELRIINPRPP KNKRKKSDDD FIDVDISIDD
     ILMVQYAEKL EVDVKSKDES EKITESPEKH KIEMKNEKPV KIKTVPFGLD LKYWGEERKD
     VEVPKNNADC HRFWRSADEG TVAGKAQQSI YTQRQYTFIG KAPDNRKVCL AKMKSGKLCP
     RKDYYTCPLH GKIVDRDDEG RPINEEDRLE ENYRKEQNHL KEADKIRQMI EKEYESKTKR
     RKKHDVDTTA SEDVRNRLQK KLLDPKTIQR VSADLDASRK NRLEKNFGQQ FSHF