CAGE1_HUMAN
ID CAGE1_HUMAN Reviewed; 777 AA.
AC Q8TC20; D6RCT9; Q5TAM0; Q86TM4; Q8N7R5;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Cancer-associated gene 1 protein;
DE Short=CAGE-1;
DE AltName: Full=Cancer/testis antigen 3;
DE Short=CT3;
GN Name=CAGE1; Synonyms=CTAG3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=12531476; DOI=10.1016/s0167-4781(02)00620-6;
RA Park S., Lim Y., Lee D., Cho B., Bang Y.-J., Sung S., Kim H.-Y., Kim D.-K.,
RA Lee Y.-S., Song Y., Jeoung D.I.;
RT "Identification and characterization of a novel cancer/testis antigen gene
RT CAGE-1.";
RL Biochim. Biophys. Acta 1625:173-182(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
CC -!- INTERACTION:
CC Q8TC20; Q96CS2: HAUS1; NbExp=3; IntAct=EBI-10196469, EBI-2514791;
CC Q8TC20; Q15777: MPPED2; NbExp=3; IntAct=EBI-10196469, EBI-2350461;
CC Q8TC20; Q96HT8: MRFAP1L1; NbExp=3; IntAct=EBI-10196469, EBI-748896;
CC Q8TC20; Q9NUY8: TBC1D23; NbExp=3; IntAct=EBI-10196469, EBI-2853126;
CC Q8TC20; Q9NUY8-2: TBC1D23; NbExp=3; IntAct=EBI-10196469, EBI-10314276;
CC Q8TC20; P09493: TPM1; NbExp=3; IntAct=EBI-10196469, EBI-351158;
CC Q8TC20; Q8N3L3: TXLNB; NbExp=3; IntAct=EBI-10196469, EBI-6116822;
CC Q8TC20-4; Q13515: BFSP2; NbExp=3; IntAct=EBI-11522698, EBI-10229433;
CC Q8TC20-4; Q96RD9: FCRL5; NbExp=3; IntAct=EBI-11522698, EBI-12091825;
CC Q8TC20-4; O60341: KDM1A; NbExp=3; IntAct=EBI-11522698, EBI-710124;
CC Q8TC20-4; Q15777: MPPED2; NbExp=3; IntAct=EBI-11522698, EBI-2350461;
CC Q8TC20-4; O14777: NDC80; NbExp=3; IntAct=EBI-11522698, EBI-715849;
CC Q8TC20-4; Q7Z6G3-2: NECAB2; NbExp=3; IntAct=EBI-11522698, EBI-10172876;
CC Q8TC20-4; P09493-10: TPM1; NbExp=4; IntAct=EBI-11522698, EBI-12123928;
CC Q8TC20-4; Q99816: TSG101; NbExp=3; IntAct=EBI-11522698, EBI-346882;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q8TC20-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8TC20-2; Sequence=VSP_023902;
CC Name=3;
CC IsoId=Q8TC20-3; Sequence=VSP_023969, VSP_023970;
CC Name=4;
CC IsoId=Q8TC20-4; Sequence=VSP_023971;
CC Name=5;
CC IsoId=Q8TC20-5; Sequence=VSP_023969, VSP_047149;
CC -!- TISSUE SPECIFICITY: Testis-specific expression in normal tissues, but
CC wide expression among cancer tissues and cell lines.
CC -!- MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC Haematology;
CC URL="http://atlasgeneticsoncology.org/Genes/CAG1ID475.html";
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DR EMBL; AF414185; AAO47239.1; -; mRNA.
DR EMBL; AK097760; BAC05162.1; -; mRNA.
DR EMBL; AL139095; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC026194; AAH26194.1; -; mRNA.
DR EMBL; BC033545; AAH33545.1; -; mRNA.
DR CCDS; CCDS47367.1; -. [Q8TC20-2]
DR CCDS; CCDS54964.1; -. [Q8TC20-3]
DR CCDS; CCDS54965.1; -. [Q8TC20-5]
DR RefSeq; NP_001164163.1; NM_001170692.1. [Q8TC20-5]
DR RefSeq; NP_001164164.1; NM_001170693.1. [Q8TC20-3]
DR RefSeq; NP_995586.1; NM_205864.2. [Q8TC20-2]
DR AlphaFoldDB; Q8TC20; -.
DR SMR; Q8TC20; -.
DR BioGRID; 130213; 17.
DR IntAct; Q8TC20; 12.
DR STRING; 9606.ENSP00000425493; -.
DR iPTMnet; Q8TC20; -.
DR PhosphoSitePlus; Q8TC20; -.
DR BioMuta; CAGE1; -.
DR DMDM; 134035395; -.
DR EPD; Q8TC20; -.
DR MassIVE; Q8TC20; -.
DR PeptideAtlas; Q8TC20; -.
DR PRIDE; Q8TC20; -.
DR ProteomicsDB; 13991; -.
DR ProteomicsDB; 74073; -. [Q8TC20-1]
DR ProteomicsDB; 74074; -. [Q8TC20-2]
DR ProteomicsDB; 74075; -. [Q8TC20-3]
DR Antibodypedia; 24634; 150 antibodies from 26 providers.
DR DNASU; 285782; -.
DR Ensembl; ENST00000296742.11; ENSP00000296742.7; ENSG00000164304.16. [Q8TC20-2]
DR Ensembl; ENST00000338150.8; ENSP00000338107.4; ENSG00000164304.16. [Q8TC20-3]
DR Ensembl; ENST00000458291.6; ENSP00000390644.2; ENSG00000164304.16. [Q8TC20-4]
DR Ensembl; ENST00000502583.6; ENSP00000425493.1; ENSG00000164304.16. [Q8TC20-5]
DR Ensembl; ENST00000512086.5; ENSP00000427583.1; ENSG00000164304.16. [Q8TC20-1]
DR GeneID; 285782; -.
DR KEGG; hsa:285782; -.
DR MANE-Select; ENST00000502583.6; ENSP00000425493.1; NM_001170692.2; NP_001164163.1. [Q8TC20-5]
DR UCSC; uc063lrc.1; human. [Q8TC20-1]
DR CTD; 285782; -.
DR DisGeNET; 285782; -.
DR GeneCards; CAGE1; -.
DR HGNC; HGNC:21622; CAGE1.
DR HPA; ENSG00000164304; Tissue enriched (testis).
DR MIM; 608304; gene.
DR neXtProt; NX_Q8TC20; -.
DR OpenTargets; ENSG00000164304; -.
DR PharmGKB; PA134933951; -.
DR VEuPathDB; HostDB:ENSG00000164304; -.
DR eggNOG; KOG3650; Eukaryota.
DR GeneTree; ENSGT00390000001805; -.
DR HOGENOM; CLU_020636_0_0_1; -.
DR InParanoid; Q8TC20; -.
DR OMA; SKESHCN; -.
DR OrthoDB; 332349at2759; -.
DR PhylomeDB; Q8TC20; -.
DR TreeFam; TF337775; -.
DR PathwayCommons; Q8TC20; -.
DR SignaLink; Q8TC20; -.
DR BioGRID-ORCS; 285782; 10 hits in 1071 CRISPR screens.
DR ChiTaRS; CAGE1; human.
DR GenomeRNAi; 285782; -.
DR Pharos; Q8TC20; Tbio.
DR PRO; PR:Q8TC20; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q8TC20; protein.
DR Bgee; ENSG00000164304; Expressed in sperm and 49 other tissues.
DR ExpressionAtlas; Q8TC20; baseline and differential.
DR Genevisible; Q8TC20; HS.
DR InterPro; IPR029381; CAGE1.
DR Pfam; PF15066; CAGE1; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..777
FT /note="Cancer-associated gene 1 protein"
FT /id="PRO_0000280750"
FT REGION 737..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 303..560
FT /evidence="ECO:0000255"
FT COMPBIAS 737..756
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..136
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12531476"
FT /id="VSP_023902"
FT VAR_SEQ 668
FT /note="E -> ELLKHKDRITTFRELIAKEKAFQDHAIK (in isoform 3 and
FT isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_023969"
FT VAR_SEQ 669..777
FT /note="VIDCDSDEAKSIRDVPTLLGAKLDKYHSLNEELDFLVTSYEEIIECADQRLA
FT ISHSQIAHLEERNKHLEDLIRKPREKARKPRSKSLENHPKSMTMMPALFKENRNDLD
FT -> LLKHKDRITTFRELIAKEKAFQDHAIKVFQGV (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_023971"
FT VAR_SEQ 704
FT /note="L -> LITKLGHLLESKENHCNRLIEENDKYQRHLGNLIKK (in
FT isoform 5)"
FT /evidence="ECO:0000305"
FT /id="VSP_047149"
FT VAR_SEQ 765..777
FT /note="MPALFKENRNDLD -> LAYNLYIFIGYRLGAVADACNPSTLGGRGGWIT
FT (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_023970"
FT VARIANT 169
FT /note="T -> I (in dbSNP:rs10223538)"
FT /id="VAR_031200"
FT VARIANT 282
FT /note="E -> A (in dbSNP:rs2876098)"
FT /id="VAR_031201"
FT CONFLICT 20
FT /note="V -> A (in Ref. 2; BAC05162)"
FT /evidence="ECO:0000305"
FT CONFLICT 196
FT /note="C -> R (in Ref. 2; BAC05162)"
FT /evidence="ECO:0000305"
FT CONFLICT 596
FT /note="S -> P (in Ref. 2; BAC05162)"
FT /evidence="ECO:0000305"
FT CONFLICT 667
FT /note="K -> E (in Ref. 2; BAC05162)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 777 AA; 90250 MW; F69E220ADD5572EA CRC64;
MNKDYQKFWS SPSDPVHFEV DTSHEKVESM SESDTMNVSN LSQGVMLSHS PICMETTGTT
CDLPQNEIKN FERENEYEST LCEDAYGTLD NLLNDNNIEN YSTNALIQPV DTISISSLRQ
FETVCKFHWV EAFDDEMTEK PEFQSQVYNY AKDNNIKQDS FKEENPMETS VSANTDQLGN
EYFRQPPPRS PPLIHCSGEM LKFTEKSLAK SIAKESALNP SQPPSFLCKT AVPSKEIQNY
GEIPEMSVSY EKEVTAEGVE RPEIVSTWSS AGISWRSEAC RENCEMPDWE QSAESLQPVQ
EDMALNEVLQ KLKHTNRKQE VRIQELQCSN LYLEKRVKEL QMKITKQQVF IDVINKLKEN
VEELIEDKYK IILEKNDTKK TLQNLEEVLA NTQKHLQESR NDKEMLQLQF KKIKANYVCL
QERYMTEMQQ KNKSVSQYLE MDKTLSKKEE EVERLQQLKK ELEKATASAL DLLKREKEAQ
EQEFLSLQEE FQKLEKENLE ERQKLKSRLE KLLTQVRNLQ FMSENERTKN IKLQQQINEV
KNENAKLKQQ VARSEEQNYV PKFETAQLKD QLEEVLKSDI TKDTKTTHSN LLPDCSPCEE
RLNPADIKRA SQLASKMHSL LALMVGLLTC QDIINSDAEH FKESEKVSDI MLQKLKSLHL
KKKTLDKEVI DCDSDEAKSI RDVPTLLGAK LDKYHSLNEE LDFLVTSYEE IIECADQRLA
ISHSQIAHLE ERNKHLEDLI RKPREKARKP RSKSLENHPK SMTMMPALFK ENRNDLD
