ID   UXAB_PECAS              Reviewed;         488 AA.
AC   Q6D9G9;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Altronate oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00670};
DE            EC=1.1.1.58 {ECO:0000255|HAMAP-Rule:MF_00670};
DE   AltName: Full=Tagaturonate dehydrogenase {ECO:0000255|HAMAP-Rule:MF_00670};
DE   AltName: Full=Tagaturonate reductase {ECO:0000255|HAMAP-Rule:MF_00670};
GN   Name=uxaB {ECO:0000255|HAMAP-Rule:MF_00670}; OrderedLocusNames=ECA0646;
OS   Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia
OS   carotovora subsp. atroseptica).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Pectobacteriaceae; Pectobacterium.
OX   NCBI_TaxID=218491;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SCRI 1043 / ATCC BAA-672;
RX   PubMed=15263089; DOI=10.1073/pnas.0402424101;
RA   Bell K.S., Sebaihia M., Pritchard L., Holden M.T.G., Hyman L.J.,
RA   Holeva M.C., Thomson N.R., Bentley S.D., Churcher L.J.C., Mungall K.,
RA   Atkin R., Bason N., Brooks K., Chillingworth T., Clark K., Doggett J.,
RA   Fraser A., Hance Z., Hauser H., Jagels K., Moule S., Norbertczak H.,
RA   Ormond D., Price C., Quail M.A., Sanders M., Walker D., Whitehead S.,
RA   Salmond G.P.C., Birch P.R.J., Parkhill J., Toth I.K.;
RT   "Genome sequence of the enterobacterial phytopathogen Erwinia carotovora
RT   subsp. atroseptica and characterization of virulence factors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:11105-11110(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-altronate + NAD(+) = H(+) + keto-D-tagaturonate + NADH;
CC         Xref=Rhea:RHEA:17813, ChEBI:CHEBI:15378, ChEBI:CHEBI:17360,
CC         ChEBI:CHEBI:17886, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.58;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00670};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00670}.
CC   -!- SIMILARITY: Belongs to the mannitol dehydrogenase family. UxaB
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00670}.
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DR   EMBL; BX950851; CAG73561.1; -; Genomic_DNA.
DR   RefSeq; WP_011092263.1; NC_004547.2.
DR   AlphaFoldDB; Q6D9G9; -.
DR   SMR; Q6D9G9; -.
DR   STRING; 218491.ECA0646; -.
DR   EnsemblBacteria; CAG73561; CAG73561; ECA0646.
DR   KEGG; eca:ECA0646; -.
DR   PATRIC; fig|218491.5.peg.641; -.
DR   eggNOG; COG0246; Bacteria.
DR   HOGENOM; CLU_027324_1_0_6; -.
DR   OMA; VVIVRPI; -.
DR   OrthoDB; 1442117at2; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000007966; Chromosome.
DR   GO; GO:0009026; F:tagaturonate reductase activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.1040.10; -; 1.
DR   HAMAP; MF_00670; Altron_oxidoreduct; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR023668; Altronate_OxRdtase.
DR   InterPro; IPR013118; Mannitol_DH_C.
DR   InterPro; IPR013131; Mannitol_DH_N.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01232; Mannitol_dh; 1.
DR   Pfam; PF08125; Mannitol_dh_C; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase; Reference proteome.
FT   CHAIN           1..488
FT                   /note="Altronate oxidoreductase"
FT                   /id="PRO_0000170744"
FT   BINDING         18..29
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00670"
SQ   SEQUENCE   488 AA;  55557 MW;  14C477128322D778 CRC64;
     MQTLNRRNFP GRQHPDRVIQ FGEGNFLRAF VDWQLDLLNE HTDLDAGIVI VRPIDSDFPP
     ALDTQDGLYT TIIRGLNEQG EAVREPRLIR SVNREINVYR QFDEYLALAH DPNIRFVFSN
     TTEAGISYHA DDRLSDAPPV SFPAKLTRLL YERFCHFDGA ADKGWVLLPC ELIDYNGVAL
     KELVLRYAAQ WELTSTFTAW LNDHNTFCST LVDRIVTGYP RAEVEALQQE MGYQDTFWDT
     AEHFYLFVIQ GPLWLAEELR LNKLDLNVRI VDDIKPYKER KVAILNGAHT ALVPVAFLAG
     LDTVGESMND ALIGKFVEKT IAEEIVPVLD LPHDELTSFA QAVLSRFRNP FIQHQLLSIS
     LNGMTKFRTR ILPQLLTYRE RHGELPARLT FALAALIAFY RGERSGEGDA LQAYPLQDDA
     HWLERYSTLW AGVKENTVSL AELVNVVLRD ADHWEQDLTQ VPGLAAQVTE QLQTIVERGM
     RAAVEGYC