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UVSSA_MOUSE
ID   UVSSA_MOUSE             Reviewed;         717 AA.
AC   Q9D479; B2RQ84; B7ZN03; Q3U1A8; Q6P7V8; Q6ZPN7;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2012, sequence version 2.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=UV-stimulated scaffold protein A;
GN   Name=Uvssa; Synonyms=Kiaa1530;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, and NOD; TISSUE=Spleen, and Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Limb;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 84-717.
RC   TISSUE=Brain;
RX   PubMed=14621295; DOI=10.1093/dnares/10.4.167;
RA   Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA   Saga Y., Nagase T., Ohara O., Koga H.;
RT   "Prediction of the coding sequences of mouse homologues of KIAA gene: III.
RT   The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT   identified by screening of terminal sequences of cDNA clones randomly
RT   sampled from size-fractionated libraries.";
RL   DNA Res. 10:167-180(2003).
RN   [6]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-403, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Kidney;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Factor involved in transcription-coupled nucleotide excision
CC       repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase
CC       II-blocking lesions to be rapidly removed from the transcribed strand
CC       of active genes. Acts by promoting stabilization of ERCC6 by recruiting
CC       deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced
CC       degradation of ERCC6 by the proteasome. Interacts with the elongating
CC       form of RNA polymerase II (RNA pol IIo) and facilitates its
CC       ubiquitination at UV damage sites, leading to promote RNA pol IIo
CC       backtracking to allow access to the nucleotide excision repair
CC       machinery. Not involved in processing oxidative damage (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the elongating form of RNA polymerase II (RNA
CC       pol IIo). Interacts with ERCC6, ERCC8 and USP7 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000250}. Note=Accumulates at UV
CC       DNA damage sites. {ECO:0000250}.
CC   -!- PTM: Monoubiquitinated: ubiquitination does not increase in response to
CC       UV. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UVSSA family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB30399.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAC98194.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AK016722; BAB30399.1; ALT_INIT; mRNA.
DR   EMBL; AK156117; BAE33591.1; -; mRNA.
DR   EMBL; AC145072; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH466524; EDL37418.1; -; Genomic_DNA.
DR   EMBL; BC061483; AAH61483.1; -; mRNA.
DR   EMBL; BC137803; AAI37804.1; -; mRNA.
DR   EMBL; BC144920; AAI44921.1; -; mRNA.
DR   EMBL; AK129384; BAC98194.1; ALT_INIT; Transcribed_RNA.
DR   CCDS; CCDS39064.1; -.
DR   RefSeq; NP_001074570.1; NM_001081101.2.
DR   RefSeq; XP_006504171.1; XM_006504108.3.
DR   AlphaFoldDB; Q9D479; -.
DR   SMR; Q9D479; -.
DR   BioGRID; 214478; 1.
DR   STRING; 10090.ENSMUSP00000085170; -.
DR   iPTMnet; Q9D479; -.
DR   PhosphoSitePlus; Q9D479; -.
DR   EPD; Q9D479; -.
DR   jPOST; Q9D479; -.
DR   MaxQB; Q9D479; -.
DR   PaxDb; Q9D479; -.
DR   PeptideAtlas; Q9D479; -.
DR   PRIDE; Q9D479; -.
DR   ProteomicsDB; 300099; -.
DR   Antibodypedia; 22237; 52 antibodies from 18 providers.
DR   Ensembl; ENSMUST00000087864; ENSMUSP00000085170; ENSMUSG00000037355.
DR   Ensembl; ENSMUST00000202816; ENSMUSP00000144400; ENSMUSG00000037355.
DR   GeneID; 71101; -.
DR   KEGG; mmu:71101; -.
DR   UCSC; uc008xar.1; mouse.
DR   CTD; 57654; -.
DR   MGI; MGI:1918351; Uvssa.
DR   VEuPathDB; HostDB:ENSMUSG00000037355; -.
DR   eggNOG; KOG2374; Eukaryota.
DR   GeneTree; ENSGT00390000000377; -.
DR   HOGENOM; CLU_023577_0_0_1; -.
DR   InParanoid; Q9D479; -.
DR   OMA; TSEHRFW; -.
DR   OrthoDB; 996127at2759; -.
DR   PhylomeDB; Q9D479; -.
DR   TreeFam; TF321660; -.
DR   Reactome; R-MMU-6781823; Formation of TC-NER Pre-Incision Complex.
DR   Reactome; R-MMU-6782135; Dual incision in TC-NER.
DR   Reactome; R-MMU-6782210; Gap-filling DNA repair synthesis and ligation in TC-NER.
DR   BioGRID-ORCS; 71101; 1 hit in 107 CRISPR screens.
DR   ChiTaRS; Uvssa; mouse.
DR   PRO; PR:Q9D479; -.
DR   Proteomes; UP000000589; Chromosome 5.
DR   RNAct; Q9D479; protein.
DR   Bgee; ENSMUSG00000037355; Expressed in manus and 217 other tissues.
DR   ExpressionAtlas; Q9D479; baseline and differential.
DR   Genevisible; Q9D479; MM.
DR   GO; GO:0005694; C:chromosome; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0000993; F:RNA polymerase II complex binding; ISS:UniProtKB.
DR   GO; GO:0016567; P:protein ubiquitination; ISS:UniProtKB.
DR   GO; GO:0009411; P:response to UV; ISS:UniProtKB.
DR   GO; GO:0006283; P:transcription-coupled nucleotide-excision repair; ISS:UniProtKB.
DR   Gene3D; 1.25.40.90; -; 1.
DR   InterPro; IPR008942; ENTH_VHS.
DR   InterPro; IPR018610; UVSSA.
DR   PANTHER; PTHR28670; PTHR28670; 1.
DR   Pfam; PF09740; DUF2043; 1.
DR   SUPFAM; SSF48464; SSF48464; 1.
PE   1: Evidence at protein level;
KW   Chromosome; Coiled coil; DNA damage; DNA repair; Phosphoprotein;
KW   Reference proteome; Ubl conjugation.
FT   CHAIN           1..717
FT                   /note="UV-stimulated scaffold protein A"
FT                   /id="PRO_0000317283"
FT   REGION          2..145
FT                   /note="VHS-like"
FT   REGION          231..253
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          277..301
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          389..418
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          479..503
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          595..672
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          169..199
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        280..301
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        479..493
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        595..622
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         284
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q2YD98"
FT   MOD_RES         291
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q2YD98"
FT   MOD_RES         403
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   CONFLICT        82
FT                   /note="D -> G (in Ref. 4; AAI44921)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        397..442
FT                   /note="Missing (in Ref. 5; BAC98194)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   717 AA;  81759 MW;  ACC97A8DFAB47BB5 CRC64;
     MDQKLSQLIE ELTTSGESQL NAQKMKELKK ICKSSEEQLS HAYRLLITQL TQGHAEIRLS
     AFQIVDELFT RSHQFRMLLV SDFQEFLELT LGTDSDRPLP PPREAAQRLR QAAMQAVEGW
     NEKFGQAYKK LALGYHFLKH TKKVDFRDIN VRTVAERKRE EEKQKHLDKI HRESADRAKR
     EMEEMYDEIE CCLTEVENCF KLLVPLDFVP CPEDKFFGEA SSMTEGYAPC PLSPDLATPR
     ESGLSGPQDE EQPCCSKDLV ASAYHVGSVV GLKALPQTAM KDSSRDEDEP SDPDDFLRSH
     GLGSHKYTLD VEVPSDGLKV QENEDNLAVL HAARDSLKLI QNKFLPTVCS WVQRFTRAGT
     YSAHLKQAID LKMELELALK KYEELNIEPG RGQRSRTEAL EDSEDEDQDF VEVPEKEGYE
     PRIPDHLRAE YGLEPKAPLK TLEKGTAVCK LQERTRMRRE EEASDPTSAA AQMLRLQDCL
     SSPSPSSTRV LPGPEEAQKQ AERARAPIVP FGVDLCYWGQ EQLTAGKILK SDSQHRFWKP
     SEVEEEVDSA HVSEMLHSRH ITFSGTFEPV QHKCRALRPN GRLCERQDRL KCPFHGKIIP
     RDDKGQPLNP EDRAREQRQQ LQRQQAHPDW QDPEFLKDVE AATGVDLGSS RSSKKGKGKK
     KKHPNLTDLR ERTNTARARL EKKVFAKAAV QRVVAAMNQM DQKKHEKFAN QFNYALK
 
 
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