ID   UXAB_ALKHC              Reviewed;         512 AA.
AC   Q9KFI7;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Altronate oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00670};
DE            EC=1.1.1.58 {ECO:0000255|HAMAP-Rule:MF_00670};
DE   AltName: Full=Tagaturonate dehydrogenase {ECO:0000255|HAMAP-Rule:MF_00670};
DE   AltName: Full=Tagaturonate reductase {ECO:0000255|HAMAP-Rule:MF_00670};
GN   Name=uxaB {ECO:0000255|HAMAP-Rule:MF_00670}; OrderedLocusNames=BH0492;
OS   Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344
OS   / JCM 9153 / C-125) (Bacillus halodurans).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX   NCBI_TaxID=272558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX   PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA   Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F.,
RA   Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
RT   "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans
RT   and genomic sequence comparison with Bacillus subtilis.";
RL   Nucleic Acids Res. 28:4317-4331(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-altronate + NAD(+) = H(+) + keto-D-tagaturonate + NADH;
CC         Xref=Rhea:RHEA:17813, ChEBI:CHEBI:15378, ChEBI:CHEBI:17360,
CC         ChEBI:CHEBI:17886, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.58;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00670};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00670}.
CC   -!- SIMILARITY: Belongs to the mannitol dehydrogenase family. UxaB
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00670}.
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DR   EMBL; BA000004; BAB04211.1; -; Genomic_DNA.
DR   PIR; D83711; D83711.
DR   RefSeq; WP_010896670.1; NC_002570.2.
DR   AlphaFoldDB; Q9KFI7; -.
DR   SMR; Q9KFI7; -.
DR   STRING; 272558.10173105; -.
DR   DNASU; 892054; -.
DR   EnsemblBacteria; BAB04211; BAB04211; BAB04211.
DR   KEGG; bha:BH0492; -.
DR   eggNOG; COG0246; Bacteria.
DR   HOGENOM; CLU_027324_1_0_9; -.
DR   OMA; VVIVRPI; -.
DR   OrthoDB; 1442117at2; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000001258; Chromosome.
DR   GO; GO:0009026; F:tagaturonate reductase activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.1040.10; -; 1.
DR   HAMAP; MF_00670; Altron_oxidoreduct; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR023668; Altronate_OxRdtase.
DR   InterPro; IPR013118; Mannitol_DH_C.
DR   InterPro; IPR013131; Mannitol_DH_N.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01232; Mannitol_dh; 1.
DR   Pfam; PF08125; Mannitol_dh_C; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase; Reference proteome.
FT   CHAIN           1..512
FT                   /note="Altronate oxidoreductase"
FT                   /id="PRO_0000170738"
FT   BINDING         26..37
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00670"
SQ   SEQUENCE   512 AA;  58450 MW;  D27D7862C2913A05 CRC64;
     MEKLSHGLVT SRNMIRYKSS QLPERVLQFG EGNFLRGFID WMIQQMNKQN VFNGRVVAIQ
     PTPHGKVVPK LQEQDSLYTV WLRGIADGET VDHHEVITSI SRGLNPYTNW QDVLEVAASP
     DISVVFSNTT EAGLTYLEEG YDKEKAPLSF PGKLAACLWH RYETLGWGEG SGLVIIPCEL
     VEQNGKVLKE LVCRYAKAWN FPQEFFTWLE RENEFCHTLV DRIVPGFPSD TADECFERLG
     YEDILLTVAE PYHLFIIEGS ERVRKLLPFN EAGLHVRWNH LEKHRNMKVR VLNGTHTFMF
     ALSYLSGVDT VGEAMADEQL CSFIRKGLFE EIIPCVDAPE QEVTAFAETV LERFENPFLQ
     HRLTDIGLNA VNKFRTRLMP TFNDYVAQTG EAPTYLLFSL AALINYYRGV EEDGPFLIGR
     RREDSYLIRD DLEVIEAFKV GWQQVNTGKL SLAQLCEDLL SKRELWGVDL SMERKVVDKV
     AESLQIIVEK GMRQAISGVL NQIGGNNHVH KQ