CAGA_HELPY
ID CAGA_HELPY Reviewed; 1186 AA.
AC P55980;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 25-MAY-2022, entry version 111.
DE RecName: Full=Cytotoxicity-associated immunodominant antigen;
DE AltName: Full=120 kDa protein;
DE AltName: Full=CAG pathogenicity island protein 26;
GN Name=cagA; Synonyms=cag26, cai; OrderedLocusNames=HP_0547;
OS Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85962;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700392 / 26695;
RX PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
CC -!- FUNCTION: May be necessary for the transcription, folding, export, or
CC function of the cytotoxin.
CC -!- INTERACTION:
CC P55980; P94842: ybgC; NbExp=2; IntAct=EBI-528104, EBI-528090;
CC P55980; Q7KZI7: MARK2; Xeno; NbExp=4; IntAct=EBI-528104, EBI-516560;
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DR EMBL; AE000511; AAD07614.1; -; Genomic_DNA.
DR PIR; C64588; C64588.
DR RefSeq; NP_207343.1; NC_000915.1.
DR RefSeq; WP_000180747.1; NC_018939.1.
DR PDB; 3IEC; X-ray; 2.20 A; E/F/G/H=885-1005.
DR PDB; 4DVY; X-ray; 3.30 A; P=1-876.
DR PDB; 4DVZ; X-ray; 3.19 A; A=261-829.
DR PDB; 4G0H; X-ray; 3.60 A; A=1-884.
DR PDB; 4IRV; X-ray; 2.04 A; A/B/C/D=19-235.
DR PDB; 5X7B; X-ray; 2.45 A; L/N=966-978.
DR PDB; 5X94; X-ray; 2.60 A; L/M/N/O=966-976.
DR PDBsum; 3IEC; -.
DR PDBsum; 4DVY; -.
DR PDBsum; 4DVZ; -.
DR PDBsum; 4G0H; -.
DR PDBsum; 4IRV; -.
DR PDBsum; 5X7B; -.
DR PDBsum; 5X94; -.
DR AlphaFoldDB; P55980; -.
DR SMR; P55980; -.
DR DIP; DIP-3093N; -.
DR ELM; P55980; -.
DR IntAct; P55980; 18.
DR MINT; P55980; -.
DR STRING; 85962.C694_02825; -.
DR PaxDb; P55980; -.
DR EnsemblBacteria; AAD07614; AAD07614; HP_0547.
DR KEGG; hpy:HP_0547; -.
DR PATRIC; fig|85962.47.peg.591; -.
DR eggNOG; COG1842; Bacteria.
DR OMA; MGVFDES; -.
DR EvolutionaryTrace; P55980; -.
DR PHI-base; PHI:7711; -.
DR Proteomes; UP000000429; Chromosome.
DR GO; GO:0019534; F:toxin transmembrane transporter activity; IEA:InterPro.
DR DisProt; DP01475; -.
DR InterPro; IPR005169; CagA_C.
DR InterPro; IPR045157; CagA_N.
DR InterPro; IPR004355; IVSec_CagA.
DR Pfam; PF03507; CagA; 2.
DR Pfam; PF18971; CagA_N; 1.
DR PRINTS; PR01553; TYPE4SSCAGA.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome.
FT CHAIN 1..1186
FT /note="Cytotoxicity-associated immunodominant antigen"
FT /id="PRO_0000089279"
FT REGION 630..652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..645
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT HELIX 25..44
FT /evidence="ECO:0007829|PDB:4IRV"
FT HELIX 46..48
FT /evidence="ECO:0007829|PDB:4IRV"
FT HELIX 49..79
FT /evidence="ECO:0007829|PDB:4IRV"
FT HELIX 81..83
FT /evidence="ECO:0007829|PDB:4IRV"
FT HELIX 84..101
FT /evidence="ECO:0007829|PDB:4IRV"
FT HELIX 107..117
FT /evidence="ECO:0007829|PDB:4IRV"
FT HELIX 119..130
FT /evidence="ECO:0007829|PDB:4IRV"
FT HELIX 135..137
FT /evidence="ECO:0007829|PDB:4IRV"
FT HELIX 140..149
FT /evidence="ECO:0007829|PDB:4IRV"
FT STRAND 151..153
FT /evidence="ECO:0007829|PDB:4IRV"
FT HELIX 158..182
FT /evidence="ECO:0007829|PDB:4IRV"
FT HELIX 185..190
FT /evidence="ECO:0007829|PDB:4IRV"
FT HELIX 192..201
FT /evidence="ECO:0007829|PDB:4IRV"
FT HELIX 212..217
FT /evidence="ECO:0007829|PDB:4IRV"
FT STRAND 310..313
FT /evidence="ECO:0007829|PDB:4DVZ"
FT STRAND 320..324
FT /evidence="ECO:0007829|PDB:4DVZ"
FT STRAND 336..343
FT /evidence="ECO:0007829|PDB:4DVZ"
FT STRAND 350..358
FT /evidence="ECO:0007829|PDB:4DVZ"
FT STRAND 363..367
FT /evidence="ECO:0007829|PDB:4DVZ"
FT HELIX 376..379
FT /evidence="ECO:0007829|PDB:4DVZ"
FT STRAND 381..383
FT /evidence="ECO:0007829|PDB:4DVZ"
FT TURN 385..387
FT /evidence="ECO:0007829|PDB:4DVZ"
FT STRAND 390..392
FT /evidence="ECO:0007829|PDB:4DVZ"
FT HELIX 395..410
FT /evidence="ECO:0007829|PDB:4DVZ"
FT TURN 411..413
FT /evidence="ECO:0007829|PDB:4DVZ"
FT HELIX 420..425
FT /evidence="ECO:0007829|PDB:4DVZ"
FT HELIX 427..435
FT /evidence="ECO:0007829|PDB:4DVZ"
FT HELIX 437..446
FT /evidence="ECO:0007829|PDB:4DVZ"
FT STRAND 447..452
FT /evidence="ECO:0007829|PDB:4DVZ"
FT STRAND 459..469
FT /evidence="ECO:0007829|PDB:4DVZ"
FT STRAND 471..477
FT /evidence="ECO:0007829|PDB:4DVZ"
FT STRAND 492..496
FT /evidence="ECO:0007829|PDB:4DVZ"
FT HELIX 498..501
FT /evidence="ECO:0007829|PDB:4DVZ"
FT STRAND 502..508
FT /evidence="ECO:0007829|PDB:4DVZ"
FT STRAND 538..543
FT /evidence="ECO:0007829|PDB:4DVZ"
FT TURN 550..554
FT /evidence="ECO:0007829|PDB:4DVZ"
FT HELIX 556..567
FT /evidence="ECO:0007829|PDB:4DVZ"
FT HELIX 572..606
FT /evidence="ECO:0007829|PDB:4DVZ"
FT HELIX 610..638
FT /evidence="ECO:0007829|PDB:4DVZ"
FT HELIX 651..710
FT /evidence="ECO:0007829|PDB:4DVZ"
FT HELIX 720..734
FT /evidence="ECO:0007829|PDB:4DVZ"
FT HELIX 738..755
FT /evidence="ECO:0007829|PDB:4DVZ"
FT HELIX 763..802
FT /evidence="ECO:0007829|PDB:4DVZ"
FT HELIX 806..826
FT /evidence="ECO:0007829|PDB:4DVZ"
SQ SEQUENCE 1186 AA; 132387 MW; B05C3F2CCC4444F4 CRC64;
MTNETIDQTR TPDQTQSQTA FDPQQFINNL QVAFIKVDNV VASFDPDQKP IVDKNDRDNR
QAFDGISQLR EEYSNKAIKN PTKKNQYFSD FIDKSNDLIN KDNLIDVESS TKSFQKFGDQ
RYQIFTSWVS HQKDPSKINT RSIRNFMENI IQPPIPDDKE KAEFLKSAKQ SFAGIIIGNQ
IRTDQKFMGV FDESLKERQE AEKNGGPTGG DWLDIFLSFI FNKKQSSDVK EAINQEPVPH
VQPDIATTTT DIQGLPPEAR DLLDERGNFS KFTLGDMEML DVEGVADIDP NYKFNQLLIH
NNALSSVLMG SHNGIEPEKV SLLYAGNGGF GDKHDWNATV GYKDQQGNNV ATLINVHMKN
GSGLVIAGGE KGINNPSFYL YKEDQLTGSQ RALSQEEIRN KVDFMEFLAQ NNTKLDNLSE
KEKEKFQNEI EDFQKDSKAY LDALGNDRIA FVSKKDTKHS ALITEFNNGD LSYTLKDYGK
KADKALDREK NVTLQGSLKH DGVMFVDYSN FKYTNASKNP NKGVGATNGV SHLEAGFNKV
AVFNLPDLNN LAITSFVRRN LENKLTAKGL SLQEANKLIK DFLSSNKELA GKALNFNKAV
AEAKSTGNYD EVKKAQKDLE KSLRKREHLE KEVEKKLESK SGNKNKMEAK AQANSQKDEI
FALINKEANR DARAIAYTQN LKGIKRELSD KLEKISKDLK DFSKSFDEFK NGKNKDFSKA
EETLKALKGS VKDLGINPEW ISKVENLNAA LNEFKNGKNK DFSKVTQAKS DLENSVKDVI
INQKVTDKVD NLNQAVSVAK AMGDFSRVEQ VLADLKNFSK EQLAQQAQKN EDFNTGKNSE
LYQSVKNSVN KTLVGNGLSG IEATALAKNF SDIKKELNEK FKNFNNNNNG LKNSTEPIYA
KVNKKKTGQV ASPEEPIYTQ VAKKVNAKID RLNQIASGLG GVGQAAGFPL KRHDKVDDLS
KVGLSASPEP IYATIDDLGG PFPLKRHDKV DDLSKVGRSR NQELAQKIDN LNQAVSEAKA
GFFGNLEQTI DKLKDSTKKN VMNLYVESAK KVPASLSAKL DNYAINSHTR INSNIQNGAI
NEKATGMLTQ KNPEWLKLVN DKIVAHNVGS VSLSEYDKIG FNQKNMKDYS DSFKFSTKLN
NAVKDIKSGF THFLANAFST GYYCLARENA EHGIKNVNTK GGFQKS
