UVSSA_XENTR
ID UVSSA_XENTR Reviewed; 743 AA.
AC F7AEX0; A9JRL1;
DT 13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 1.
DT 03-AUG-2022, entry version 52.
DE RecName: Full=UV-stimulated scaffold protein A;
GN Name=uvssa;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Factor involved in transcription-coupled nucleotide excision
CC repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase
CC II-blocking lesions to be rapidly removed from the transcribed strand
CC of active genes (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000250}. Note=Accumulates at UV
CC DNA damage sites. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the UVSSA family. {ECO:0000305}.
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DR EMBL; AAMC01122916; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01122917; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC155701; AAI55702.1; -; mRNA.
DR RefSeq; NP_001107306.1; NM_001113834.1.
DR AlphaFoldDB; F7AEX0; -.
DR SMR; F7AEX0; -.
DR STRING; 8364.ENSXETP00000023371; -.
DR PaxDb; F7AEX0; -.
DR GeneID; 100135095; -.
DR KEGG; xtr:100135095; -.
DR CTD; 57654; -.
DR Xenbase; XB-GENE-5833232; uvssa.
DR eggNOG; KOG2374; Eukaryota.
DR HOGENOM; CLU_023577_0_0_1; -.
DR InParanoid; F7AEX0; -.
DR OMA; TSEHRFW; -.
DR OrthoDB; 996127at2759; -.
DR TreeFam; TF321660; -.
DR Reactome; R-XTR-6781823; Formation of TC-NER Pre-Incision Complex.
DR Reactome; R-XTR-6782135; Dual incision in TC-NER.
DR Reactome; R-XTR-6782210; Gap-filling DNA repair synthesis and ligation in TC-NER.
DR Proteomes; UP000008143; Chromosome 1.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000010677; Expressed in 2-cell stage embryo and 12 other tissues.
DR GO; GO:0005694; C:chromosome; ISS:UniProtKB.
DR GO; GO:0000993; F:RNA polymerase II complex binding; ISS:UniProtKB.
DR GO; GO:0016567; P:protein ubiquitination; ISS:UniProtKB.
DR GO; GO:0009411; P:response to UV; ISS:UniProtKB.
DR GO; GO:0006283; P:transcription-coupled nucleotide-excision repair; ISS:UniProtKB.
DR Gene3D; 1.25.40.90; -; 1.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR018610; UVSSA.
DR PANTHER; PTHR28670; PTHR28670; 1.
DR Pfam; PF09740; DUF2043; 1.
PE 2: Evidence at transcript level;
KW Chromosome; Coiled coil; DNA damage; DNA repair; Reference proteome.
FT CHAIN 1..743
FT /note="UV-stimulated scaffold protein A"
FT /id="PRO_0000417997"
FT REGION 2..145
FT /note="VHS-like"
FT REGION 221..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 413..482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 500..525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 147..199
FT /evidence="ECO:0000255"
FT COILED 380..411
FT /evidence="ECO:0000255"
FT COMPBIAS 224..281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..310
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..449
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 211
FT /note="A -> V (in Ref. 2; AAI55702)"
FT /evidence="ECO:0000305"
FT CONFLICT 409
FT /note="K -> R (in Ref. 2; AAI55702)"
FT /evidence="ECO:0000305"
FT CONFLICT 523
FT /note="L -> P (in Ref. 2; AAI55702)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 743 AA; 84679 MW; 29F26FEE2FB8418D CRC64;
MDQKLSELVE VLTTSGEPQL NPEKLKELKK ICRSSDEHIN HVYHLLMTQL NQEHAEIRLS
AFQIVTELFA RSHLFRTLLI SNFQEFLELT VETDHEQPLP PPKEVAQKMK ILAIKTVQEW
HEKFGEAYKK LSLGYHFLKQ NKKIDFQDVR SRTQAERKRE EEKQRRLENI YKEKVKKATA
EMEDMLEEIQ SSLTEMENCF RLLLPDPREF AVFTDEKDFA SDMRTKPTSQ SPSHSKSTSQ
SSAYSKSTSQ VSFDNDDEQP CCSKNLPPFP SSCTSSASGA ERSLGEGAKE SDKSARKSDT
DDSDGDYEGS REAFLRDHGL GSHAYSLSLE ISTDLKVNEN ENNTDVLNNL MDAHKLLKQK
YWPAVQSWIQ LFTKAGTNSE SLKCAIDVKK EIEAALKKYK EMNIDCHTKE RKVMTASDDD
DDDDEFEEVP EKEGYEPHIP DHLREEYGLE PSASKQPGKK TEVKRPNVPQ VPPSQKRIND
ELNPTCAAAT MKTMKDKMAK ALPGSSRNAG EPKSKCPKRE TDLSQAPVAP CGLDLHHWGE
EQPSAGKMLK FSSLHRFWAP NEVDEEVESK ELEALVKTRY VTLPGKFEPV KHKCLAPMPN
GSLCERQDRY KCPFHGKIVP RDAIGVPINA EDRAREAREK FEKQGEEQDW RDPELMREIE
QATGVDLGSS KCPVKGKGKG VKRNLKKKYP NLTDLKQKAN TSRSRLEKKV FNTGSVKRVI
SAMNQADKRR HEKFANQFNY ALN
