ID   UVSSA_CHICK             Reviewed;         730 AA.
AC   E1C760;
DT   13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2010, sequence version 1.
DT   03-AUG-2022, entry version 43.
DE   RecName: Full=UV-stimulated scaffold protein A;
GN   Name=UVSSA;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Red jungle fowl;
RX   PubMed=15592404; DOI=10.1038/nature03154;
RA   Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P.,
RA   Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B.,
RA   Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C.,
RA   Fulton R.S., Graves T.A., Kremitzki C., Layman D., Magrini V.,
RA   McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O.,
RA   Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W.,
RA   Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D.,
RA   Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K.,
RA   Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L.,
RA   Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B.,
RA   Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M.,
RA   Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA   Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA   Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA   Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M.,
RA   Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S.,
RA   Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M.,
RA   Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M.,
RA   Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A.,
RA   Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S.,
RA   Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J.,
RA   Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J.,
RA   Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E.,
RA   Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M.,
RA   Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A.,
RA   Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA   Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA   Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E.,
RA   Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S.,
RA   Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E.,
RA   Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R.,
RA   Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R.,
RA   Wilson R.K.;
RT   "Sequence and comparative analysis of the chicken genome provide unique
RT   perspectives on vertebrate evolution.";
RL   Nature 432:695-716(2004).
CC   -!- FUNCTION: Factor involved in transcription-coupled nucleotide excision
CC       repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase
CC       II-blocking lesions to be rapidly removed from the transcribed strand
CC       of active genes (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000250}. Note=Accumulates at UV
CC       DNA damage sites. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UVSSA family. {ECO:0000305}.
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DR   EMBL; AADN02014907; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AADN02014908; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AADN02014909; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AADN02014910; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AADN02014911; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AADN02014912; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AADN02014913; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AADN02014914; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; E1C760; -.
DR   SMR; E1C760; -.
DR   STRING; 9031.ENSGALP00000025298; -.
DR   PaxDb; E1C760; -.
DR   VEuPathDB; HostDB:geneid_422903; -.
DR   eggNOG; KOG2374; Eukaryota.
DR   InParanoid; E1C760; -.
DR   OrthoDB; 996127at2759; -.
DR   PhylomeDB; E1C760; -.
DR   TreeFam; TF321660; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005694; C:chromosome; ISS:UniProtKB.
DR   GO; GO:0000993; F:RNA polymerase II complex binding; ISS:UniProtKB.
DR   GO; GO:0016567; P:protein ubiquitination; ISS:UniProtKB.
DR   GO; GO:0009411; P:response to UV; ISS:UniProtKB.
DR   GO; GO:0006283; P:transcription-coupled nucleotide-excision repair; ISS:UniProtKB.
DR   InterPro; IPR018610; UVSSA.
DR   PANTHER; PTHR28670; PTHR28670; 1.
DR   Pfam; PF09740; DUF2043; 1.
PE   3: Inferred from homology;
KW   Chromosome; Coiled coil; DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..730
FT                   /note="UV-stimulated scaffold protein A"
FT                   /id="PRO_0000417995"
FT   REGION          2..145
FT                   /note="VHS-like"
FT   REGION          213..232
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          399..421
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          485..509
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          656..679
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          155..199
FT                   /evidence="ECO:0000255"
FT   COILED          369..401
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        213..231
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   730 AA;  83841 MW;  0A729955F71E5315 CRC64;
     MDQRLAQLVE ELTTAGEPQL EPGRMKELKK ICRSSEEHLS HAYHLLLTRL HEEHAEMRFS
     AFQIVQELFS RSHLFRTLLV SNFQEFLELT VGTDHEQPLP PPREVAQKLR KAAIAAVQGW
     HEKYGEAYKK LSLGYHYLKQ NKKVDFQDVH ARTVAERKRE EEKQKRLDNV YKEKAKRAEK
     EMAEMSQEVA GTLTEMENCF RLLLPDPFDF TVNSTGLEPN EQTSADEDRS ASSLPTYVGC
     VDDEQPCCSK DILPISQCVR TDQNEELADK QKKPEQDLLD GDTCSEVESG VPVLGDDDYE
     TFVRNHGLIS HKYALDLELS TADIKVHENE DNTAVINSVA DAHKLVRNKF LPSVQSWIQL
     FTRAGINDDR LRCAIDLKNR LEAALRKYKE MNISFKERKR KVMKASDDGD DDDDDEDDFV
     EVPEKEGYEP HIPDHLRKEY GLENCPKKDE SVKKDSCSLT KTKQKNEDEL DPTCAAATLK
     LIRDKLPNES ATTEPAALEE PDSKRRKLEE ERAKAPLMPF GLDLHYWGQD QPSAGKILKF
     TSEHRFWAPS EVEEEVENKE ITEMLKTRYI TFAGKFEPVK HKCRAPMPDG SLCERQDRIK
     CPFHGKIIPR DECGVPINAE DRAREEKMRF EKQATQPETE WRDPEFMREV EAATGVDLGS
     SKTNGKGGKK KGKKKYPNLT DLKQQANTAR SRLEKIVFNK GAVKRVVKAM NQMDQRKHEK
     FANQFNYALN