ID   CAGA_HELPJ              Reviewed;        1167 AA.
AC   Q9ZLT1;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Cytotoxicity-associated immunodominant antigen;
DE   AltName: Full=120 kDa protein;
DE   AltName: Full=CAG pathogenicity island protein 26;
GN   Name=cagA; Synonyms=cag26, cai; OrderedLocusNames=jhp_0495;
OS   Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J99 / ATCC 700824;
RX   PubMed=9923682; DOI=10.1038/16495;
RA   Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA   Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J.,
RA   Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D.,
RA   Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.;
RT   "Genomic sequence comparison of two unrelated isolates of the human gastric
RT   pathogen Helicobacter pylori.";
RL   Nature 397:176-180(1999).
CC   -!- FUNCTION: May be necessary for the transcription, folding, export, or
CC       function of the cytotoxin.
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DR   EMBL; AE001439; AAD06073.1; -; Genomic_DNA.
DR   PIR; B71924; B71924.
DR   RefSeq; WP_000180410.1; NC_000921.1.
DR   AlphaFoldDB; Q9ZLT1; -.
DR   SMR; Q9ZLT1; -.
DR   IntAct; Q9ZLT1; 1.
DR   STRING; 85963.jhp_0495; -.
DR   EnsemblBacteria; AAD06073; AAD06073; jhp_0495.
DR   KEGG; hpj:jhp_0495; -.
DR   eggNOG; COG1842; Bacteria.
DR   OMA; MGVFDES; -.
DR   Proteomes; UP000000804; Chromosome.
DR   GO; GO:0019534; F:toxin transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR005169; CagA_C.
DR   InterPro; IPR045157; CagA_N.
DR   InterPro; IPR004355; IVSec_CagA.
DR   Pfam; PF03507; CagA; 2.
DR   Pfam; PF18971; CagA_N; 1.
DR   PRINTS; PR01553; TYPE4SSCAGA.
PE   4: Predicted;
FT   CHAIN           1..1167
FT                   /note="Cytotoxicity-associated immunodominant antigen"
FT                   /id="PRO_0000089278"
FT   REGION          632..651
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1167 AA;  129730 MW;  FD5E86B81CEBD0F2 CRC64;
     MTNEAINQQP QTEAAFNPQQ FINNLQVAFI KVDNVVASFD PNQKPIVDKN DRDNRQAFEK
     ISQLREEFAN KAIKNPTKKN QYFSSFISKS NDLIDKDNLI DTGSSIKSFQ KFGTQRYQIF
     MNWVSHQNDP SKINTQKIRG FMENIIQPPI SDDKEKAEFL RSAKQAFAGI IIGNQIRSDQ
     KFMGVFDESL KERQEAEKNG EPNGDPTGGD WLDIFLSFVF NKKQSSDLKE TLNQEPVPHV
     QPDVATTTTD IQSLPPEARD LLDERGNFSK FTLGDMNMLD VEGVADIDPN YKFNQLLIHN
     NALSSVLMGS HNGIEPEKVS LLYGNNGGPE ARHDWNATVG YKNQRGDNVA TLINVHMKNG
     SGLVIAGGEK GINNPSFYLY KEDQLTGSQR ALSQEEIQNK VDFMEFLAQN NAKLDNLSKK
     EKEKFQNEIE DFQKDSKAYL DALGNDHIAF VSKKDKKHLA LVAEFGNGEL SYTLKDYGKK
     ADKALDREAK TTLQGSLKHD GVMFVDYSNF KYTNASKSPD KGVGATNGVS HLEAGFSKVA
     VFNLPNLNNL AITSVVRQDL EDKLIAKGLS PQEANKLVKD FLSSNKELVG KALNFNKAVA
     EAKNTGNYDE VKQAQKDLEK SLKKRERLEK DVAKNLESKS GNKNKMEAKS QANSQKDEIF
     ALINKEANRD ARAIAYAQNL KGIKRELSDK LENINKDLKD FSKSFDEFKN GKNKDFSKAE
     ETLKALKGSV KDLGINPEWI SKVENLNAAL NEFKNGKNKD FSKVTQAKSD LENSIKDVII
     NQKITDKVDN LNQAVSVAKA TGDFSGVEQA LADLKNFSKE QLAQQAQKNE DFNTGKNSAL
     YQSVKNGVNG TLVGNGLSKA EATTLSKNFS DIKKELNAKL GNFNNNNNNG LENSTEPIYT
     QVAKKVKAKI DRLDQIASGL GDVGQAASFL LKRHDKVDDL SKVGLSANHE PIYATIDDLG
     GPFPLKRHDK VDDLSKVGLS REQKLTQKID NLNQAVSEAK ASHFDNLDQM IDKLKDSTKK
     NVVNLYVESA KKVPTSLSAK LDNYATNSHT RINSNVKNGT INEKATGMLT QKNSEWLKLV
     NDKIVAHNVG SAPLSAYDKI GFNQKNMKDY SDSFKFSTRL SNAVKDIKSG FVQFLTNIFS
     MGSYSLMKAS VEHGVKNTNT KGGFQKS