UVSX_BPT4
ID UVSX_BPT4 Reviewed; 391 AA.
AC P04529; Q9MBK8;
DT 13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2001, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Recombination and repair protein;
GN Name=UVSX;
OS Enterobacteria phage T4 (Bacteriophage T4).
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Caudovirales; Myoviridae; Tevenvirinae; Tequatrovirus.
OX NCBI_TaxID=10665;
OH NCBI_TaxID=562; Escherichia coli.
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2932679; DOI=10.1093/nar/13.20.7473;
RA Fujisawa H., Yonesaki T., Minagawa T.;
RT "Sequence of the T4 recombination gene, uvsX, and its comparison with that
RT of the recA gene of Escherichia coli.";
RL Nucleic Acids Res. 13:7473-7481(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12626685; DOI=10.1128/mmbr.67.1.86-156.2003;
RA Miller E.S., Kutter E., Mosig G., Arisaka F., Kunisawa T., Ruger W.;
RT "Bacteriophage T4 genome.";
RL Microbiol. Mol. Biol. Rev. 67:86-156(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 362-391.
RX PubMed=2668290; DOI=10.1016/s0021-9258(18)71698-0;
RA Hinton D.M.;
RT "Altered expression of the bacteriophage T4 gene 41 (primase-helicase) in
RT an Escherichia coli rho mutant.";
RL J. Biol. Chem. 264:14440-14446(1989).
CC -!- FUNCTION: Important in genetic recombination, DNA repair, and
CC replication. Possesses pairing and strand-transfer activity. Interacts
CC with dda and gene 32 proteins.
CC -!- SIMILARITY: Belongs to the RecA family. {ECO:0000305}.
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DR EMBL; X03099; CAB40822.1; -; Genomic_DNA.
DR EMBL; AF158101; AAD42669.2; -; Genomic_DNA.
DR EMBL; J04978; AAA32523.1; -; Genomic_DNA.
DR EMBL; K03113; AAA32552.1; -; Genomic_DNA.
DR PIR; A04307; RRBPT4.
DR RefSeq; NP_049656.2; NC_000866.4.
DR PDB; 3IO5; X-ray; 2.40 A; A/B=30-358.
DR PDBsum; 3IO5; -.
DR SMR; P04529; -.
DR GeneID; 1258704; -.
DR KEGG; vg:1258704; -.
DR EvolutionaryTrace; P04529; -.
DR Proteomes; UP000009087; Genome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR013765; DNA_recomb/repair_RecA.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020588; RecA_ATP-bd.
DR InterPro; IPR020587; RecA_monomer-monomer_interface.
DR PANTHER; PTHR45900; PTHR45900; 1.
DR Pfam; PF00154; RecA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50162; RECA_2; 1.
DR PROSITE; PS50163; RECA_3; 1.
PE 1: Evidence at protein level;
KW 3D-structure; ATP-binding; DNA damage; DNA recombination; DNA repair;
KW DNA replication; Nucleotide-binding; Reference proteome.
FT CHAIN 1..391
FT /note="Recombination and repair protein"
FT /id="PRO_0000122958"
FT REGION 364..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..378
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 60..67
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT CONFLICT 321..324
FT /note="GPLF -> VLI (in Ref. 1; CAB40822/AAA32552)"
FT /evidence="ECO:0000305"
FT HELIX 37..44
FT /evidence="ECO:0007829|PDB:3IO5"
FT STRAND 53..65
FT /evidence="ECO:0007829|PDB:3IO5"
FT HELIX 66..80
FT /evidence="ECO:0007829|PDB:3IO5"
FT STRAND 85..92
FT /evidence="ECO:0007829|PDB:3IO5"
FT HELIX 97..102
FT /evidence="ECO:0007829|PDB:3IO5"
FT HELIX 107..109
FT /evidence="ECO:0007829|PDB:3IO5"
FT STRAND 110..114
FT /evidence="ECO:0007829|PDB:3IO5"
FT HELIX 118..130
FT /evidence="ECO:0007829|PDB:3IO5"
FT STRAND 138..143
FT /evidence="ECO:0007829|PDB:3IO5"
FT HELIX 168..185
FT /evidence="ECO:0007829|PDB:3IO5"
FT STRAND 189..195
FT /evidence="ECO:0007829|PDB:3IO5"
FT HELIX 214..217
FT /evidence="ECO:0007829|PDB:3IO5"
FT STRAND 218..226
FT /evidence="ECO:0007829|PDB:3IO5"
FT STRAND 239..246
FT /evidence="ECO:0007829|PDB:3IO5"
FT STRAND 248..250
FT /evidence="ECO:0007829|PDB:3IO5"
FT STRAND 255..260
FT /evidence="ECO:0007829|PDB:3IO5"
FT TURN 268..271
FT /evidence="ECO:0007829|PDB:3IO5"
FT HELIX 272..278
FT /evidence="ECO:0007829|PDB:3IO5"
FT STRAND 281..283
FT /evidence="ECO:0007829|PDB:3IO5"
FT STRAND 289..295
FT /evidence="ECO:0007829|PDB:3IO5"
FT TURN 297..299
FT /evidence="ECO:0007829|PDB:3IO5"
FT STRAND 302..304
FT /evidence="ECO:0007829|PDB:3IO5"
FT HELIX 311..314
FT /evidence="ECO:0007829|PDB:3IO5"
FT HELIX 317..324
FT /evidence="ECO:0007829|PDB:3IO5"
FT HELIX 327..337
FT /evidence="ECO:0007829|PDB:3IO5"
SQ SEQUENCE 391 AA; 43998 MW; 96A38E586706CB27 CRC64;
MSDLKSRLIK ASTSKLTAEL TASKFFNEKD VVRTKIPMMN IALSGEITGG MQSGLLILAG
PSKSFKSNFG LTMVSSYMRQ YPDAVCLFYD SEFGITPAYL RSMGVDPERV IHTPVQSLEQ
LRIDMVNQLD AIERGEKVVV FIDSLGNLAS KKETEDALNE KVVSDMTRAK TMKSLFRIVT
PYFSTKNIPC IAINHTYETQ EMFSKTVMGG GTGPMYSADT VFIIGKRQIK DGSDLQGYQF
VLNVEKSRTV KEKSKFFIDV KFDGGIDPYS GLLDMALELG FVVKPKNGWY AREFLDEETG
EMIREEKSWR AKDTNCTTFW GPLFKHQPFR DAIKRAYQLG AIDSNEIVEA EVDELINSKV
EKFKSPESKS KSAADLETDL EQLSDMEEFN E
